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公开(公告)号：WO2022104158A2
公开(公告)日：2022-05-19
申请号：PCT/US2021/059269
申请日：2021-11-12
Applicant: PULSE BIOSCIENCES, INC.
Inventor： MOSS, Kevin, L. , CONNOLLY, Richard, J. , DANITZ, David, J. , LEVINSON, Mitchell, E. , UECKER, Darrin, R. , HINMAN, Cameron, D.
IPC: A61B18/14 , A61B18/12 , A61B18/00 , A61B18/1206 , A61B18/1492 , A61B2018/0016 , A61B2018/0022 , A61B2018/00327 , A61B2018/00488 , A61B2018/00494 , A61B2018/00577 , A61B2018/00613 , A61B2018/00982
Abstract: Described herein are elongate applicator tools adapted to be inserted into an anatomical structure of a body to deliver electric treatment, for example, high voltage, sub-microsecond electrical energy, to a target tissue. These applicator tools may be configured for insertion into a blood vessel, an otolaryngological structure (such as an ear, nose, or throat, including anatomical structures, such as a turbinate, tonsils, tongue, soft palate, parotid glands, esophageal glands), a gastrointestinal tract (e.g., stomach, small intestine, large intestine, duodenum, colon, etc., including the esophagus), structures of the female reproductive system (e.g., fallopian tubes, uterus), and/or a respiratory tract (e.g., trachea, pharynx, larynx, and bronchi). Also disclosed herein are systems including these tools and methods of their operation.
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公开(公告)号：WO2020191301A1
公开(公告)日：2020-09-24
申请号：PCT/US2020/023882
申请日：2020-03-20
Applicant: PULSE BIOSCIENCES, INC.
Inventor： EBBERS, Edward, A. , UECKER, Darrin, R. , NUCCITELLI, Richard, L.
Abstract: Described herein are methods and apparatuses for the application of electric energy treatment(s) to skin tissue to alter pigmentation, and in particular to remove a tattoo. These methods and apparatuses may deliver pulsed electrical energy having a pulse duration in submicrosecond pulse range to provide high-field strength pulses that may effectively release tattoo ink and allow removal of tattoo ink regardless of ink color or composition.
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公开(公告)号：WO2019143577A1
公开(公告)日：2019-07-25
申请号：PCT/US2019/013545
申请日：2019-01-14
Applicant: PULSE BIOSCIENCES, INC.
Inventor： DANITZ, David, J. , HINMAN, Cameron, D. , KRIEG, Kenneth, R. , MOSS, Kevin, L. , FOSTER, Christopher, J. , UECKER, Darrin, R.
CPC classification number: A61N1/0502 , A61B18/1445 , A61B34/32 , A61B34/37 , A61B2018/1425 , A61B2018/1432 , A61N1/40
Abstract: Described herein are methods and systems for using the treatment tip apparatuses and high-voltage connectors with robotic surgical systems. For example, retractable treatment tip apparatuses (e.g., devices, systems, etc.) including one or a plurality of electrodes that are protected by a housing (which may be retractable) until pressed against the tissue for deployment of the electrodes and delivery of a therapeutic treatment, are disclosed. In particular, these apparatuses may include a plurality of treatment electrodes and may be configured for the delivery of nanosecond pulsed electric fields. Also described herein are high-voltage connectors configured to provide high-voltage energy, such as nsPEF pulses, from a generator to the retractable treatment tip apparatuses.
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公开(公告)号：WO2019032474A1
公开(公告)日：2019-02-14
申请号：PCT/US2018/045433
申请日：2018-08-06
Applicant: PULSE BIOSCIENCES, INC.
Inventor： DANITZ, David, J. , HINMAN, Cameron, D. , EBBERS, Edward , NUCCITELLI, Richard, L. , MOSS, Kevin, L. , UECKER, Darrin, R.
Abstract: Methods and apparatuses for treating a tissue with an electric treatment by rotating a pattern of electrodes partway through a treatment is disclosed. Also described herein are methods and apparatuses to treat tissue, including treating skin disorders, by selectively de-nucleating epidermal cells without provoking a significant inflammatory response, e.g., without increasing the density of leukocytes in the treated skin, and without affecting the non-cellular components of the dermis.
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