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公开(公告)号：WO2021055621A1
公开(公告)日：2021-03-25
申请号：PCT/US2020/051293
申请日：2020-09-17
发明人： PAPAIOANNOU, Nikolaos , TRAVINS, Jeremy Mark , FINK, Sarah Jocelyn , ELLARD, John Mark , RAE, Alastair
IPC分类号： C07D471/04 , A61P9/00 , A61P29/00 , A61K31/437
摘要： The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
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公开(公告)号：WO2022197756A1
公开(公告)日：2022-09-22
申请号：PCT/US2022/020479
申请日：2022-03-16
发明人： PAPAIOANNOU, Nikolaos , TRAVINS, Jeremy Mark , FINK, Sarah Jocelyn , ELLARD, John Mark , RAE, Alastair , SPENCER, Jonathan Andrew
IPC分类号： A61P9/00 , A61P29/00 , C07D471/04 , C07D519/00 , A61K31/437
摘要： The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
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公开(公告)号：WO2021055589A1
公开(公告)日：2021-03-25
申请号：PCT/US2020/051249
申请日：2020-09-17
发明人： PAPAIOANNOU, Nikolaos , TRAVINS, Jeremy Mark , FINK, Sarah Jocelyn , ELLARD, John Mark , RAE, Alastair
IPC分类号： A61P29/02 , A61K31/495 , C07D519/00
摘要： The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
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公开(公告)号：WO2022197758A1
公开(公告)日：2022-09-22
申请号：PCT/US2022/020482
申请日：2022-03-16
发明人： PAPAIOANNOU, Nikolaos , TRAVINS, Jeremy Mark , FINK, Sarah Jocelyn , ELLARD, John Mark , RAE, Alastair , SPENCER, Jonathan Andrew , RANKIN, Stuart Shane , CHAPMAN, Robert Stuart Laurie
IPC分类号： A61P9/00 , C07D471/04 , A61K31/437 , A61P29/00
摘要： The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
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公开(公告)号：WO2022197755A1
公开(公告)日：2022-09-22
申请号：PCT/US2022/020474
申请日：2022-03-16
发明人： PAPAIOANNOU, Nikolaos , TRAVINS, Jeremy Mark , FINK, Sarah Jocelyn , ELLARD, John Mark , RAE, Alastair
IPC分类号： A61P9/00 , A61P29/00 , C07D471/04 , A61K31/437
摘要： The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
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公开(公告)号：WO2018144620A1
公开(公告)日：2018-08-09
申请号：PCT/US2018/016272
申请日：2018-01-31
IPC分类号： C07C235/38 , A61K31/167 , A61P17/00 , C07C235/40 , C07C237/20 , C07C255/60 , C07D205/04 , C07D207/12 , C07D207/24 , C07D209/46 , C07D211/22 , C07D211/26 , C07D211/46 , C07D211/58 , C07D213/30
摘要： Provided herein are anti-fibrotic compounds, in particular those of Formula (I), that inhibit the TGF-beta signaling pathway. Also provided are pharmaceutical compositions comprising the anti-fibrotic compounds, and methods of treating diseases or conditions associated with fibrosis, inflammation, and benign or malignant neoplastic diseases in a subject by administering a compound or composition described herein. (Formula (I))
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公开(公告)号：WO2022197789A1
公开(公告)日：2022-09-22
申请号：PCT/US2022/020527
申请日：2022-03-16
发明人： PAPAIOANNOU, Nikolaos , TRAVINS, Jeremy Mark , FINK, Sarah Jocelyn , ELLARD, John Mark , RAE, Alastair , RANKIN, Stuart Shane , CHAPMAN, Robert Stuart Laurie
IPC分类号： C07D471/04 , C07D487/04 , A61P9/00 , A61P29/00 , A61K31/437
摘要： The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
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公开(公告)号：WO2022197763A1
公开(公告)日：2022-09-22
申请号：PCT/US2022/020491
申请日：2022-03-16
发明人： PAPAIOANNOU, Nikolaos , TRAVINS, Jeremy Mark , FINK, Sarah Jocelyn , ELLARD, John Mark , RAE, Alastair
IPC分类号： A61P9/00 , A61P29/00 , C07D417/12 , C07D417/14 , C07D471/04 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D487/04 , C07D495/04 , A61K31/437
摘要： The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
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公开(公告)号：WO2019178129A1
公开(公告)日：2019-09-19
申请号：PCT/US2019/021897
申请日：2019-03-12
发明人： PAPAIOANNOU, Nikolaos , FINK, Sarah Jocelyn , MILLER, Thomas Allen , SHIPPS, Gerald Wayne, Jr. , TRAVINS, Jeremy Mark , EHMANN, David Edward , RAE, Alastair , ELLARD, John Mark
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , C07D519/00 , A61P9/00
摘要： The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
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