公开(公告)号：WO2013011368A9

公开(公告)日：2013-03-21

申请号：PCT/IB2012001400

申请日：2012-07-18

Applicant: TEVA PHARMA ,  AHARONI AMIR ,  ZARETZKY MARIANNA

Inventor： AHARONI AMIR ,  ZARETZKY MARIANNA

IPC: C12P21/06

CPC classification number: C07K14/7155 ,  A61K38/00 ,  A61K38/1793 ,  A61K38/2006 ,  A61K45/06 ,  C07K14/54 ,  A61K2300/00

Abstract: Provided are engineered soluble hIL-17RA receptors with high affinity to hIL-17 that inhibit downstream IL17A induced signaling events in cells. Also provided are methods of inhibiting hIL-17A induced secretion of CXCL1 and/or IL-6 in cells, as well as methods of treating inflammation and/or inflammatory disorders in a subject.

Abstract translation: 提供与hIL-17高亲和力的工程化可溶性hIL-17RA受体，其抑制细胞中下游IL17A诱导的信号传导事件。 还提供了抑制细胞中hIL-17A诱导的CXCL1和/或IL-6分泌的方法，以及治疗受试者的炎症和/或炎性病症的方法。

公开(公告)号：WO2005049787A3

公开(公告)日：2006-05-26

申请号：PCT/IL2004001079

申请日：2004-11-24

Applicant: YEDA RES & DEV ,  YISSUM RES DEV CO ,  MEDICAL RES COUNCIL ,  TAWFIK DAN ,  BERNATH KALIA ,  AHARONI AMIR ,  PEISAJOVICH SERGIO ,  GRIFFITHS ANDREW D ,  MASTROBATTISTA ENRICO ,  MAGDASSI SHLOMO

Inventor： TAWFIK DAN ,  BERNATH KALIA ,  AHARONI AMIR ,  PEISAJOVICH SERGIO ,  GRIFFITHS ANDREW D ,  MASTROBATTISTA ENRICO ,  MAGDASSI SHLOMO

IPC: C12N20060101 ,  C12N15/10 ,  C40B40/08

CPC classification number: C12N15/1075 ,  C40B40/08

Abstract: The present invention provides an in vitro system for compartmentalization of molecular or cellular libraries and provides methods for selection and isolation of desired molecules or cells from the libraries. The library includes a plurality of distinct molecules or cells encapsulated within a water-in-oil-in-water emulsion. The emulation includes a continuous external aqueous phase and a discontinuous dispersion of water-in-oil droplets. The internal aqueous phase of a plurality of such droplets comprises a specific molecule or cell that is within the plurality of distinct molecules or cells of the library.

Abstract translation: 本发明提供了用于分子或细胞文库区分的体外系统，并提供从文库中选择和分离所需分子或细胞的方法。 该文库包括多个不同的分子或包封在水包油包水乳液中的细胞。 仿真包括连续的外部水相和油包水滴的不连续分散体。 多个这样的液滴的内部水相包含位于文库的多个不同分子或细胞内的特定分子或细胞。

公开(公告)号：WO2004078991A3

公开(公告)日：2006-01-05

申请号：PCT/IL2004000216

申请日：2004-03-04

Applicant: YEDA RES & DEV ,  TAWFIK DAN S ,  AHARONI AMIR ,  GAYDUKOV LEONID ,  SUSSMAN JOEL L ,  SILMAN ISRAEL

Inventor： TAWFIK DAN S ,  AHARONI AMIR ,  GAYDUKOV LEONID ,  SUSSMAN JOEL L ,  SILMAN ISRAEL

IPC: C12N9/16 ,  C12Q20060101 ,  C12Q1/00 ,  C07H21/04

CPC classification number: C12N9/18 ,  A61K38/00 ,  C12N9/16

Abstract: Isolated polynucleotides and polypeptides encoded therefrom are provided. These include mutated PON enzymes with increased, modified or substantially the same substrate specificity as compared to respective wild-type PON. Also provided are kits and methods using these enzymes.

Abstract translation: 提供了分离的多核苷酸及其编码的多肽。 这些包括与相应的野生型PON相比具有增加的，修饰的或基本上相同的底物特异性的突变的PON酶。 还提供了使用这些酶的试剂盒和方法。

公开(公告)号：WO2005049787A9

公开(公告)日：2005-06-23

申请号：PCT/IL2004001079

申请日：2004-11-24

Applicant: YEDA RES & DEV ,  YISSUM RES DEV CO ,  MEDICAL RES COUNCIL ,  TAWFIK DAN ,  BERNATH KALIA ,  AHARONI AMIR ,  PEISAJOVICH SERGIO ,  GRIFFITHS ANDREW D ,  MASTROBATTISTA ENRICO ,  MAGDASSI SHLOMO

Inventor： TAWFIK DAN ,  BERNATH KALIA ,  AHARONI AMIR ,  PEISAJOVICH SERGIO ,  GRIFFITHS ANDREW D ,  MASTROBATTISTA ENRICO ,  MAGDASSI SHLOMO

IPC: A61K9/66 ,  C12N20060101 ,  C12N9/96 ,  C12N15/10 ,  C12Q1/68 ,  C40B40/08 ,  G01N33/536 ,  C12N

CPC classification number: C12N15/1075 ,  C40B40/08

Abstract: The present invention provides an in vitro system for compartmentalization of molecular or cellular libraries and provides methods for selection and isolation of desired molecules or cells from the libraries. The library includes a plurality of distinct molecules or cells encapsulated within a water-in-oil-in-water emulsion. The emulation includes a continuous external aqueous phase and a discontinuous dispersion of water-in-oil droplets. The internal aqueous phase of a plurality of such droplets comprises a specific molecule or cell that is within the plurality of distinct molecules or cells of the library.

Abstract translation: 本发明提供了用于分子或细胞文库区分的体外系统，并提供从文库中选择和分离所需分子或细胞的方法。 该文库包括多个不同的分子或包封在水包油包水乳液中的细胞。 仿真包括连续的外部水相和油包水滴的不连续分散体。 多个这样的液滴的内部水相包含位于文库的多个不同分子或细胞内的特定分子或细胞。