公开(公告)号：WO2021262820A1

公开(公告)日：2021-12-30

申请号：PCT/US2021/038635

申请日：2021-06-23

Applicant: SAUDI ARABIAN OIL COMPANY ,  ARAMCO SERVICES COMPANY

Inventor： ROTH, Brian A.

IPC: E21B34/10 ,  E21B2200/05 ,  E21B34/14 ,  E21B34/16 ,  E21B47/06 ,  E21B47/07 ,  G01N1/2035 ,  G01N2001/205 ,  G01N33/2888

Abstract: A subsurface safety valve for controlling fluid flow in a wellbore including a monitoring sub having a hydraulic connection port and defining a piston bore. The monitoring sub defining a hydraulic circuit extending between the hydraulic connection port and the piston bore. The monitoring sub comprising a sensing assembly incorporated in the hydraulic circuit that is operable to measure a degradation level of fluid in the hydraulic circuit. A flapper sub attached to the monitoring sub. A piston disposed in the piston bore of the monitoring sub. A flow tube positioned between the monitoring sub and the flapper attached to a downhole end of the monitoring sub and in contact with the flapper, the flow tube having a protrusion in contact with the piston. A return spring positioned in a cavity defined between the flow tube and the flapper sub, biasing the flow tube towards the monitoring sub.

公开(公告)号：WO2021248124A1

公开(公告)日：2021-12-09

申请号：PCT/US2021/036194

申请日：2021-06-07

Applicant: SNAPDRAGON CHEMISTRY, INC.

Inventor： AMADOR, Adrian G. ,  FANG, Yuanqing ,  FORD, David D. ,  GONCHARUK, Mikhail V. ,  RUSSELL, Grace

IPC: G01N30/06 ,  G01N1/38 ,  G01N30/88 ,  G01N30/20 ,  G01N1/2035 ,  G01N2001/205 ,  G01N2030/027 ,  G01N2030/324 ,  G01N2030/8435 ,  G01N2030/8804 ,  G01N2030/8809 ,  G01N2030/8886 ,  G01N30/04 ,  G01N30/30 ,  G01N30/32 ,  G01N30/84 ,  G01N30/8658

Abstract: The present disclosure relates to a computer-implemented method for analyzing a product stream of a chemical reaction. The method includes withdrawing a portion of the product stream of the chemical reaction from a reactor, the portion of the product stream having a volume of less than about 200 µL. The method further includes mixing the portion of the product stream with a diluent to produce a sample and then transferring the sample to a liquid chromatography device. A measured chemical profile is then developed, via the liquid chromatography device, which can be used for process monitoring or real time decision making. In some embodiments, the method can include adjusting a reaction condition in the reactor based on differences between the measured chemical profile and a desired chemical profile.

公开(公告)号：WO2021228499A1

公开(公告)日：2021-11-18

申请号：PCT/EP2021/060101

申请日：2021-04-19

Applicant: ENDRESS+HAUSER CONDUCTA GMBH+CO. KG

Inventor： ENDRESS, Urs ,  WITTMER, Detlev ,  JAGIELLA, Manfred ,  ROMPF, Christoph ,  STEUERWALD, Ralf ,  EUBISCH, Angela ,  HANKO, Michael ,  LINDMÜLLER, Peter ,  SOMMER, Eckhard ,  MÖLLER, Robert ,  GRÄFE, Christine Marion ,  HEISTERKAMP, Monika

IPC: G01N1/18 ,  G01N1/20 ,  G01N1/40 ,  G01N21/65 ,  G01N33/18 ,  G01N33/543 ,  G01N33/569 ,  G01N35/00 ,  B01L3/00 ,  G01N1/2035 ,  G01N1/405 ,  G01N1/4077 ,  G01N2001/2071 ,  G01N2001/4083 ,  G01N21/658 ,  G01N33/1826 ,  G01N35/0098

Abstract: Die Erfindung betrifft eine automatische Probennahmevorrichtung (1) zur Entnahme von Flüssigkeitsproben einer an einer Probenentnahmestelle (12) eines Gewässers oder eines Behälters vorliegenden Probenflüssigkeit, insbesondere Wasser oder Abwasser, für die qualitative oder quantitative Bestimmung mindestens eines in der Probenflüssigkeit enthaltenen Analyten, insbesondere eines Biopolymers, umfassend: • eine mit der Probenentnahmestelle (12) fluidisch verbindbare Probenleitung (5); • eine Pumpeinrichtung (4); • mindestens einen mit der Probenleitung (5) fluidisch verbindbaren Probenbehälter (8); und eine Steuerelektronik (10), die dazu eingerichtet ist, die Probenleitung (5) fluidisch mit dem mindestens einen Probenbehälter (8) zu verbinden, so dass ein sich von der Probenentnahmestelle (12) durch die Probenleitung (5) in den Probenbehälter (8) erstreckender Fluidströmungspfad gebildet wird • und wobei die Steuerelektronik (10) weiter dazu eingerichtet ist, mittels der Pumpeinrichtung (5) ein vorgebbares Volumen der Probenflüssigkeit als Flüssigkeitsprobe entlang des Fluidströmungspfads in den Probenbehälter (8) zu transportieren, • wobei die Probenentnahmevorrichtung (1) Mittel (14, 17) zur Aufkonzentrierung und/oder Extraktion des in der Flüssigkeitsprobe vorliegenden Analyten aufweist.

