公开(公告)号：WO2017087710A3

公开(公告)日：2017-05-26

申请号：PCT/US2016/062595

申请日：2016-11-17

申请人： PROVIVI, INC. ,  ONDI, Levente ,  MEHDI, Hasan

发明人： ONDI, Levente ,  MEHDI, Hasan ,  WAMPLER, Keith M. ,  MEINHOLD, Peter ,  COELHO, Pedro ,  BUI, Vu

IPC分类号： C07C6/02 ,  C07C6/04

摘要： The invention provides a method for synthesizing a fatty olefin derivative. In some embodiments, the method includes: a) contacting an unsaturated olefin with an unsaturated fatty acid ester in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product and b) converting the metathesis product to the fatty olefin derivative. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is an insect pheromone. Pheromone compositions and methods of using them are also described.

公开(公告)号：WO2017087710A2

公开(公告)日：2017-05-26

申请号：PCT/US2016/062595

申请日：2016-11-17

申请人： PROVIVI, INC. ,  ONDI, Levente ,  MEHDI, Hasan

发明人： ONDI, Levente ,  MEHDI, Hasan ,  WAMPLER, Keith M. ,  MEINHOLD, Peter ,  COELHO, Pedro ,  BUI, Vu

IPC分类号： C07C67/293 ,  C07C69/533

CPC分类号： B01J31/2278 ,  B01J2231/543 ,  B01J2531/64 ,  B01J2531/66 ,  C07B2200/09 ,  C07C6/04 ,  C07C29/147 ,  C07C45/41 ,  C07C67/08 ,  C07C67/293 ,  C07C67/343 ,  C07C2531/22 ,  C07C69/533 ,  C07C33/025 ,  C07C69/145 ,  C07C47/21 ,  C07C11/21

摘要： The invention provides a method for synthesizing a fatty olefin derivative. In some embodiments, the method includes: a) contacting an unsaturated olefin with an unsaturated fatty acid ester in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product and b) converting the metathesis product to the fatty olefin derivative. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is an insect pheromone. Pheromone compositions and methods of using them are also described.

摘要翻译： 本发明提供了用于合成脂肪烯烃衍生物的方法。 在一些实施方案中，该方法包括：a）在足以形成复分解产物的条件下，在易位催化剂存在下，使不饱和烯烃与不饱和脂肪酸酯接触，和b）将复分解产物转化为脂肪烯烃衍生物。 在某些实施方案中，复分解催化剂是钨催化剂或钼催化剂。 在不同的实施方案中，脂肪烯烃衍生物是昆虫信息素。 还介绍了信息素组合物及其使用方法。

公开(公告)号：WO2016210352A2

公开(公告)日：2016-12-29

申请号：PCT/US2016/039399

申请日：2016-06-24

申请人： PROVIVI, INC.

发明人： BUI, Vu ,  COELHO, Pedro ,  CHEN, Mike M.Y. ,  MEINHOLD, Peter ,  HEEL, Thomas

IPC分类号： C12P7/04 ,  C07C27/02

CPC分类号： C12P7/04 ,  C07C29/147 ,  C07C67/08 ,  C07C67/327 ,  C07C67/343 ,  C12P7/24 ,  C12P7/6436 ,  C12Y114/14001 ,  C12Y114/15003 ,  C07C69/675 ,  C07C69/533 ,  C07C33/025 ,  C07C69/145

摘要： The present invention provides a method for synthesizing an oxyfunctionalized product. The method includes incubating an enzyme substrate with an enzyme capable of hydroxylating one terminal carbon of the enzyme substrate to form a hydroxylated product and converting at least a portion of the hydroxylated product to the oxyfunctionalized product. The enzyme substrate is an unsaturated or saturated carboxylic acid or an ester thereof, and the hydroxylated product can be a terminal hydroxy-substituted unsaturated carboxylic acid or an ester thereof. The oxy-functionalized products include insect pheromones and other useful compounds.

摘要翻译： 本发明提供一种合成氧化产物的方法。 该方法包括使酶底物与能够使酶底物的一个末端碳羟化的酶形成羟基化产物并将至少一部分羟基化产物转化为氧化官能化产物。 酶底物是不饱和或饱和的羧酸或其酯，羟基化产物可以是末端羟基取代的不饱和羧酸或其酯。 氧官能化产物包括昆虫信息素和其它有用的化合物。

公开(公告)号：WO2018150379A3

公开(公告)日：2018-08-23

申请号：PCT/IB2018/050980

申请日：2018-02-17

申请人： PROVIVI, INC.

发明人： WAMPLER, Keith M. ,  BUI, Vu ,  ROZZELL, David ,  COELHO, Pedro ,  FLORUTI, Arthur ,  ONDI, Levente ,  MEHDI, Hasan ,  EROS, Gabor

IPC分类号： C07C29/00

摘要： Methods for preparation of olefins, including 8- and 11-unsaturated monoenes and polyenes, via transition metathesis-based synthetic routes are described. Metathesis reactions in the methods are catalyzed by transition metal catalysts including tungsten-, molybdenum-, and ruthenium-based catalysts. The olefins include insect pheromones useful in a number of agricultural applications.

公开(公告)号：WO2018150379A2

公开(公告)日：2018-08-23

申请号：PCT/IB2018/050980

申请日：2018-02-17

申请人： PROVIVI, INC.

