中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

7 records (took 0.018 seconds)

    COLLECTIONS OF BINDING PROTEINS AND TAGS AND USES THEREOF FOR NESTED SORTING AND HIGH THROUGHPUT SCREENING
    2.
    发明申请
    COLLECTIONS OF BINDING PROTEINS AND TAGS AND USES THEREOF FOR NESTED SORTING AND HIGH THROUGHPUT SCREENING 审中-公开
    用于巢式分选和高通量筛选的结合蛋白和标签及其用途的集合

    公开(公告)号：WO0206834A9

    公开(公告)日：2002-07-18

    申请号：PCT/US0122821

    申请日：2001-07-18

    Applicant: POINTILLISTE INC ,  AULT-RICHE DANA ,  KASSNER PAUL D

    Inventor： AULT-RICHE DANA ,  KASSNER PAUL D

    IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  C40B30/04 ,  G01N33/68 ,  G01N37/00

    CPC classification number: C40B30/04 ,  G01N33/6845

    Abstract: Provided herein are addressable collections of anti-tag capture agents, such as antibodies, that are used as tools for sorting proteins containg polypeptide tags for which the capture agents are specific . Also provided are methods of nested sorting using the collections. The methods includes the steps of creating tagged collections of molecules by introducing a set of nucleic acid molecules that encode unique preselected polypeptides to create a library of tagged molecules; either before or after introducing the tags, dividing the library into N divisions; translating each division and reacting each with one of N capture agent collections, identifying the capture agents bound to the polypetide tags linked to molecules on interest, and thereby identifying the one of the divided collections that contains the molecules of interest. The method can further include adding a new set of tags and repeating the sorting process with the same or a different collection capture agents and thereby identifying a protein or molecule of interest.

    Abstract translation: 本文提供了可标记的抗标签捕获剂例如抗体的集合，其被用作用于分选含有捕获剂特异性的多肽标签的蛋白质的工具。 还提供了使用集合进行嵌套排序的方法。 该方法包括以下步骤：通过引入一组编码独特预选多肽的核酸分子来创建标记分子库; 在引入标签之前或之后，将库分成N个部分; 翻译每个分区并且使每个分区与N个捕获剂集合中的一个反应，识别结合到与感兴趣的分子连接的多肽标签的捕获剂，并且由此识别包含感兴趣的分子的分开的集合中的一个。 该方法可以进一步包括添加一组新的标签，并用相同或不同的收集捕获剂重复分类过程，从而鉴定感兴趣的蛋白质或分子。

    NESTED SORTING AND HIGH THROUGHPUT SCREENING
    5.
    发明申请
    NESTED SORTING AND HIGH THROUGHPUT SCREENING 审中-公开
    嵌套分选和高通量筛选

    公开(公告)号：WO0206834A3

    公开(公告)日：2002-10-10

    申请号：PCT/US0122821

    申请日：2001-07-18

    Applicant: POINTILLISTE INC ,  AULT-RICHE DANA ,  KASSNER PAUL D

    Inventor： AULT-RICHE DANA ,  KASSNER PAUL D

    IPC: G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  C40B30/04 ,  G01N33/68 ,  G01N37/00 ,  C07H21/00 ,  G01N33/543

    CPC classification number: C40B30/04 ,  G01N33/6845

    Abstract: Provided herein are addressable collections of anti-tag capture agents, such as antibodies, that are used as tools for sorting proteins containg polypeptide tags for which the capture agents are specific . Also provided are methods of nested sorting using the collections. The methods includes the steps of creating tagged collections of molecules by introducing a set of nucleic acid molecules that encode unique preselected polypeptides to create a library of tagged molecules; either before or after introducing the tags, dividing the library into N divisions; translating each division and reacting each with one of N capture agent collections, identifying the capture agents bound to the polypetide tags linked to molecules on interest, and thereby identifying the one of the divided collections that contains the molecules of interest. The method can further include adding a new set of tags and repeating the sorting process with the same or a different collection capture agents and thereby identifying a protein or molecule of interest.

