公开(公告)号：WO2021038540A1

公开(公告)日：2021-03-04

申请号：PCT/IB2020/058106

申请日：2020-08-31

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED

Inventor： RATHOD, Rajendrasinh Jashvantsinh ,  RAUT, Virendra Narendra ,  ΒΗΑΤΤ, Tushar Bhupendrabhai ,  SAVANT, Pratit Viram ,  JOSHI, Kiritkumar Parmeshkumar ,  JARAG, Tushar Mukund ,  CHIMANWALA, Sabbirhusen Yusufbhai ,  SENGUPTA, Prabal ,  KADIYALA, V.S.N. Murty ,  CHITTURI, Trinadha Rao

IPC: C07D487/04 ,  C07D473/34 ,  C07D239/48 ,  A61K31/505 ,  A61K31/519 ,  A61K31/522 ,  A61P35/00

Abstract: The present invention relates to novel cycloalkylidene carboxylic acids and derivatives thereof useful as Bruton tyrosine kinase (BTK) inhibitors. The present disclosure also relates to processes for their preparation, pharmaceutical compositions containing one or more such compounds, and to the use of such compounds and pharmaceutical compositions for the treatment of disorders involving mediation of BTK in humans (Formula I).

公开(公告)号：WO2021074898A1

公开(公告)日：2021-04-22

申请号：PCT/IB2020/059785

申请日：2020-10-16

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED

Inventor： SHETH, Gaurav Sanjivkumar ,  CHIMANWALA, Sabbirhusen Yusufbhai ,  JARAG, Tushar Mukund ,  HAMPIHOLI, Aishwarya ,  MAITY, Saikat ,  SENGUPTA, Prabal ,  QURESHI, Gulamnizami Abdulsattar ,  CHAUDHARI, Umesh Vishnu ,  VENKAT, Raj Gopal ,  KADIYALA, V.s.n. Murty ,  KALAPATAPU, Sairam Vvm ,  JAIN, Vaibhav ,  CHITTURI, Trinadha Rao

IPC: C07D401/04 ,  C07D295/096 ,  A61K31/496 ,  A61K31/495 ,  A61P35/00

Abstract: The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.

公开(公告)号：WO2021038540A

公开(公告)日：2021-03-04

申请号：PCT/IB2020/058106

申请日：2020-08-31

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED [IN]/[IN]

Inventor： RATHOD, Rajendrasinh Jashvantsinh ,  RAUT, Virendra Narendra ,  ΒΗΑΤΤ, Tushar Bhupendrabhai ,  SAVANT, Pratit Viram ,  JOSHI, Kiritkumar Parmeshkumar ,  JARAG, Tushar Mukund ,  CHIMANWALA, Sabbirhusen Yusufbhai ,  SENGUPTA, Prabal ,  KADIYALA, V.S.N. Murty ,  CHITTURI, Trinadha Rao

IPC: C07D487/04 ,  C07D473/34 ,  C07D239/48 ,  A61K31/505 ,  A61K31/519 ,  A61K31/522 ,  A61P35/00

Abstract: The present invention relates to novel cycloalkylidene carboxylic acids and derivatives thereof useful as Bruton tyrosine kinase (BTK) inhibitors. The present disclosure also relates to processes for their preparation, pharmaceutical compositions containing one or more such compounds, and to the use of such compounds and pharmaceutical compositions for the treatment of disorders involving mediation of BTK in humans (Formula I).

公开(公告)号：WO2017168454A3

公开(公告)日：2017-10-05

申请号：PCT/IN2017/050127

申请日：2017-04-03

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED

Inventor： SENGUPTA, Prabal ,  KADIYALA, V.S.N. Murty ,  DESAI, Dipali Manubhai ,  CHIMANWALA, Sabbirhusen Yusufbhai ,  JARAG, Tushar Mukund ,  SHETH, Gaurav Sanjivkumar ,  CHITTURI, Trinadha Rao

IPC: C07D417/12

Abstract: The present invention relates to novel compounds of Formula I as Bruton tyrosine kinase inhibitors, process of preparation thereof, and to the use of the compounds in the preparation of pharmaceutical compositions for the therapeutic treatment of disorders involving mediation of Bruton tyrosine kinase in humans.

公开(公告)号：WO2017168454A2

公开(公告)日：2017-10-05

申请号：PCT/IN2017/050127

申请日：2017-04-03

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED

Inventor： SENGUPTA, Prabal ,  KADIYALA, V.S.N. Murty ,  DESAI, Dipali Manubhai ,  CHIMANWALA, Sabbirhusen Yusufbhai ,  JARAG, Tushar Mukund ,  SHETH, Gaurav Sanjivkumar ,  CHITTURI, Trinadha Rao

CPC classification number: C07D417/12 ,  C07D417/14

Abstract: The present invention relates to novel compounds of Formula I as Bruton tyrosine kinase inhibitors, process of preparation thereof, and to the use of the compounds in the preparation 5 of pharmaceutical compositions for the therapeutic treatment of disorders involving mediation of Bruton tyrosine kinase in humans.

Abstract translation: 本发明涉及作为布鲁顿酪氨酸激酶抑制剂的式I的新化合物，其制备方法，以及涉及所述化合物在用于治疗性治疗涉及病症的药物组合物的制备5中的用途 Bruton酪氨酸激酶在人体内的介导。