公开(公告)号：WO0226267A3

公开(公告)日：2003-04-03

申请号：PCT/US0129256

申请日：2001-09-19

Applicant: PROCTER & GAMBLE

Inventor： PERKINS CHRISTOPHER MARK ,  KITKO DAVID JONATHAN

IPC: G01R33/28 ,  A61B5/055 ,  A61K49/00 ,  A61K49/10 ,  C07D487/08

CPC classification number: A61K49/085 ,  A61K49/10 ,  A61K49/106

Abstract: The present invention relates to pharmaceutical compositions and methods for using said compositions which comprise: a) an effective amount of a magnetic resonance imaging agent, for example, a complex having the formula: b) the balance carriers and other adjunct ingredients. It has been surprisingly discovered that by increasing the lipophilicity of MRI imaging agents, the ability to target different types of body tissue is greatly enhanced. The complexes of the present invention provide enhanced imaging. of arteries and veins, as well as nephric tissue imaging.

Abstract translation: 本发明涉及用于使用所述组合物的药物组合物和方法，所述组合物包含：a）有效量的磁共振成像剂，例如具有下式的复合物：b）余量载体和其它助剂成分。 已经惊奇地发现，通过增加MRI成像剂的亲油性，大大提高了针对不同类型的身体组织的能力。 本发明的复合物提供增强的成像。 的动脉和静脉，以及肾组织成像。

公开(公告)号：WO03054278A2

公开(公告)日：2003-07-03

申请号：PCT/US0240650

申请日：2002-12-19

Applicant: PROCTER & GAMBLE

Inventor： SCHEPER WILLIAM MICHAEL ,  PERKINS CHRISTOPHER MARK

IPC: D06L1/04 ,  D06L1/00 ,  D06L1/02 ,  D06M10/00 ,  D06M13/192 ,  D06M13/513

CPC classification number: D06L1/02 ,  D06L1/00 ,  D06L1/04

Abstract: Methods and compositions to treat fabrics with lipophilic fluid and a hydrophobic chelant are provided by the present invention.

Abstract translation: 用亲脂性流体和疏水螯合剂处理织物的方法和组合物由本发明提供。

公开(公告)号：WO9700128A3

公开(公告)日：1997-04-17

申请号：PCT/US9608662

申请日：1996-06-04

Applicant: PROCTER & GAMBLE

Inventor： PERKINS CHRISTOPHER MARK

IPC: B01J31/18 ,  C07F15/06 ,  B01J

CPC classification number: C07F15/065

Abstract: A method for manufacturing cobalt complexes having the formula: [Co(NH3)5M] Ty wherein M ligands are selected from substituted and unsubstituted C1-C30 carboxylic acids having the formula: RC(O)O-; said method comprising reacting cobalt complexes having the formula: [Co(NH3)5X] Ty (e.g., X is chlorine) with concentrated ammonium hydroxide followed by carboxylic acid anhydride of the formula: RC(O)O(O)CR.

公开(公告)号：WO0226748A3

公开(公告)日：2002-06-27

申请号：PCT/US0129262

申请日：2001-09-19

Applicant: PROCTER & GAMBLE

Inventor： PERKINS CHRISTOPHER MARK

IPC: C07D487/08 ,  A61K51/00 ,  A61K51/04 ,  A61P35/00 ,  C07F1/08 ,  C07F5/00 ,  C07F7/00 ,  C07F9/68 ,  C07F11/00 ,  C07F13/00 ,  C07F15/00 ,  C07F15/02 ,  C07F15/04 ,  C07F15/06 ,  A61K31/30 ,  A61K49/00

CPC classification number: C07F15/045 ,  A61K51/0478 ,  C07F1/08 ,  C07F5/003 ,  C07F7/003 ,  C07F9/68 ,  C07F11/005 ,  C07F13/005 ,  C07F15/0013 ,  C07F15/0026 ,  C07F15/004 ,  C07F15/0053 ,  C07F15/0066 ,  C07F15/008 ,  C07F15/0093 ,  C07F15/025 ,  C07F15/065

Abstract: The first aspect of the present invention relates to transition metal complexes having the formula (I) or (II) wherein M is a radioactive metal having a valence of +2, +3, +4, or +5; m designates the charge of the metal complex, each R is independently C1-C8 linear or branched alkyl, a fifth ligand, and mixtures thereof; B is a bridging unit which comprises at least 2 carbon atoms; L is a pharmaceutically acceptable ligand; X is a pharmaceutically compatible anion in sufficient amount to provide electronic neutrality. The complexes of the present invention are suitable for use in diagnostic, therapeutic or radiotherapeutic or chemotherapeutic compositions for visualization, therapy, chemotherapy or radiotherapy of tissues or organs.

