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    LEAFLET ABRASION MITIGATION IN PROSTHETIC HEART VALVES
    1.
    发明申请
    LEAFLET ABRASION MITIGATION IN PROSTHETIC HEART VALVES 审中-公开
    前列腺切除术中的叶片磨损减轻

    公开(公告)号：WO2015160675A1

    公开(公告)日：2015-10-22

    申请号：PCT/US2015/025499

    申请日：2015-04-13

    申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.

    发明人： BRAIDO, Peter N. ,  SMITH, Kent J. ,  MCCARTHY, Andrea L. ,  FAHIM, Mina S.

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2412 ,  A61F2/2418 ,  A61F2220/0075 ,  A61F2250/0021

    摘要： A prosthetic heart valve (600) includes a stent (602) extending in a longitudinal direction, the stentbeing formed of a plurality of struts (603) forming cells (612) and having a plurality of commissure features, a collapsed condition and an expanded condition. A valve assembly may be secured to the stent, the valve assembly including a cuff (606) and a plurality of leaflets. The cuff (may be formed of a fabric and a second material (650) different from the fabric, the cuff having commissure peaks and a plurality of midpeaks disposed between the commissure peaks. Each of the leaflets may have a free edge. The prosthetic heart valve may also comprise buffer strips wrapped around stuts of the stent. The portion of the cuff may also be disposed on the abluminal surface of the stent.

    摘要翻译： 假体心脏瓣膜（600）包括沿纵向方向延伸的支架（602），支架由多个支柱（603）形成，形成细胞（612）并具有多个连合特征，折叠状态和扩张状态 。 阀组件可以固定到支架上，阀组件包括袖带（606）和多个传单。 袖口（可以由织物和不同于织物的第二材料（650）形成，袖带具有连合峰和设置在接合峰之间的多个中峰，每个传单可以具有自由边缘，假体心脏 阀还可以包括缠绕在支架的支柱周围的缓冲带。箍的一部分也可以设置在支架的外侧表面上。

    PARAVALVULAR SEALING VIA EXTENDED CUFF MECHANISMS
    2.
    发明申请
    PARAVALVULAR SEALING VIA EXTENDED CUFF MECHANISMS 审中-公开
    通过扩展的机构间隔密封

    公开(公告)号：WO2015152980A1

    公开(公告)日：2015-10-08

    申请号：PCT/US2015/011387

    申请日：2015-01-14

    申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.

    发明人： BRAIDO, Peter N. ,  ALKHATIB, Yousef F. ,  ANDERL, Steven Frederick ,  DALY, Jacob John ,  FAHIM, Mina S. ,  SMITH, Kent J. ,  THOMAS, Ralph Joseph

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2250/0069

    摘要： A prosthetic heart valve 300 may include a collapsible and expandable stent 306 having a proximal end 302, a distal end 304, an annulus section adjacent the proximal end, and a plurality of cells connected to one another in annular rows around the stent, a cuff 312 attached to the stent, and a sealing member 322 attached to the cuff and extending from a proximal end 313 of the cuff to a free edge 323. The sealing member 322 may be movable between an extended condition in which the free edge 323 is located proximally of the proximal end 302 of the stent 306, and an inverted condition in which the free edge is located distally of the proximal end of the stent and a first surface 324 of the sealing member confronts an outward-facing surface of the cuff. Various mechanisms for moving the sealing member 322 are also described.

    摘要翻译： 假体心脏瓣膜300可以包括可折叠和可扩张的支架306，其具有近端302，远端304，邻近近端的环形部分，以及围绕支架以环形排彼此连接的多个细胞，袖带 312，并且附接到袖带并从袖带的近端313延伸到自由边缘323的密封构件322.密封构件322可以在自由边缘323位于的延伸状态之间移动 支架306的近端302的近侧，以及其中自由边缘位于支架的近端的远侧的倒置状态，并且密封构件的第一表面324面向袖带的向外的表面。 还描述了用于移动密封构件322的各种机构。

    LEAFLET-CUFF ATTACHMENTS FOR PROSTHETIC HEART VALVE
    3.
    发明申请
    LEAFLET-CUFF ATTACHMENTS FOR PROSTHETIC HEART VALVE 审中-公开
    用于前置心脏瓣膜的LEAFLET-CUFF附件

    公开(公告)号：WO2015094936A1

    公开(公告)日：2015-06-25

    申请号：PCT/US2014/069886

    申请日：2014-12-12

    申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.

