公开(公告)号：WO2013142758A1

公开(公告)日：2013-09-26

申请号：PCT/US2013/033429

申请日：2013-03-22

Applicant: SURMODICS, INC. ,  OPPERMAN, Gary ,  NELSON, Wendy

Inventor： OPPERMAN, Gary ,  NELSON, Wendy

IPC: C12Q1/28 ,  G01N33/52 ,  G01N33/535 ,  G01N33/558 ,  G01N33/58

CPC classification number: G01N33/581 ,  C12Q1/28 ,  G01N21/78 ,  G01N33/52 ,  G01N33/535 ,  G01N33/558

Abstract: The invention provides compositions, kits, and methods for performing colorimetric analysis. A substrate is reacted to generate a chromogenic reaction product, and a reaction stop reagent that is a sulfonic acid is added to stop and stabilize the reaction product. The absorbance properties of the chromogenic reaction product can be maintained over significantly longer periods of time of that of conventional reagents and methods. The sulfonic acid can be used in assays such as ELISAs in order to provide a more accurate and safer detection of analytes in a biological sample.

Abstract translation: 本发明提供用于进行比色分析的组合物，试剂盒和方法。 使底物反应生成显色反应产物，并加入作为磺酸的反应停止试剂以停止并稳定反应产物。 显色反应产物的吸光度特性可以在常规试剂和方法的显着更长的时间内保持。 磺酸可用于诸如ELISA的测定中，以便提供对生物样品中分析物的更准确和更安全的检测。

公开(公告)号：WO2007012050A2

公开(公告)日：2007-01-25

申请号：PCT/US2006/028252

申请日：2006-07-20

Applicant: SURMODICS, INC. ,  DONALDSON COMPANY, INC. ,  LODHI, Muhammad ,  NAQVI, Tahmina ,  OPPERMAN, Gary ,  CHUNG, Hoo, Young ,  SCHINDLER, Melvin, S.

Inventor： LODHI, Muhammad ,  NAQVI, Tahmina ,  OPPERMAN, Gary ,  CHUNG, Hoo, Young ,  SCHINDLER, Melvin, S.

IPC: C12M3/06

CPC classification number: C12N5/0075 ,  A61L27/38 ,  C12M23/20 ,  C12M25/14 ,  C12N2533/30

Abstract: The invention provides cell-adherent polymeric coatings for articles having a nanofibrillar structure. The coatings include a synthetic, non-biodegradable polymer having at least one pendent amine group, wherein the polymer is covalently immobilized on the article via latent reactive groups. The invention also provides methods for the long term culturing of cells using the polymer coated nanofibrillar structures. The polymer coated nanofibrillar structures of the invention have been found to be particularly useful for the growth and differentiation of cells, including neural precursors.

Abstract translation: 本发明提供用于具有纳米纤丝结构的制品的细胞粘附聚合物涂层。 该涂层包括具有至少一个侧胺基团的合成的，不可生物降解的聚合物，其中聚合物通过潜在反应性基团共价固定在制品上。 本发明还提供了使用聚合物包被的纳米纤丝结构长期培养细胞的方法。 已经发现本发明的聚合物涂覆的纳米纤丝结构对于细胞（包括神经前体）的生长和分化特别有用。

公开(公告)号：WO2007056338A2

公开(公告)日：2007-05-18

申请号：PCT/US2006/043283

申请日：2006-11-08

Applicant: SURMODICS, INC. ,  OPPERMAN, Gary

Inventor： OPPERMAN, Gary

IPC: B05D5/04 ,  B05D3/06 ,  C09D5/00 ,  A61L27/34 ,  A61L31/10 ,  A61L29/08 ,  C08J7/04

CPC classification number: A61L29/085 ,  A61L27/34 ,  A61L31/10 ,  A61L2420/02 ,  B01D67/0088 ,  B01D67/0093 ,  B01D71/36 ,  B01D2323/02 ,  B01D2323/345 ,  B01D2323/38 ,  B01D2325/04 ,  B05D1/18 ,  B05D3/061 ,  B05D7/02 ,  B82Y30/00 ,  Y10T428/24322 ,  Y10T428/249953 ,  Y10T428/26 ,  Y10T428/265 ,  Y10T428/31725 ,  Y10T428/31855

Abstract: The invention provides methods for forming ultra-thin hydrophilic polymeric coatings on articles, as well as articles formed therefrom. The coatings are formed by irradiating a composition including a polymer having pendent photoreactive groups while the composition is in contact with a surface of the article.

