公开(公告)号：WO2007097923A2

公开(公告)日：2007-08-30

申请号：PCT/US2007003393

申请日：2007-02-07

Applicant: PHYLOGICA LTD ,  WATT PAUL MICHAEL ,  DUNBRACK ROLAND

Inventor： WATT PAUL MICHAEL ,  DUNBRACK ROLAND

IPC: C40B40/10

CPC classification number: C07K1/047 ,  C07K1/00 ,  C07K7/08 ,  C07K14/001 ,  C12N15/1037 ,  C12N15/1072 ,  C12N15/1089 ,  C12Q1/18 ,  C40B30/02 ,  C40B40/10 ,  G01N33/6824 ,  G01N33/6845 ,  G01N2500/10 ,  G06F19/18 ,  G06F19/22

Abstract: The present invention provides the means for producing libraries of peptide structures for drug screening applications that are capable of folding or assuming their native conformations independently of artificial scaffolds or flanking sequences in the proteins from which they are derived. The libraries can be highly diverse such that they are representative of the repertoire of protein structures existing in nature. The libraries can also be non-redundant or normalized such that the bias towards specific structures existing in source data sets and/or in nature is/are removed. In a particularly preferred embodiment, the present invention provides 30,000 independent fold structures produced by this method. The present invention also provides computer -readable media and systems comprising structural data in relation to the peptide libraries, and methods for displaying and screening the libraries.

Abstract translation: 本发明提供用于生产用于药物筛选应用的肽结构库的方法，其能够独立于衍生自其的蛋白质中的人造支架或侧翼序列折叠或假定其天然构象。 图书馆可以是高度多样化的，因为它们代表了自然界中存在的蛋白质结构的所有组成部分。 这些库也可以是非冗余的或归一化的，使得存在于源数据集中和/或本质上的特定结构的偏移被删除。 在特别优选的实施方案中，本发明提供了通过该方法制备的30,000个独立折叠结构。 本发明还提供了包括与肽库相关的结构数据的计算机可读介质和系统，以及用于显示和筛选文库的方法。