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    DEVICES FOR SIMULATING A FUNCTION OF A TISSUE AND METHODS OF USE AND MANUFACTURING THEREOF
    3.
    发明申请
    DEVICES FOR SIMULATING A FUNCTION OF A TISSUE AND METHODS OF USE AND MANUFACTURING THEREOF 审中-公开
    用于模拟组织功能的装置及其使用和制造方法

    公开(公告)号：WO2017003546A2

    公开(公告)日：2017-01-05

    申请号：PCT/US2016/029164

    申请日：2016-04-25

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE

    Inventor： INGBER, Donald E. ,  VAN DER MEER, Andries ,  HERLAND, Anna

    IPC: C12M1/02

    CPC classification number: C12M23/16 ,  C12M25/14 ,  C12M29/10 ,  C12M35/08 ,  C12M41/46

    Abstract: Systems and methods for producing and using a body having a first structure defining a first chamber, a second structure defining a second chamber, a membrane located at an interface region between the first chamber and the second chamber to separate the first chamber from the second chamber. The first chamber comprises a first permeable matrix disposed therein and the first permeable matrix comprises at least one or a plurality of lumens each extending therethrough, which is optionally lined with at least one layer of cells. The second chamber can comprise cells cultured therein. The systems and methods described herein can be used for various applications, including, e.g., growth and/or differentiation of primary cells, and/or simulation of a microenvironment in living tissues and/or organs (to model physiology or disease states, and/or to identify therapeutic agents). The systems and methods can also permit co-cultures of two or more different cell types.

    Abstract translation: 用于制造和使用具有限定第一室的第一结构的物体的系统和方法，限定第二室的第二结构，位于第一室和第二室之间的界面区域处的膜，以将第一室与第二室分离 。 第一室包括设置在其中的第一渗透性基质，第一渗透性基质包括至少一个或多个各自延伸穿过其中的腔，其任选内衬至少一层细胞。 第二室可以包含在其中培养的细胞。 本文描述的系统和方法可用于各种应用，包括例如原代细胞的生长和/或分化，和/或模拟生物组织和/或器官中的微环境（以模拟生理学或疾病状态和/ 或鉴定治疗剂）。 系统和方法还可以允许两种或多种不同细胞类型的共培养。

    ENGINEERED OPSONIN FOR PATHOGEN DETECTION AND TREATMENT
    7.
    发明申请
    ENGINEERED OPSONIN FOR PATHOGEN DETECTION AND TREATMENT 审中-公开
    用于病原体检测和治疗的工程OPSONIN

    公开(公告)号：WO2011090954A2

    公开(公告)日：2011-07-28

    申请号：PCT/US2011/021603

    申请日：2011-01-19

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  SUPER, Michael ,  WAY, Jeffrey, Charles ,  INGBER, Donald E.

    Inventor： SUPER, Michael ,  WAY, Jeffrey, Charles ,  INGBER, Donald E.

    IPC: C07K19/00

    CPC classification number: C07K14/4726 ,  C07K16/44 ,  C07K17/00 ,  C07K2317/53 ,  C07K2317/66 ,  C07K2319/30 ,  G01N33/56961 ,  G01N2333/40

    Abstract: The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases, blood-borne infections or sepsis. An aspect of the invention provides for mannose-binding lectin (MBL), which is an abundant natural serum protein that is part of the innate immune system. The ability of this protein lectin to bind to surface molecules on virtually all classes of biopathogens (viruses, bacteria, fungi, protozoans) make engineered forms of MBL extremely useful in diagnosing and treating infectious diseases and sepsis.

    Abstract translation: 本发明提供了可用于结合生物病原体或鉴定用于治疗和诊断感染性疾病，血源性感染或败血症患者的装置和系统的亚类或特定病原体物种的工程化分子调理素。 本发明的一个方面提供了甘露糖结合凝集素（MBL），其是作为先天免疫系统的一部分的丰富的天然血清蛋白。 这种蛋白凝集素在几乎所有类型的生物病原体（病毒，细菌，真菌，原生动物）上结合表面分子的能力使MBL的工程化形式在诊断和治疗感染性疾病和败血症方面非常有用。

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