公开(公告)号：WO2021123126A1

公开(公告)日：2021-06-24

申请号：PCT/EP2020/086972

申请日：2020-12-18

Applicant: TECHNISCHE UNIVERSITAET MUENCHEN

Inventor： LIELEG, Oliver ,  KIMNA, Ceren ,  WINKELJANN, Benjamin

IPC: A61L27/34 ,  A61L27/54 ,  A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L27/50 ,  A61L29/14 ,  A61L31/14 ,  A61L2300/406 ,  A61L2300/602 ,  A61L2300/62 ,  A61L2420/02 ,  A61L29/085

Abstract: The present invention relates to a method for preparation of a functionalized surface comprising the steps: a) coating of a carrier with a least one polymer selected from a polyanionic or polycationic polymer, b) addition of at least one compound to the coated carrier of step a), c) exposing the at least one polyanionic or polycationic polymer on the coated carrier of step b) to an organic solvent, resulting in compaction of the at least one polyanionic or polycationic polymer and thereby encapsulating the at least one compound, d) reversible cross-linking of the at least one polyanionic or polycationic polymer of step c) with at least one cross-linker; e) removal of the organic solvent. Furthermore, the invention relates to a functionalized surface, a functionalized surface for use in medicine and a method for releasing a compound ex vivo.