公开(公告)号：WO2021144227A1

公开(公告)日：2021-07-22

申请号：PCT/EP2021/050395

申请日：2021-01-11

Applicant: SARTORIUS STEDIM BIOTECH GMBH

Inventor： GRIMM, Christian

IPC: G01N1/20 ,  B01D61/12 ,  G01N1/40 ,  B01D2311/04 ,  B01D2311/246 ,  B01D2311/2688 ,  B01D2313/90 ,  B01D2319/06 ,  B01D61/20 ,  G01N1/2035 ,  G01N2001/4016

Abstract: A filtration module (20) for filtering a process medium in a bioprocess, in particular in a biopharmaceutical process comprises a process flow path for a process medium, a filter membrane (20) coupled to the process flow path, and a sampling membrane (18) coupled both to the process flow path and to a sampling flow path (16) for extracting a sample from the process medium. The sampling flow path (16) guides the extracted sample to a sampling outlet of the filtration module (20) or to an analyzer integrated into the filtration module (20). A filtration assembly comprises such a filtration module and an analyzer coupled to the sampling outlet of the filtration module (20). A method of sampling during a bioprocess comprises the following steps: providing such a filtration module (20); urging a process medium through the process flow path; filtering the process medium by using the filter membrane (20) coupled to the process flow path; extracting a sample from the process medium by using the sampling membrane (18) coupled to both the process flow path and the sampling flow path (16); and guiding the extracted sample to a sampling outlet of the filtration module (20) or to an analyzer integrated into the filtration module (20). A computer program comprises instructions to effect at least one of the following: cause the means for urging the transport medium through the sampling flow path (16) of the filtration assembly to control the flow of the transport medium; control the analyzer of the filtration module (20) or the analyzer of the filtration assembly, especially providing settings and inputs to the analyzer; cause a process control unit of the filtration assembly to evaluate analysis data provided by the analyzer of the filtration module or the analyzer of the filtration assembly, and to adjust or control the bioprocess based on the evaluation.

公开(公告)号：WO2022238746A1

公开(公告)日：2022-11-17

申请号：PCT/IB2021/058401

申请日：2021-09-15

Applicant: HEGDE, Shreepad

Inventor： HEGDE, Shreepad

IPC: G01N1/14 ,  G01N1/2035 ,  G01N2001/1037 ,  G01N2001/2071

Abstract: A system (100) for sample collection is provided. The system (100) comprises an inner hub (102), having a cavity (114) with holes, encased in an outer casing (101), wherein the inner hub (102) having sealing (115) at the holes of the cavity (114), a rotary actuator (116) connected with the inner hub (102) via a connecting rod (103), configured to rotate the inner hub (102) along with the cavity (114), a first nozzle (107), having a first valve, configured to mount on a container containing a sample fluid, connected with the inner hub (102) via an inner nozzle (109), a second nozzle (108), having a second valve, configured to connect the cavity (114) with a source of compressed gas, a third nozzle (110), having a third valve, disposed on the outer casing (101), connecting the inner hub (102) with a sample bottle holder assembly (106) to collect the sample fluid.

公开(公告)号：WO2021262191A1

公开(公告)日：2021-12-30

申请号：PCT/US2020/039789

申请日：2020-06-26

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

Inventor： PUGLIESE, Roberto A. ,  CYR, Kathryn H. ,  DAY, Michael J. ,  HAMMERSTAD, Diane R.

IPC: G01N15/10 ,  G01N1/14 ,  G01N35/10 ,  G01N1/2035 ,  G01N1/40 ,  G01N15/0266 ,  G01N15/0656 ,  G01N2001/2064 ,  G01N35/1009

Abstract: In one example in accordance with the present disclosure, am ejection system is described. The ejection system includes a fluid feed slot to supply fluid to a number of fluid ejection channels where each fluid ejection channel is a recirculating channel. Each fluid ejection channel includes a sensor to detect, in the fluid, a target particle to be ejected and a fluid ejector to eject the target particle from the fluid ejection channel. The ejection system also includes a controller to selectively activate the fluid ejector when the target particle presence is detected. Non-target particles are returned to the fluid feed slot past the fluid ejector.

公开(公告)号：WO2021145985A1

公开(公告)日：2021-07-22

申请号：PCT/US2020/064403

申请日：2020-12-11

Applicant: EXXONMOBIL RESEARCH AND ENGINEERING COMPANY

Inventor： BAINBRIDGE, Samuel, C. ,  SENZER, Eric, B.

IPC: G01N1/02 ,  G01N1/10 ,  G01N1/20 ,  G01N1/2035 ,  G01N2001/1031 ,  G01N2001/2071

Abstract: Systems and processes for collecting and transporting a fluid sample. In one embodiment, the system can include at least one apparatus that can include a rotatable shaft, one or more other moving parts, and at least one fluid path containing a lubricating fluid. The system can also include at least one sample container and at least one unmanned aerial vehicle configured to transport the at least one sample container. The system can also include at least one valve that can be configured to open and discharge a sample of the lubricating fluid from the at least one fluid path into the at least one sample container. At least one unmanned aerial vehicle station can be configured to receive the at least one unmanned aerial vehicle. At least one retention and loading mechanism can be configured to move the at least one sample container.