Abstract translation: 本发明的第一方面涉及具有式（I）或（II）的过渡金属配合物，其中M是具有+2，+ 3，+ 4或+5的化合价的放射性金属; m +表示金属络合物的电荷，每个R独立地为C 1 -C 8直链或支链烷基，第五配体及其混合物; B是包含至少2个碳原子的桥连单元; L是药学上可接受的配体; X是足以提供电子中性的药学上相容的阴离子。 本发明的复合物适用于诊断，治疗或放射治疗或化学治疗组合物用于组织或器官的可视化，治疗，化疗或放疗。

公开(公告)号：WO0032601A3

公开(公告)日：2000-10-05

申请号：PCT/US9927316

申请日：1999-11-18

Applicant: PROCTER & GAMBLE ,  HILER GEORGE DOUGLAS II ,  PERKINS CHRISTOPHER MARK

Inventor： HILER GEORGE DOUGLAS II ,  PERKINS CHRISTOPHER MARK

IPC: B01J31/18 ,  C07B61/00 ,  C07D487/08 ,  C07F13/00

CPC classification number: C07F13/005 ,  B01J31/182 ,  B01J2531/72 ,  B01J2531/96 ,  C07D487/08

Abstract: The present invention relates to a process for preparing a cross-bridged tetraaza macrocyclic ligand having formula (I) wherein each R is independently C1-C8 linear or branched alkyl, -(CH2)xCO2M, and mixtures thereof; provided both of the R units are not methyl; M is hydrogen or a salt forming cation; x is from 1 to 6; each index n is independently from 0 to 3; by contacting a di-quaternary cis tetracycle precursor with hydrogen in the presence of a palladium catalyst in an aqueous solution having a pH of at least about 10 at a temperature of about 40 DEG C to about 100 DEG C.

Abstract translation: 本发明涉及一种制备具有式（I）的交叉桥联四氮杂大环配体的方法，其中每个R独立地为C 1 -C 8直链或支链烷基， - （CH 2）x CO 2 M及其混合物; 提供的两个R单元都不是甲基; M是氢或形成盐的阳离子; x为1〜6; 每个指数n独立于0至3; 在钯催化剂存在下，在约40℃至约100℃的温度下，在pH为至少约10的水溶液中使二季顺式四环前体与氢接触。

公开(公告)号：WO9839406A9

公开(公告)日：1999-09-16

申请号：PCT/IB9800300

申请日：1998-03-06

Applicant: PROCTER & GAMBLE ,  UNIV KANSAS ,  BUSCH DARYLE HADLEY ,  COLLINSON SIMON ROBERT ,  HUBIN TIMOTHY JAY ,  LABEQUE REGINE ,  WILLIAMS BARBARA KAY ,  JOHNSTON JAMES PYOTT ,  KITKO DAVID JOHNATHAN ,  BURCKETT ST LAURENT JAMES CHAR ,  PERKINS CHRISTOPHER MARK

Inventor： BUSCH DARYLE HADLEY ,  COLLINSON SIMON ROBERT ,  HUBIN TIMOTHY JAY ,  LABEQUE REGINE ,  WILLIAMS BARBARA KAY ,  JOHNSTON JAMES PYOTT ,  KITKO DAVID JOHNATHAN ,  BURCKETT-ST LAURENT JAMES CHAR ,  PERKINS CHRISTOPHER MARK

IPC: C11D20060101 ,  C11D3/16 ,  C11D3/39 ,  C11D3/395 ,  D06L20060101

CPC classification number: C11D3/3935 ,  C11D3/168 ,  C11D3/3932 ,  C11D3/3942 ,  C11D3/3945

Abstract: Laundry or cleaning composition comprising: (a) a catalytically effective amount, preferably from about 1 ppb to about 99.9 %, of a transition-metal bleach catalyst which is a complex of a transition-metal and a cross-bridged macropolycyclic ligand; and (b) at least about 0.1 % of one or more laundry or cleaning adjunct materials, preferably comprising an oxygen bleaching agent. Preferred compositions are laundry compositions and automatic dishwashing detergents which provide enhanced cleaning/bleaching benefits through the use of such catalysts.

Abstract translation: 洗衣或清洁组合物，其包含：（a）催化有效量，优选约1ppb至约99.9％的过渡金属漂白催化剂，其为过渡金属和交叉桥联的大多环配体的络合物; 和（b）至少约0.1％的一种或多种衣物或清洁辅助材料，优选包含氧漂白剂。 优选的组合物是洗衣组合物和自动餐具洗涤剂，其通过使用这种催化剂提供增强的清洁/漂白益处。