    发明人： BRAIDO, Peter N. ,  SCHRAUT, Julia A. ,  FAHIM, Mina S. ,  PARA, Andrea N. ,  SMITH, Kent J.

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2/2442 ,  A61F2/2445 ,  A61F2/2469 ,  A61F2220/0016 ,  A61F2220/0075

    摘要： A prosthetic heart valve includes a stent having a collapsed condition and an expanded condition, the stent having a proximal end, a distal end and a plurality of commissure features. The heart valve further includes a valve assembly secured to the stent, the valve assembly including a cuff and a plurality of leaflets (1408), each of the leaflets having a free edge (1410) having a first end (1412) and a second end (1412), and a second edge (1414) secured to the cuff, the second edge (1414) having a first end, a second end, a first folded portion (1420) adjacent the first end, a second folded portion (1420) adjacent the second end, and an unfolded portion between the first and second folded portions. The first and second folded portions couple the leaflet to ones of the commissure features. The leaflet comprises a reverse- running stitch that follows the curvature of the unfolded portion and acts as a reinforcement.

    摘要翻译： 假体心脏瓣膜包括具有塌陷状态和扩张状态的支架，所述支架具有近端，远端和多个连合部件。 心脏瓣膜还包括固定在支架上的阀组件，阀组件包括一个袖带和多个小叶（1408），每个小叶具有一个具有第一端（1412）的自由边缘（1410）和第二端 （1412）和固定到所述袖带的第二边缘（1414），所述第二边缘（1414）具有第一端部，第二端部，邻近所述第一端部的第一折叠部分（1420），第二折叠部分（1420） 邻近第二端，以及在第一和第二折叠部分之间的展开部分。 第一和第二折叠部分将传单联接到联合特征中的一个。 该小叶包括跟随展开部分的曲率的反向运动针迹，并且用作加强件。

    CUFF STITCHING REINFORCEMENT
    4.
    发明申请
    CUFF STITCHING REINFORCEMENT 审中-公开
    CUFF刺绣加固

    公开(公告)号：WO2015080929A1

    公开(公告)日：2015-06-04

    申请号：PCT/US2014/066524

    申请日：2014-11-20

    申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.

    发明人： BRAIDO, Peter N. ,  MCCARTHY, Andrea L. ,  SMITH, Kent J.

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2220/0008 ,  A61F2220/0075 ,  A61F2250/0023 ,  A61F2250/0069 ,  D05B1/12 ,  D05B1/14

    摘要： A prosthetic heart valve includes a collapsible and expandable stent having a proximal end, a distal end, an annulus section adjacent the proximal end and an aortic section adjacent the distal end, the stent including a plurality of struts. A cuff (500) may be coupled to the stent so that a flat, bottom edge of the cuff lies adjacent the proximal end of the stent. A pattern of stitches (P) may be circumferentially disposed around the flat bottom edge (524) of the cuff, the pattern of stitches alternating between stitches sewn to the cuff only and stitches sewn to both the cuff and the stent. The prosthetic heart valve may also comprise a the stent including a plurality of struts and a plurality of commissure features; a cuff coupled to the stent so that a top edge of the cuff lies adjacent the plurality of commissure features; and a plurality of tethers (Tl, T2) incorporated along the top edge of the cuff and coupled to the cuff only.

