公开(公告)号：WO2022271469A1

公开(公告)日：2022-12-29

申请号：PCT/US2022/033169

申请日：2022-06-13

Applicant: PULSE BIOSCIENCES, INC.

Inventor： MOSS, Kevin, L. ,  TREBOTICH, Steven, H. ,  DANITZ, David, J.

IPC: A61B18/14 ,  A61N1/05 ,  A61B18/1402 ,  A61N1/0502

Abstract: Applicators and methods including electrodes that are configured to apply energy within the tissue while selectively applying vacuum to prevent arcing and/or to enhance deployment of the electrodes into the tissue are provided. The applicators may comprise vacuum ports around the electrodes of the applicators and may be also comprise an internal vacuum source.

公开(公告)号：WO2023019108A1

公开(公告)日：2023-02-16

申请号：PCT/US2022/074666

申请日：2022-08-08

Applicant: PULSE BIOSCIENCES, INC.

Inventor： MOSS, Kevin, L. ,  DANITZ, David, J. ,  CONNOLLY, Richard, J. ,  WEILBACHER, Katherine, P. ,  HINMAN, Cameron, D.

IPC: A61N1/32 ,  A61B18/14

Abstract: Treatment applicators and methods including treatment applicators for delivering electrical energy to a target tissue that are configured to reduce or eliminate arcing as well as provide enhance targeting to tissue surfaces or regions just below the surface of the tissue.

公开(公告)号：WO2019143577A1

公开(公告)日：2019-07-25

申请号：PCT/US2019/013545

申请日：2019-01-14

Applicant: PULSE BIOSCIENCES, INC.

Inventor： DANITZ, David, J. ,  HINMAN, Cameron, D. ,  KRIEG, Kenneth, R. ,  MOSS, Kevin, L. ,  FOSTER, Christopher, J. ,  UECKER, Darrin, R.

IPC: A61B34/30 ,  A61B18/14 ,  A61N1/36 ,  A61N1/40 ,  A61B18/00

CPC classification number: A61N1/0502 ,  A61B18/1445 ,  A61B34/32 ,  A61B34/37 ,  A61B2018/1425 ,  A61B2018/1432 ,  A61N1/40

Abstract: Described herein are methods and systems for using the treatment tip apparatuses and high-voltage connectors with robotic surgical systems. For example, retractable treatment tip apparatuses (e.g., devices, systems, etc.) including one or a plurality of electrodes that are protected by a housing (which may be retractable) until pressed against the tissue for deployment of the electrodes and delivery of a therapeutic treatment, are disclosed. In particular, these apparatuses may include a plurality of treatment electrodes and may be configured for the delivery of nanosecond pulsed electric fields. Also described herein are high-voltage connectors configured to provide high-voltage energy, such as nsPEF pulses, from a generator to the retractable treatment tip apparatuses.

公开(公告)号：WO2022104158A2

公开(公告)日：2022-05-19

申请号：PCT/US2021/059269

申请日：2021-11-12

Applicant: PULSE BIOSCIENCES, INC.

Inventor： MOSS, Kevin, L. ,  CONNOLLY, Richard, J. ,  DANITZ, David, J. ,  LEVINSON, Mitchell, E. ,  UECKER, Darrin, R. ,  HINMAN, Cameron, D.

IPC: A61B18/14 ,  A61B18/12 ,  A61B18/00 ,  A61B18/1206 ,  A61B18/1492 ,  A61B2018/0016 ,  A61B2018/0022 ,  A61B2018/00327 ,  A61B2018/00488 ,  A61B2018/00494 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00982

Abstract: Described herein are elongate applicator tools adapted to be inserted into an anatomical structure of a body to deliver electric treatment, for example, high voltage, sub-microsecond electrical energy, to a target tissue. These applicator tools may be configured for insertion into a blood vessel, an otolaryngological structure (such as an ear, nose, or throat, including anatomical structures, such as a turbinate, tonsils, tongue, soft palate, parotid glands, esophageal glands), a gastrointestinal tract (e.g., stomach, small intestine, large intestine, duodenum, colon, etc., including the esophagus), structures of the female reproductive system (e.g., fallopian tubes, uterus), and/or a respiratory tract (e.g., trachea, pharynx, larynx, and bronchi). Also disclosed herein are systems including these tools and methods of their operation.

公开(公告)号：WO2022051178A1

公开(公告)日：2022-03-10

申请号：PCT/US2021/047879

申请日：2021-08-27

Applicant: PULSE BIOSCIENCES, INC.

Inventor： HINMAN, Cameron, D. ,  MOSS, Kevin, L. ,  JOE, Wesley, C. ,  ROBINO, Peter, H.

IPC: A61B18/14 ,  A61B18/00 ,  A61B18/12

Abstract: Methods and apparatuses (e.g., devices, instruments and systems, including applicator handles for use with pulse generators) for automatically and/or mechanically setting impedance matching for connecting the applicator handle with different electrode tips. These methods and apparatuses may be useful for applying therapeutic energy, including but not limited to short, high field strength electric pulses, while avoiding the risk of arcing or otherwise harming the tissue.

公开(公告)号：WO2023076767A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/076507

申请日：2022-09-15

Applicant: PULSE BIOSCIENCES, INC.

Inventor： MOSS, Kevin, L. ,  HINMAN, Cameron, D. ,  DUENAS, Bryan ,  DANITZ, David, J.

IPC: A61B18/14

Abstract: Described herein are percutaneous treatment tools and methods for applying electric treatment to a target tissue, hi some examples the treatment tools described herein allow for adjusting the spacing between the proximal electrode(s) and the distal electrode of the treatment tools. The treatment tools described herein may also be configured to reduce peak electric field for a given potential and/or to increase hoop stress on the tissue upon insertion of the tip to prevent or reduce arcing between the electrodes.

公开(公告)号：WO2019177987A1

公开(公告)日：2019-09-19

申请号：PCT/US2019/021649

申请日：2019-03-11

Applicant: PULSE BIOSCIENCES, INC.

Inventor： HINMAN, Cameron, D. ,  MOSS, Kevin, L. ,  DANITZ, David, J.

IPC: A61N1/36 ,  A61N1/05

Abstract: Electrodes that are configured to apply energy within the tissue while moving relative to the tissue. The apparatuses (devices, assemblies, systems) described herein may be configured with one or more electrodes that may move slightly in oscillatory movement and/or rotation relative to the tissue. The apparatuses described herein may be used to apply energy to a patient while minimizing or preventing the unintended modification of the tissue adjacent to the electrode, such as by arcing.

公开(公告)号：WO2019032474A1

公开(公告)日：2019-02-14

申请号：PCT/US2018/045433

申请日：2018-08-06

Applicant: PULSE BIOSCIENCES, INC.

Inventor： DANITZ, David, J. ,  HINMAN, Cameron, D. ,  EBBERS, Edward ,  NUCCITELLI, Richard, L. ,  MOSS, Kevin, L. ,  UECKER, Darrin, R.

IPC: A61B18/14 ,  A61N1/04 ,  A61N1/32

Abstract: Methods and apparatuses for treating a tissue with an electric treatment by rotating a pattern of electrodes partway through a treatment is disclosed. Also described herein are methods and apparatuses to treat tissue, including treating skin disorders, by selectively de-nucleating epidermal cells without provoking a significant inflammatory response, e.g., without increasing the density of leukocytes in the treated skin, and without affecting the non-cellular components of the dermis.