发明人： WAMPLER, Keith M. ,  BUI, Vu ,  ROZZELL, David ,  COELHO, Pedro ,  FLORUTI, Arthur ,  ONDI, Levente ,  MEHDI, Hasan ,  EROS, Gabor

IPC分类号： C07C57/03 ,  C07C51/347

摘要： Methods for preparation of olefins, including 8- and 11-unsaturated monoenes and polyenes, via transition metathesis-based synthetic routes are described. Metathesis reactions in the methods are catalyzed by transition metal catalysts including tungsten-, molybdenum-, and ruthenium-based catalysts. The olefins include insect pheromones useful in a number of agricultural applications.

公开(公告)号：WO2017214133A2

公开(公告)日：2017-12-14

申请号：PCT/US2017/036136

申请日：2017-06-06

申请人： PROVIVI, INC.

发明人： OTTE, Konrad ,  SHEPPARD, Micah ,  BUI, Vu ,  WAMPLER, Keith ,  LEONARD, Effendi

IPC分类号： C07C29/136

摘要： The present application relates to methods of producing one or more fatty alcohols and/or one or more fatty aldehydes from one or more unsaturated lipid moieties by combining the obtainment or production of the one or more unsaturated lipid moieties from a biological source with conversion by non-biological means of the one or more unsaturated lipid moieties to one or more fatty alcohols and/or one or more fatty aldehydes. The present application also relates to recombinant microorganisms having a biosynthesis pathway for the production of one or more unsaturated lipid moieties. The one or more fatty alcohols can further be chemically converted to one or more corresponding fatty acetates. The one or more fatty alcohols, one or more fatty aldehydes and/or one or more fatty acetates produced by the methods described herein may be one or more insect pheromones, one or more fragrances, one or more flavoring agents, or one or more polymer intermediates.

摘要翻译： 本申请涉及通过组合获得或生产一种或多种不饱和脂质部分而由一种或多种不饱和脂质部分生产一种或多种脂肪醇和/或一种或多种脂肪醛的方法 通过非生物手段将一种或多种不饱和脂质部分转化成一种或多种脂肪醇和/或一种或多种脂肪醛。 本申请还涉及具有用于生产一种或多种不饱和脂质部分的生物合成途径的重组微生物。 一种或多种脂肪醇可以进一步化学转化为一种或多种相应的脂肪酸乙酯。 通过本文所述的方法产生的一种或多种脂肪醇，一种或多种脂肪醛和/或一种或多种脂肪酸乙酯可以是一种或多种昆虫信息素，一种或多种香料，一种或多种调味剂或一种或多种聚合物 中间体。

公开(公告)号：WO2015176020A1

公开(公告)日：2015-11-19

申请号：PCT/US2015/031219

申请日：2015-05-15

申请人： PROVIVI, INC.

发明人： COELHO, Pedro ,  CHEN, Mike M.Y. ,  MEINHOLD, Peter ,  CHO, Catherine Mee-Hie ,  BUI, Vu ,  HEEL, Thomas

IPC分类号： C07C29/04 ,  C07C29/50

CPC分类号： C12P7/04 ,  C07C1/34 ,  C07C2/861 ,  C07C5/09 ,  C07C6/04 ,  C07C29/32 ,  C07C45/29 ,  C07C51/235 ,  C07C67/14 ,  C07C2523/44 ,  C07C2531/22 ,  C07C2531/24 ,  C12P5/026 ,  C12P7/6418 ,  C07C33/025 ,  C07C69/145 ,  C07C11/02 ,  C07C11/22

摘要： In certain aspects, the present invention provides methods for producing terminally hydroxylated alkenes and alkynes by contacting an unsaturated or saturated hydrocarbon substrate with a hydroxylase enzyme. Exemplary terminal hydroxylases useful for carrying out the methods of the invention exhibit strong selectivity towards one terminal carbon of a hydrocarbon substrate and include, but are not limited to, non-heme diiron alkane monooxygenases, cytochromes P450 ( e.g. , cytochromes P450 of the CYP52 and CYP153 family), as well as long chain alkane hydroxylases. In some embodiments, the terminally hydroxylated alkene or alkyne is further converted to a terminal alkenal. In certain embodiments, terminally hydroxylated alkenes and alkynes are useful as insect pheromones which modify insect behavior. In other embodiments, terminally hydroxylated alkenes and alkynes are useful intermediates for producing pheromones via acetylation or oxidation of the alcohol moiety.

摘要翻译： 在某些方面，本发明提供通过使不饱和或饱和烃底物与羟化酶接触来制备末端羟基化的烯烃和炔烃的方法。 可用于实施本发明方法的示例性末端羟化酶对烃底物的一个末端碳表现出强选择性，包​​括但不限于非血红素二烷基烷烃单加氧酶，细胞色素P450（例如，CYP52的细胞色素P450和 CYP153家族），以及长链烷烃羟化酶。 在一些实施方案中，末端羟基化的烯烃或炔烃进一步转化成末端烯烃。 在某些实施方案中，末端羟基化的烯烃和炔烃可用作改变昆虫行为的昆虫信息素。 在其它实施方案中，末端羟基化的烯烃和炔烃是用于通过乙醇化部分的乙酰化或氧化产生信息素的有用中间体。