    摘要翻译： 假体心脏瓣膜包括可折叠和可扩张的支架，其具有近端，远端，邻近近端的环形部分和邻近远端的主动脉部分，支架包括多个支柱。 袖带（500）可以联接到支架，使得袖带的平坦的底部边缘邻近支架的近端。 线圈图案（P）可以围绕袖带的平底边缘（524）周向地设置，缝合图案仅在缝合到袖带的针脚和缝合到袖带和支架的缝合线之间交替。 假体心脏瓣膜还可以包括支架，其包括多个支柱和多个连合部件; 袖带，其联接到所述支架，使得所述袖带的顶边缘邻近所述多个连合特征; 以及沿着袖带的顶部边缘并入并仅与袖带相连的多个系绳（T1，T2）。

    LEAFLET IN CONFIGURATION FOR FUNCTION IN VARIOUS SHAPES AND SIZES
    5.
    发明申请
    LEAFLET IN CONFIGURATION FOR FUNCTION IN VARIOUS SHAPES AND SIZES 审中-公开
    各种形状和尺寸功能配置中的LEAFLET

    公开(公告)号：WO2014004793A2

    公开(公告)日：2014-01-03

    申请号：PCT/US2013/048132

    申请日：2013-06-27

    申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.

    发明人： BRAIDO, Peter N. ,  AHMANN, Katherine A. ,  FAHIM, Mina S. ,  ALLISON, Jeffrey J. ,  MCCARTHY, Andrea L.

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2220/005 ,  A61F2220/0066 ,  A61F2220/0075 ,  A61F2250/0017 ,  F04C2270/0421

    摘要： A prosthetic heart valve includes a collapsible and expandable stent having a proximal end, a distal end, an annulus section adjacent the proximal end and an aortic section adjacent the distal end. The heart valve further includes a plurality of commissure features disposed on the stent, and a collapsible and expandable valve assembly, the valve assembly including a plurality of leaflets connected to the plurality of commissure features, each of the plurality of leaflets having a free edge and being configured to have a tension line aligned near the free edge to prevent backflow.

    摘要翻译： 假体心脏瓣膜包括可折叠和可扩张的支架，其具有近端，远端，邻近近端的环形部分和与远端相邻的主动脉部分。 心脏瓣膜还包括设置在支架上的多个连合部件，以及可折叠和可膨胀的阀组件，所述阀组件包括连接到所述多个连合部件的多个传单，所述多个传单中的每一个均具有自由边缘， 被配置成具有在自由边缘附近对齐的张力线以防止回流。

    HEART VALVE REPAIR AND REPLACEMENT
    6.
    发明申请
    HEART VALVE REPAIR AND REPLACEMENT 审中-公开
    心瓣膜修复和更换

    公开(公告)号：WO2016201024A1

    公开(公告)日：2016-12-15

    申请号：PCT/US2016/036560

    申请日：2016-06-09

    申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.

    发明人： BRAIDO, Peter N. ,  FAHIM, Mina S. ,  BENSON, Thomas M. ,  DALE, Theodore P. ,  PARA, Andrea N. ,  KRANZ, Mark ,  GLIMSDALE, Mathias C.

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2409 ,  A61F2/2469 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2230/0006 ,  A61F2230/0069

    摘要： A prosthetic heart valve having an inflow end and an outflow end includes a collapsible and expandable stent having a plurality of commissure features, a plurality of first struts and a plurality of second struts. The plurality of first struts define a substantially cylindrical portion and the plurality of second struts have first ends attached to the cylindrical portion and free ends projecting radially outward from the cylindrical portion and configured to couple to adjacent heart tissue to anchor the stent. A collapsible and expandable valve assembly disposed within the stent has a plurality of leaflets coupled to the commissure features.

