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    CHIMERIC NEWCASTLE DISEASE VIRUS VLPS
    2.
    发明申请
    CHIMERIC NEWCASTLE DISEASE VIRUS VLPS 审中-公开
    CHIMERIC NEWCASTLE病毒病毒VLPS

    公开(公告)号：WO2008103819A3

    公开(公告)日：2008-12-04

    申请号：PCT/US2008054570

    申请日：2008-02-21

    申请人： NOVAVAX INC ,  MAHMOOD KUTUB ,  SMITH GALE ,  PUSHKO PETER

    发明人： MAHMOOD KUTUB ,  SMITH GALE ,  PUSHKO PETER

    IPC分类号： C12N15/63 ,  A61K35/00 ,  C12P19/34

    CPC分类号： C12N7/00 ,  A61K2039/5258 ,  C07K14/005 ,  C12N2710/14143 ,  C12N2760/18122 ,  C12N2760/18123

    摘要： The present invention discloses and claims chimeric virus like particles (VLPs) that express and/or contains Newcastle disease matrix protein. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising chimeric VLPs of the inventions. The invention also includes methods of making and administrating chimeric VLPs to vertebrates, including methods of inducing immunity to infections.

    摘要翻译： 本发明公开并要求表达和/或含有新城疫基质蛋白的嵌合病毒样颗粒（VLP）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，包含本发明的嵌合VLP的制剂和疫苗。 本发明还包括制备和给予脊椎动物嵌合VLP的方法，包括诱导感染免疫的方法。

    FUNCTIONAL INFLUENZA VIRUS LIKE PARTICLES (VLPS)
    4.
    发明申请
    FUNCTIONAL INFLUENZA VIRUS LIKE PARTICLES (VLPS) 审中-公开
    功能性流感病毒样颗粒（VLPS）

    公开(公告)号：WO2007047831A3

    公开(公告)日：2007-07-19

    申请号：PCT/US2006040862

    申请日：2006-10-18

    申请人： NOVAVAX INC ,  SMITH GALE ,  BRIGHT RICK ,  PUSHKO PETER ,  ZHANG JINYOU ,  MAHMOOD KUTUB

    发明人： SMITH GALE ,  BRIGHT RICK ,  PUSHKO PETER ,  ZHANG JINYOU ,  MAHMOOD KUTUB

    IPC分类号： A61K39/00

    CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/55505 ,  A61K2039/55555 ,  C12N7/00 ,  C12N2760/16123 ,  C12N2760/16134

    摘要： The present invention discloses and claims virus like particles (VLPs) that express and/or contains seasonal influenza virus proteins, avian influenza virus proteins and/or influenza virus proteins from viruses with pandemic potential. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising VLPs of the inventions. The invention also includes methods of making and administrating VLPs to vertebrates, including methods of inducing substantial immunity to either seasonal and avian influenza, or at least one symptom thereof.

    摘要翻译： 本发明公开并要求从具有大流行潜力的病毒中表达和/或含有季节性流感病毒蛋白，禽流感病毒蛋白和/或流感病毒蛋白质的病毒样颗粒（VLP）。 本发明包括包含所述蛋白质的载体构建体，包含所述构建体的细胞，制剂和包含本发明的VLP的疫苗。 本发明还包括制备和施用VLP到脊椎动物的方法，包括诱导季节性和禽流感的实质性免疫或其至少一种症状的方法。

    NOVEL VLPS DERIVED FROM CELLS THAT DO NOT EXPRESS A VIRAL MATRIX OR CORE PROTEIN
    7.
    发明申请
    NOVEL VLPS DERIVED FROM CELLS THAT DO NOT EXPRESS A VIRAL MATRIX OR CORE PROTEIN 审中-公开
    从不能表达病毒基质或核心蛋白质的细胞衍生的新型VLPS

    公开(公告)号：WO2008148104A1

    公开(公告)日：2008-12-04

    申请号：PCT/US2008064911

    申请日：2008-05-27

    申请人： NOVAVAX INC ,  SMITH GALE ,  PUSHKO PETER ,  MAHMOOD KUTUB ,  ZHAO BIN

    发明人： SMITH GALE ,  PUSHKO PETER ,  MAHMOOD KUTUB ,  ZHAO BIN

    IPC分类号： C12P21/06

    CPC分类号： A61K39/145 ,  A61K2039/5258 ,  C07K2319/00 ,  C12N7/00 ,  C12N2710/16723 ,  C12N2760/16123

    摘要： The present invention discloses novel influenza virus-like particles (VLPs) that contain chimeric proteins or influenza membrane proteins. The chimeric proteins are derived from fragments of influenza membrane proteins fused to heterologous proteins. The invention includes antigenic formulations and vaccines comprising VLPs of the invention as well as methods of making and administering VLPs to vertebrates, including methods of inducing immunity to infections, such as influenza.

    摘要翻译： 本发明公开了含有嵌合蛋白或流感病毒膜蛋白的新型流感病毒样颗粒（VLPs）。 嵌合蛋白质衍生自与异源蛋白质融合的流感病毒膜蛋白片段。 本发明包括抗原制剂和包含本发明的VLP的疫苗以及向脊椎动物制备和施用VLP的方法，包括诱导感染免疫的方法，例如流感。

    RECOMBINANT E-SELECTIN MADE IN INSECT CELLS
    8.
    发明申请
    RECOMBINANT E-SELECTIN MADE IN INSECT CELLS 审中-公开
    重组电选择素在细胞中的表达

    公开(公告)号：WO2006099006A3

    公开(公告)日：2007-02-01

    申请号：PCT/US2006008340

    申请日：2006-03-08

    申请人： NOVAVAX INC ,  SMITH GALE ,  PUSHKO PETER ,  COICE VITTORIA

    发明人： SMITH GALE ,  PUSHKO PETER ,  COICE VITTORIA

    IPC分类号： C07K14/78 ,  A61K38/39

    CPC分类号： C07K14/70564 ,  A61K38/00

    摘要： The inventive features include recombinant mammalian E-selectin peptides, nucleic acids encoding said peptides, vectors and cells having these nucleic acids, and methods of making the peptides. Further inventive features include methods of treating diseases and conditions associated with inflammation using recombinant mammalian E-selectin peptides to induce mucosal tolerance to E-selectin.

    摘要翻译： 本发明的特征包括重组哺乳动物E-选择素肽，编码所述肽的核酸，具有这些核酸的载体和细胞，以及制备肽的方法。 其它发明特征包括使用重组哺乳动物E-选择蛋白肽治疗与炎症相关的疾病和病症以诱导对E-选择素的粘膜耐受的方法。