    Abstract translation: 本文提供了抗标签捕获剂（例如抗体）的可寻址的集合，其被用作用于分选含有捕获剂特异性的多肽标签的蛋白质的工具。 还提供了使用集合进行嵌套排序的方法。 所述方法包括通过引入编码独特预选多肽的一组核酸分子来产生标记分子文库来产生标记的分子集合的步骤; 在引入标签之前或之后，将图书馆分为N个部门; 翻译每个分区并使其与N个捕获剂收集物中的一个反应，鉴定与感兴趣的分子连接的多肽标签结合的捕获剂，从而鉴定包含感兴趣的分子的分割的收集物之一。 该方法可以进一步包括添加一组新标签并用相同或不同的收集捕获剂重复分选过程，从而鉴定感兴趣的蛋白质或分子。

    SELF-ASSEMBLING ARRAYS AND USES THEREOF
    6.
    发明申请
    SELF-ASSEMBLING ARRAYS AND USES THEREOF 审中-公开
    自组装阵列及其用途

    公开(公告)号：WO2004071641A3

    公开(公告)日：2005-02-24

    申请号：PCT/US0334747

    申请日：2003-10-30

    Applicant: POINTILLISTE INC ,  AULT-RICHE DANA ,  KUMBLE KRISHNANAND D ,  SCHULZ RAINER ,  SCHULZ KENNETH

    Inventor： AULT-RICHE DANA ,  KUMBLE KRISHNANAND D ,  SCHULZ RAINER ,  SCHULZ KENNETH

    IPC: B01J20060101 ,  G01N33/53 ,  G01N33/543

    CPC classification number: G01N33/54353

    Abstract: Provided herein are methods, combinations, kits and systems for self-assembly of a self-assembling array to produce self-assembled arrays. The self-assembling arrays contain addressed collections of capture agents and are used with binding partners and reagents for conjugation of binding partners or molecules and/or biological particles for display in self-assembled arrays. The capture agents at each locus in a self-assembling array are specific to one of a set of binding partner molecules. The binding partners are conjugated to molecules and/or biological particles for display. Following conjugation, the resulting conjugates are sorted on the array based on the specific interaction of the binding partner and the capture agent to produce a self-assembled array.

    Abstract translation: 本文提供了用于自组装阵列自组装以产生自组装阵列的方法，组合，套件和系统。 自组装阵列包含寻址的捕获剂的集合，并且与结合配偶体和试剂一起使用，用于结合配偶体或分子和/或生物颗粒的缀合以在自组装阵列中显示。 自组装阵列中每个位点的捕获剂对一组结合配偶体分子之一是特异性的。 结合配偶体与分子和/或生物颗粒缀合以进行显示。 在共轭之后，基于结合配偶体和捕获剂的特异性相互作用，将所得到的缀合物在阵列上进行分选以产生自组装阵列。

    GB1 PEPTIDIC LIBRARIES AND COMPOUNDS, AND METHODS OF SCREENING THE SAME
    7.
    发明申请
    GB1 PEPTIDIC LIBRARIES AND COMPOUNDS, AND METHODS OF SCREENING THE SAME 审中-公开
    GB1PEPTIDIC LIBRARIES AND COMPOUNDS，及其筛选方法

    公开(公告)号：WO2012078313A3

    公开(公告)日：2012-08-23

    申请号：PCT/US2011060276

    申请日：2011-11-10

    Applicant: REFLEXION PHARMACEUTICALS INC ,  UNIV TORONTO ,  SIDHU SACHDEV S ,  UPPALAPATI MARUTI ,  AULT-RICHE DANA

    Inventor： SIDHU SACHDEV S ,  UPPALAPATI MARUTI ,  AULT-RICHE DANA

    IPC: C07K14/71 ,  C07K14/435 ,  C40B40/10 ,  G01N33/68

    CPC classification number: G01N33/6845 ,  C07K1/00 ,  C07K14/315 ,  C40B30/04

    Abstract: GB 1 peptidic libraries and methods of screening the same for specific binding to a target protein are provided. Aspects of the methods include screening GB 1 peptidic libraries for specific binding to 40 residue or more D-target proteins. Once a L-peptidic compound has been identified that specifically binds to the D-target protein, the D-enantiomer of that compound may be produced. GB 1 peptidic compounds that specifically bind to a target molecule are also provided. These libraries, compounds and methods find use in a variety of applications in which specific binding to target molecules, e.g., target proteins is desired.

    Abstract translation: 提供GB 1肽图书馆和筛选相同的特异性结合靶蛋白的方法。 方法的方面包括筛选GB 1肽文库以特异性结合40个残基或更多个D靶蛋白。 一旦确定了特异性结合D靶蛋白的L-肽化合物，就可以生产该化合物的D-对映异构体。 还提供了特异性结合靶分子的GB 1肽化合物。 这些文库，化合物和方法可用于其中期望与靶分子（例如靶蛋白）的特异性结合的多种应用。

Patent Agency Ranking