    摘要翻译： 具有流入端和流出端的假体心脏瓣膜包括具有多个连合特征的多个第一支柱和多个第二支柱的可收缩且可扩张的支架。 多个第一支柱限定基本上圆柱形的部分，并且多个第二支柱具有附接到圆柱形部分的第一端部和从圆柱形部分径向向外突出的自由端并且构造成联接到相邻的心脏组织以锚定支架。 设置在支架内的可折叠和可膨胀的阀组件具有耦合到连合件特征的多个传单。

    REDUCED PROFILE PROSTHETIC HEART VALVE
    8.
    发明申请
    REDUCED PROFILE PROSTHETIC HEART VALVE 审中-公开
    减少轮廓前置心脏瓣膜

    公开(公告)号：WO2015069683A1

    公开(公告)日：2015-05-14

    申请号：PCT/US2014/063995

    申请日：2014-11-05

    申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.

    发明人： BRAIDO, Peter N. ,  SMITH, Kent J.

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2409 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2250/0008 ,  A61F2250/0062

    摘要： A prosthetic heart valve (200) may include a stent (202) with a plurality of cells (212a-d) arranged in circumferential rows and a cuff (206) attached to the stent. A leaflet attachment panel (260) may be attached to and span a portion of one of the cells. A leaflet (208) having a belly (210) may be mounted to the leaflet attachment panel. The leaflet attachment panel may not be integral with the stent body. A reduced overlap area may be defined between a proximal end of the stent body and a proximalmost point of attachment of the leaflet belly to the cuff. The reduced overlap area may have a size dependent upon the circumferential row of cells the leaflet attachment panel is attached to and a position of the portion of the leaflet attachment panel to which the leaflet is mounted. Alternately, the leaflet may be attached directly to the stent.

    摘要翻译： 假体心脏瓣膜（200）可以包括具有排列成周向排的多个细胞（212a-d）的支架（202）和附接到支架的袖带（206）。 小叶连接面板（260）可以附接到并跨越其中一个单元的一部分。 具有腹部（210）的小叶（208）可以安装到小叶附着面板上。 小叶安装面板可能不与支架体一体。 可以在支架主体的近端和小叶腹部与袖带的最近点的附近点之间限定缩小的重叠区域。 减小的重叠区域可以具有取决于小叶附着面板附接到的圆周列的单元的大小和小叶安装面板的部分的位置。 或者，小叶可以直接附接到支架上。

    STENT DESIGNS FOR PROSTHETIC HEART VALVES
    9.
    发明申请
    STENT DESIGNS FOR PROSTHETIC HEART VALVES 审中-公开
    用于预防心脏瓣膜的STENT设计

    公开(公告)号：WO2015038458A1

    公开(公告)日：2015-03-19

    申请号：PCT/US2014/054485

    申请日：2014-09-08

    申请人： ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.

    发明人： BRAIDO, Peter N.

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2412 ,  A61F2210/0061 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2230/008 ,  A61F2250/0069

    摘要： A prosthetic heart valve includes a collapsible and expandable stent, a cuff attached to an annulus section of the stent, and leaflets attached to the cuff between a first location and a second location distal to the first location in a flow direction. The stent may include struts shaped to form a plurality of cells connected to one another in annular rows around the stent. The cuff may have top and bottom edges and may occupy a first group of the cells, such that cells above the top edge are open cells at least partially devoid of the cuff. The cuff may have a landing zone extending at least one-third of a length of the stent in the flow direction between the bottom edge of the cuff and a proximal end of a most proximal cell of the open cells when the stent is in an expanded use condition.

    摘要翻译： 假体心脏瓣膜包括可折叠和可扩张的支架，附接到支架的环空部分的袖带以及在流动方向上在第一位置和第二位置之间的第一位置和第二位置附接到袖带的小叶。 支架可以包括成形为形成多个细胞的支柱，所述多个细胞在支架周围以环形排彼此连接。 袖带可以具有顶部和底部边缘并且可以占据第一组细胞，使得顶部边缘上方的细胞是至少部分缺乏袖带的开放细胞。 袖带可以具有着陆区域，当支架处于扩张状态时，该覆盖区域在袖带的底部边缘与开放细胞的最近端的细胞的近端之间沿流动方向延伸至支架的长度的至少三分之一 使用条件。