公开(公告)号：WO2021248124A1

公开(公告)日：2021-12-09

申请号：PCT/US2021/036194

申请日：2021-06-07

Applicant: SNAPDRAGON CHEMISTRY, INC.

Inventor： AMADOR, Adrian G. ,  FANG, Yuanqing ,  FORD, David D. ,  GONCHARUK, Mikhail V. ,  RUSSELL, Grace

IPC: G01N30/06 ,  G01N1/38 ,  G01N30/88 ,  G01N30/20 ,  G01N1/2035 ,  G01N2001/205 ,  G01N2030/027 ,  G01N2030/324 ,  G01N2030/8435 ,  G01N2030/8804 ,  G01N2030/8809 ,  G01N2030/8886 ,  G01N30/04 ,  G01N30/30 ,  G01N30/32 ,  G01N30/84 ,  G01N30/8658

Abstract: The present disclosure relates to a computer-implemented method for analyzing a product stream of a chemical reaction. The method includes withdrawing a portion of the product stream of the chemical reaction from a reactor, the portion of the product stream having a volume of less than about 200 µL. The method further includes mixing the portion of the product stream with a diluent to produce a sample and then transferring the sample to a liquid chromatography device. A measured chemical profile is then developed, via the liquid chromatography device, which can be used for process monitoring or real time decision making. In some embodiments, the method can include adjusting a reaction condition in the reactor based on differences between the measured chemical profile and a desired chemical profile.

公开(公告)号：WO2021026339A1

公开(公告)日：2021-02-11

申请号：PCT/US2020/045179

申请日：2020-08-06

Applicant: SNAPDRAGON CHEMISTRY, INC.

Inventor： AMADOR, Adrian G. ,  BIO, Matthew M. ,  DOHERTY, Timothy J. ,  FANG, Yuanqing ,  SHEERAN, Jillian ,  SPOERING, Ryan M.

IPC: B01J19/12

Abstract: Embodiments described herein relate generally to continuous flow photoreactors with easily replaceable and adjustable components. The photoreactor includes a reactor flow system, a lighting system, and a temperature control system. The reactor flow system includes a reactor inlet port, a reactor outlet port, and a length of reactor tubing fluidically coupled to the reactor inlet port and reactor outlet port. The lighting system includes a light emitting apparatus (e.g., a plurality of LEDs) configured to emit light in a defined wavelength range toward the length of reactor tubing. The temperature control system includes an inlet port, an outlet port, and a length of temperature control tubing fluidically coupled to the inlet port and the outlet port. In some embodiments, the temperature control system can be configured to circulate a fluid to cool the lighting system.