公开(公告)号：WO2021038540A1

公开(公告)日：2021-03-04

申请号：PCT/IB2020/058106

申请日：2020-08-31

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED

Inventor： RATHOD, Rajendrasinh Jashvantsinh ,  RAUT, Virendra Narendra ,  ΒΗΑΤΤ, Tushar Bhupendrabhai ,  SAVANT, Pratit Viram ,  JOSHI, Kiritkumar Parmeshkumar ,  JARAG, Tushar Mukund ,  CHIMANWALA, Sabbirhusen Yusufbhai ,  SENGUPTA, Prabal ,  KADIYALA, V.S.N. Murty ,  CHITTURI, Trinadha Rao

IPC: C07D487/04 ,  C07D473/34 ,  C07D239/48 ,  A61K31/505 ,  A61K31/519 ,  A61K31/522 ,  A61P35/00

Abstract: The present invention relates to novel cycloalkylidene carboxylic acids and derivatives thereof useful as Bruton tyrosine kinase (BTK) inhibitors. The present disclosure also relates to processes for their preparation, pharmaceutical compositions containing one or more such compounds, and to the use of such compounds and pharmaceutical compositions for the treatment of disorders involving mediation of BTK in humans (Formula I).

公开(公告)号：WO2021038540A

公开(公告)日：2021-03-04

申请号：PCT/IB2020/058106

申请日：2020-08-31

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED [IN]/[IN]

Inventor： RATHOD, Rajendrasinh Jashvantsinh ,  RAUT, Virendra Narendra ,  ΒΗΑΤΤ, Tushar Bhupendrabhai ,  SAVANT, Pratit Viram ,  JOSHI, Kiritkumar Parmeshkumar ,  JARAG, Tushar Mukund ,  CHIMANWALA, Sabbirhusen Yusufbhai ,  SENGUPTA, Prabal ,  KADIYALA, V.S.N. Murty ,  CHITTURI, Trinadha Rao

IPC: C07D487/04 ,  C07D473/34 ,  C07D239/48 ,  A61K31/505 ,  A61K31/519 ,  A61K31/522 ,  A61P35/00

Abstract: The present invention relates to novel cycloalkylidene carboxylic acids and derivatives thereof useful as Bruton tyrosine kinase (BTK) inhibitors. The present disclosure also relates to processes for their preparation, pharmaceutical compositions containing one or more such compounds, and to the use of such compounds and pharmaceutical compositions for the treatment of disorders involving mediation of BTK in humans (Formula I).

公开(公告)号：WO2018002958A1

公开(公告)日：2018-01-04

申请号：PCT/IN2017/050268

申请日：2017-06-30

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED

Inventor： KADIYALA, V.S.N. Murty ,  DESAI, Dipali Manubhai ,  RAUT, Virendra Narendra ,  SAVANT, Pratit Viram ,  JOSHI, Kiritkumar Parmeshkumar ,  CHAUDHARI, Umesh Vishnu ,  RATHOD, Rajendrasinh Jashvantsinh ,  BHATT, Tushar Bhupendrabhai ,  CHITTURI, Trinadha Rao

IPC: C07D487/04 ,  A61P35/00 ,  A61K31/519 ,  A61K31/52 ,  A61K31/522

Abstract: The present invention relates to novel hydrazide containing compounds as Bruton tyrosine kinase inhibitors, process of preparation thereof, and to the use of the compounds in the preparation of pharmaceutical compositions for the therapeutic treatment of disorders involving mediation of Bruton tyrosine kinase in humans.

Abstract translation: 本发明涉及作为布鲁顿酪氨酸激酶抑制剂的含有新型酰肼化合物，其制备方法，以及涉及这些化合物在制备用于治疗性治疗涉及调节 人类中的布鲁顿酪氨酸激酶。