公开(公告)号：WO2021248124A1

公开(公告)日：2021-12-09

申请号：PCT/US2021/036194

申请日：2021-06-07

Applicant: SNAPDRAGON CHEMISTRY, INC.

Inventor： AMADOR, Adrian G. ,  FANG, Yuanqing ,  FORD, David D. ,  GONCHARUK, Mikhail V. ,  RUSSELL, Grace

IPC: G01N30/06 ,  G01N1/38 ,  G01N30/88 ,  G01N30/20 ,  G01N1/2035 ,  G01N2001/205 ,  G01N2030/027 ,  G01N2030/324 ,  G01N2030/8435 ,  G01N2030/8804 ,  G01N2030/8809 ,  G01N2030/8886 ,  G01N30/04 ,  G01N30/30 ,  G01N30/32 ,  G01N30/84 ,  G01N30/8658

Abstract: The present disclosure relates to a computer-implemented method for analyzing a product stream of a chemical reaction. The method includes withdrawing a portion of the product stream of the chemical reaction from a reactor, the portion of the product stream having a volume of less than about 200 µL. The method further includes mixing the portion of the product stream with a diluent to produce a sample and then transferring the sample to a liquid chromatography device. A measured chemical profile is then developed, via the liquid chromatography device, which can be used for process monitoring or real time decision making. In some embodiments, the method can include adjusting a reaction condition in the reactor based on differences between the measured chemical profile and a desired chemical profile.