公开(公告)号：WO2016028583A1

公开(公告)日：2016-02-25

申请号：PCT/US2015/044965

申请日：2015-08-13

Applicant: ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.

Inventor： BRAIDO, Peter N. ,  FAHIM, Mina S. ,  ANDERL, Steven F. ,  WHITE, Jason A. ,  ASHWORTH, Paul E. ,  LOW, Morgan ,  MOON, Loell B. ,  SAIKRISHNAN, Neelakantan

IPC: A61F2/24 ,  A61B17/00

CPC classification number: A61B5/6862 ,  A61B5/02 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/02158 ,  A61B5/026 ,  A61B5/6847 ,  A61B5/6858 ,  A61B17/0057 ,  A61B17/12122 ,  A61B2017/00022 ,  A61B2017/00575 ,  A61B2017/00632 ,  A61B2562/0247 ,  A61F2/24 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2445 ,  A61F2/2448 ,  A61F2/2472 ,  A61F2/844 ,  A61F2210/0066 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0008 ,  A61F2230/0034 ,  A61F2230/0065 ,  A61F2250/0002 ,  A61F2250/0004 ,  A61F2250/001 ,  A61F2250/0063 ,  A61F2250/0065

Abstract: Prosthetic heart devices may be implanted into the heart with a sensor (400) coupled to the device, the sensor being configured to measure physiological data, such as blood pressure, in the heart. Devices that may employ such sensors include prosthetic heart valves (100, 2000, 300, 4000) and occlusion devices (5000, 6000), although sensor systems may be deployed in the heart separate from other implantable devices. The sensors may include a body (402) with different configurations for attaching to the implantable device, such as apertures for sutures or fingers for connecting to structures of the implantable device. The sensors may provide data that allow a determination of aortic regurgitation or other information indicative of function of the implantable device and patient health during and after implantation of the device.

Abstract translation: 假体心脏装置可以用耦合到该装置的传感器（400）植入心脏中，该传感器被配置为测量心脏中的生理数据，例如血压。 可以使用这种传感器的装置包括假体心脏瓣膜（100,2000,300,4000）和闭塞装置（5000,6000），尽管传感器系统可以部署在与其它可植入装置分开的心脏中。 传感器可以包括具有不同构造的主体（402），用于连接到可植入装置，例如用于缝合线或手指的孔，用于连接到可植入装置的结构。 传感器可以提供数据，其允许在植入植入装置期间和之后确定主动脉瓣反流或指示可植入装置的功能的其他信息和患者健康。

公开(公告)号：WO2018160513A1

公开(公告)日：2018-09-07

申请号：PCT/US2018/019821

申请日：2018-02-27

Applicant: ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.

Inventor： ASHWORTH, Paul E.

IPC: A61K35/12

CPC classification number: G01N33/564 ,  A61K35/12 ,  G01N1/30 ,  G01N2001/305 ,  G01N2333/4716

Abstract: Methods of preparing a solid reference material so as to elicit a positive control response when tested for in-vitro complement activation include providing biological tissue; treating the tissue with an aqueous cellulose solution for a rime sufficient to allow fluid in the tissue to be replaced by the aqueous cellulose solution; drying the cellulose-treated tissue by a vacuum-drying process or a lyophilization process to form dried tissue; and storing the dried tissue in a dry, ambient environment. The tissue prepared by these methods and its use in an in-vitro complement assay and diagnostic kit are also described.

公开(公告)号：WO2017189941A1

公开(公告)日：2017-11-02

申请号：PCT/US2017/030011

申请日：2017-04-28

Applicant: ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.

Inventor： ASHWORTH, Paul E.

IPC: A01N1/00 ,  A01N1/02 ,  A61L27/36 ,  A61L31/04

CPC classification number: A61L27/3687 ,  A01N1/021 ,  A01N1/0231 ,  A61L27/3625 ,  A61L27/3691 ,  A61L31/042 ,  C08L1/00 ,  C08L1/26

Abstract: Methods of preparing biological tissue for bioprosthetic valves include providing fresh biological tissue; treating the tissue with an aqueous cellulose solution for a time sufficient to allow the fluid in the tissue to be replaced by the aqueous cellulose solution; and cross-linking the tissue, wherein the treating step is performed prior to, during, after, or both prior to and after the cross-linking step. The methods may include storing the cellulose-treated and cross-linked tissue in an aqueous solution; or drying the cellulose-treated and cross-linked tissue by a vacuum-drying or lyophilization process, and storing the dried tissue in a dry, ambient environment. The treated tissue may be in the form of a tissue component for a bioprosthetic valve, a valve assembly for a bioprosthetic valve or a fully assembled bioprosthetic valve incorporating the tissue.

Abstract translation: 制备用于生物假体瓣膜的生物组织的方法包括提供新鲜的生物组织; 用纤维素水溶液处理组织足够的时间以允许组织中的流体被纤维素水溶液置换; 和交联组织，其中处理步骤在交联步骤之前，之中，之后或之前和之后进行。 该方法可以包括将纤维素处理和交联的组织储存在水溶液中; 或通过真空干燥或冻干过程干燥经纤维素处理和交联的组织，并将干燥的组织储存在干燥的周围环境中。 处理过的组织可以是用于生物假体瓣膜的组织成分，用于生物瓣膜的瓣膜组件或包含组织的完全组装的生物瓣膜的形式。

公开(公告)号：WO2016028581A1

公开(公告)日：2016-02-25

申请号：PCT/US2015/044962

申请日：2015-08-13

Applicant: ST. JUDE MEDICAL, CARDIOLOGY DIVISION, INC.

Inventor： BRAIDO, Peter N. ,  FAHIM, Mina S. ,  MOON, Loell B. ,  ASHWORTH, Paul E. ,  SAIKRISHNAN, Neelakantan ,  ANDERL, Steven F.

IPC: A61F2/24

CPC classification number: A61F2/2472 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/02158 ,  A61B5/026 ,  A61B5/6847 ,  A61B5/6862 ,  A61B17/0057 ,  A61B17/12122 ,  A61B2017/00022 ,  A61B2017/00575 ,  A61B2017/00632 ,  A61B2562/0247 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2/2445 ,  A61F2/2448 ,  A61F2/844 ,  A61F2210/0066 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0008 ,  A61F2230/0034 ,  A61F2230/0065 ,  A61F2250/0002 ,  A61F2250/0004 ,  A61F2250/001 ,  A61F2250/0063 ,  A61F2250/0065

Abstract: A prosthetic device for implanting in a patient's heart includes (i) a therapeutic device capable of restoring function to a native heart valve; and (ii) at least one sensor including a body, an inductor coil disposed within the body, and a capacitor in communication with the inductor coil, the at least one sensor being coupled to the therapeutic device, and being configured to monitor proper function of the therapeutic device within the patient's heart.

Abstract translation: 用于植入患者心脏的假体装置包括（i）能够将功能恢复到天然心脏瓣膜的治疗装置; 和（ii）至少一个传感器，其包括主体，设置在所述主体内的电感线圈，以及与所述电感线圈连通的电容器，所述至少一个传感器耦合到所述治疗装置，并且被配置为监测所述至少一个传感器的适当功能 患者心脏内的治疗装置。