公开(公告)号：WO2021074898A1

公开(公告)日：2021-04-22

申请号：PCT/IB2020/059785

申请日：2020-10-16

Applicant: SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED

Inventor： SHETH, Gaurav Sanjivkumar ,  CHIMANWALA, Sabbirhusen Yusufbhai ,  JARAG, Tushar Mukund ,  HAMPIHOLI, Aishwarya ,  MAITY, Saikat ,  SENGUPTA, Prabal ,  QURESHI, Gulamnizami Abdulsattar ,  CHAUDHARI, Umesh Vishnu ,  VENKAT, Raj Gopal ,  KADIYALA, V.s.n. Murty ,  KALAPATAPU, Sairam Vvm ,  JAIN, Vaibhav ,  CHITTURI, Trinadha Rao

IPC: C07D401/04 ,  C07D295/096 ,  A61K31/496 ,  A61K31/495 ,  A61P35/00

Abstract: The present invention relates to novel compounds useful as malic enzyme (ME) inhibitors, processes for their preparation and use of these compounds for the therapeutic treatment of disorders mediated by ME such as cancers (e.g. pancreatic ductal adenocarcinoma (PDAC)) in humans.