Abstract translation: 本发明提供了在物品上形成超薄亲水性聚合物涂层以及由其形成的制品的方法。 通过在组合物与制品的表面接触的同时照射包含具有侧基光反应性基团的聚合物的组合物来形成涂层。

公开(公告)号：WO2007012051A1

公开(公告)日：2007-01-25

申请号：PCT/US2006/028253

申请日：2006-07-20

Applicant: SURMODICS, INC. ,  LODHI, Muhammad ,  NAQVI, Tahmina ,  OPPERMAN, Gary

Inventor： LODHI, Muhammad ,  NAQVI, Tahmina ,  OPPERMAN, Gary

IPC: A61L27/38 ,  A61L27/40 ,  A61L27/34 ,  A61L31/10 ,  A61L31/12

CPC classification number: A61L27/34 ,  A61L27/38 ,  A61L27/40 ,  A61L31/10 ,  A61L31/12 ,  C08L39/02 ,  C08L33/10 ,  C08L101/02 ,  C08L33/08

Abstract: The invention provides cell-adherent polymeric coatings for articles, the coating including a synthetic, non-biodegradable polymer having a plurality of pendent amine groups, wherein the polymer is covalently immobilized on the article via latent reactive groups. The invention also provides methods for the long-term attachment of cells using the polymeric coatings.

Abstract translation: 本发明提供用于制品的细胞粘附聚合物涂层，该涂层包括具有多个侧挂胺基团的合成的，不可生物降解的聚合物，其中聚合物通过潜在的反应性基团共价固定在制品上。 本发明还提供了使用聚合物涂层长期附着细胞的方法。

公开(公告)号：WO2016115361A1

公开(公告)日：2016-07-21

申请号：PCT/US2016/013430

申请日：2016-01-14

Applicant: SURMODICS, INC.

Inventor： JELLE, Bruce ,  SLAGER, Joram ,  MCGONIGLE, Joseph S. ,  MURPHY, Rick ,  BACH, Andrew G. ,  WOODWICK SIDES, Teryl L, ,  ANGAMUTHU, Ambereen ,  LUNDQUIST, Sean ,  OPPERMAN, Gary ,  LOCKWOOD, Nathan A.

IPC: A61M25/10

CPC classification number: A61F2/2433 ,  A61M25/0102 ,  A61M25/0668 ,  A61M25/09041 ,  A61M25/10 ,  A61M2025/0681 ,  A61M2025/1081

Abstract: The disclosure provides insertion tools and articles that facilitate entry of a medical device, such as a balloon catheter, into the body. In embodiments the insertion tools have an elongate hollow body (50) that is able to protect a portion of a medical device, such as a balloon of a balloon catheter, during an insertion procedure. In one embodiment the insertion tool has an elongate hollow body (131), a tapered distal end (135), and a locking mechanism (133) at the proximal end which can secure a portion of a balloon catheter. An opening at the distal end can allow passage of the balloon in a folded uninflated state.

Abstract translation: 本公开提供了便于将诸如气囊导管的医疗装置进入体内的插入工具和物品。 在实施例中，插入工具具有细长的中空本体（50），其能够在插入过程期间保护医疗装置的一部分，例如球囊导管的球囊。 在一个实施例中，插入工具具有细长的中空本体（131），锥形远端（135）和在近端处的可固定球囊导管的一部分的锁定机构（133）。 在远端处的开口可以允许球囊在折叠的未膨胀状态下通过。

公开(公告)号：WO2016022796A1

公开(公告)日：2016-02-11

申请号：PCT/US2015/044002

申请日：2015-08-06

Applicant: SURMODICS, INC.

Inventor： BABCOCK, David E. ,  LUNDQUIST, Sean ,  OPPERMAN, Gary ,  TORGUSON, Adriyn ,  JENTZ, Tim

IPC: A61L27/34 ,  A61L29/06 ,  A61L29/08 ,  A61K31/7024 ,  C08L29/04

CPC classification number: A61L27/34 ,  A61K31/7024 ,  A61L29/06 ,  A61L29/085

Abstract: Embodiments of the disclosure include coatings comprising an oligomerized polyphenol layer. The oligomerized polyphenol layer can be used as an intermediate coated layer on a medical device that hydrogen bonds to a synthetic or natural polymer, which in turn can be used as a top coat or further associated with another coated layer. The multilayered coatings can provide properties such as hemocompatibility or lubricity. In other embodiments, the oligomerized polyphenol layer is used on a medical device as a hemostatic layer configured to contact blood and promote coagulation. The oligomerized polyphenol layer can also be used on the inner surface (e.g., inner diameter) of a medical device to prevent bacterial adherence. The oligomerized polyphenol layer can also be used on the surface of a in vitro diagnostic article, or a cell culture device to, promote adsorption of a biological molecule.

Abstract translation: 本公开的实施方案包括包含低聚多酚层的涂层。 低聚多酚层可以用作医疗装置上的中间涂层，氢层与合成或天然聚合物键合，其又可以用作顶涂层，或进一步与另一涂层相连。 多层涂层可以提供诸如血液相容性或润滑性的性质。 在其它实施方案中，低聚多酚层用作医疗装置，作为构造成接触血液并促进凝血的止血层。 低聚多酚层也可用于医疗装置的内表面（例如内径），以防细菌粘附。 低聚多酚层也可用于体外诊断制品或细胞培养装置的表面，以促进生物分子的吸附。