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公开(公告)号：WO2017134685A2
公开(公告)日：2017-08-10
申请号：PCT/IN2017/050048
申请日：2017-02-02
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED
Inventor： KADIYALA, V.S.N. Murty , RAUT, Virendra Narendra , SAVANT, Pratit , SHETH, Chetana Kaushal , CHAUDHARI, Umesh Vishnu , RATHOD, Rajendrasinh Jashvantsinh , BHATT, Tushar Bhupendrabhai , CHITTURI, Trinadha Rao
IPC: C07D487/02
CPC classification number: C07D487/04
Abstract: The present invention relates to novel hydrazino compounds of Formula (I) as Bruton tyrosine kinase inhibitors, process of preparation thereof, and to the use of the compounds in the preparation of pharmaceutical compositions for the therapeutic treatment of disorders involving mediation of Bruton tyrosine kinase in humans.
Abstract translation: 本发明涉及作为布鲁顿酪氨酸激酶抑制剂的式（I）的新型肼基化合物，其制备方法以及该化合物在制备用于治疗 涉及人体中布鲁顿酪氨酸激酶介导的疾病。
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公开(公告)号：WO2021074898A1
公开(公告)日：2021-04-22
申请号：PCT/IB2020/059785
申请日：2020-10-16
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED
Inventor： SHETH, Gaurav Sanjivkumar , CHIMANWALA, Sabbirhusen Yusufbhai , JARAG, Tushar Mukund , HAMPIHOLI, Aishwarya , MAITY, Saikat , SENGUPTA, Prabal , QURESHI, Gulamnizami Abdulsattar , CHAUDHARI, Umesh Vishnu , VENKAT, Raj Gopal , KADIYALA, V.s.n. Murty , KALAPATAPU, Sairam Vvm , JAIN, Vaibhav , CHITTURI, Trinadha Rao
IPC: C07D401/04 , C07D295/096 , A61K31/496 , A61K31/495 , A61P35/00
Abstract: The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.
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公开(公告)号：WO2018002958A1
公开(公告)日：2018-01-04
申请号：PCT/IN2017/050268
申请日：2017-06-30
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED
Inventor： KADIYALA, V.S.N. Murty , DESAI, Dipali Manubhai , RAUT, Virendra Narendra , SAVANT, Pratit Viram , JOSHI, Kiritkumar Parmeshkumar , CHAUDHARI, Umesh Vishnu , RATHOD, Rajendrasinh Jashvantsinh , BHATT, Tushar Bhupendrabhai , CHITTURI, Trinadha Rao
IPC: C07D487/04 , A61P35/00 , A61K31/519 , A61K31/52 , A61K31/522
Abstract: The present invention relates to novel hydrazide containing compounds as Bruton tyrosine kinase inhibitors, process of preparation thereof, and to the use of the compounds in the preparation of pharmaceutical compositions for the therapeutic treatment of disorders involving mediation of Bruton tyrosine kinase in humans.
Abstract translation: 本发明涉及作为布鲁顿酪氨酸激酶抑制剂的含有新型酰肼化合物，其制备方法，以及涉及这些化合物在制备用于治疗性治疗涉及调节 人类中的布鲁顿酪氨酸激酶。
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公开(公告)号：WO2017134685A3
公开(公告)日：2017-08-10
申请号：PCT/IN2017/050048
申请日：2017-02-02
Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED
Inventor： KADIYALA, V.S.N. Murty , RAUT, Virendra Narendra , SAVANT, Pratit , SHETH, Chetana Kaushal , CHAUDHARI, Umesh Vishnu , RATHOD, Rajendrasinh Jashvantsinh , BHATT, Tushar Bhupendrabhai , CHITTURI, Trinadha Rao
IPC: C07D487/02
Abstract: The present invention relates to novel hydrazino compounds of Formula (I) as Bruton tyrosine kinase inhibitors, process of preparation thereof, and to the use of the compounds in the preparation of pharmaceutical compositions for the therapeutic treatment of disorders involving mediation of Bruton tyrosine kinase in humans.
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