公开(公告)号：WO2015095604A2

公开(公告)日：2015-06-25

申请号：PCT/US2014/071293

申请日：2014-12-18

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  WATTERS, Alexander ,  INGBER, Donald ,  CARTWRIGHT, Mark ,  SUPER, Michael ,  ROTTMAN, Martin

Inventor： WATTERS, Alexander ,  INGBER, Donald ,  CARTWRIGHT, Mark ,  SUPER, Michael ,  ROTTMAN, Martin ,  MURRAY, Evangelina

IPC: A61K39/395 ,  A61K47/48

CPC classification number: C07K14/4737 ,  A61K38/00 ,  A61K47/42 ,  C07K14/4726 ,  C07K2319/30 ,  C07K2319/33 ,  G01N33/569 ,  G01N33/56911 ,  G01N33/56916 ,  G01N33/56938 ,  G01N33/56944 ,  G01N2333/4737

Abstract: Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.

Abstract translation: 本文描述了工程改造的微生物靶向分子，微生物靶向制品，包含其的试剂盒及其用途。 这样的微生物靶向分子，微生物靶向制品或包含它们的试剂盒可以结合或捕获其微生物或微生物，并因此可以用于各种应用，例如诊断或治疗由微生物 一个主题或任何环境表面。

公开(公告)号：WO2013130875A1

公开(公告)日：2013-09-06

申请号：PCT/US2013/028409

申请日：2013-02-28

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： SUPER, Michael ,  INGBER, Donald E. ,  CARTWRIGHT, Mark J. ,  WATTERS, Alexander ,  WORKMAN, Sam ,  LEVNER, Daniel ,  ROTTMAN, Martin

IPC: C12Q1/18 ,  C12Q1/04 ,  C12Q1/02

CPC classification number: G01N33/56938 ,  C12Q1/18 ,  G01N33/56911 ,  G01N33/56916 ,  G01N2333/245 ,  G01N2333/31 ,  G01N2500/10

Abstract: Embodiments of various aspects described herein are directed to methods, compositions, kits and systems for rapid determination of antibiotic susceptibility of a microbe within hours after a sample is collected. In some embodiments, the methods, compositions, kits and systems described herein can allow determination of antibiotic susceptibility of a microbe based on a small number of microbes, e.g., as few as 5-10 microbes bound to a microbe-targeting substrate described herein.

Abstract translation: 本文描述的各个方面的实施方案涉及用于在收集样品后几小时内快速测定微生物的抗生素敏感性的方法，组合物，试剂盒和系统。 在一些实施方案中，本文所述的方法，组合物，试剂盒和系统可以允许基于少量微生物测定微生物的抗生素敏感性，例如与本文所述的微生物靶向底物结合的少至5-10微克。

公开(公告)号：WO2015009734A3

公开(公告)日：2015-01-22

申请号：PCT/US2014/046716

申请日：2014-07-15

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： CARTWRIGHT, Mark J. ,  GAMINI, Nazita ,  INGBER, Donald E. ,  ROTTMAN, Martin ,  SUPER, Michael ,  TOMOLONIS, Julie A. ,  SINCLAIR, Karen A.

IPC: C12Q1/18 ,  C12Q1/02

Abstract: The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.