公开(公告)号：WO2018028371A1

公开(公告)日：2018-02-15

申请号：PCT/CN2017/092393

申请日：2017-07-10

Applicant: THE CHINESE UNIVERSITY OF HONG KONG

Inventor： CHAN, Michael ,  LEE, Marianne ,  HEATER, Bradley

IPC: C07K19/00 ,  C12N15/62 ,  C12N15/63 ,  C07K14/32

CPC classification number: C07K14/325 ,  C07K19/00 ,  C12N9/14 ,  C12N9/20 ,  C12N9/2402 ,  C12N9/48 ,  C12N9/93 ,  C12N9/96 ,  C12N11/02 ,  C12N15/62 ,  C12P7/64

Abstract: It provides novel fusion proteins that are capable of self-crystallization and exhibit improved physical properties such as enhanced tolerance to organic solvents and increased thermostability. Polynucleotides encoding the fusion proteins as well as methods of making and using such fusion proteins are also described.

Abstract translation: 它提供了能够自结晶并且表现出改进的物理性质如增强的对有机溶剂的耐受性和增加的热稳定性的新型融合蛋白。 还描述了编码融合蛋白的多核苷酸以及制备和使用这种融合蛋白的方法。

公开(公告)号：WO2020211782A1

公开(公告)日：2020-10-22

申请号：PCT/CN2020/084939

申请日：2020-04-15

Applicant: THE CHINESE UNIVERSITY OF HONG KONG

Inventor： CHAN, Michael ,  LEE, Marianne ,  YANG, Zaofeng

IPC: C07K14/325 ,  C12N15/32 ,  A61K47/66

Abstract: Provided are novel recombinant proteins that are capable of self-crystallization and exhibit desirable physical properties such as enhanced cellular uptake or and endoso-mal escape. Polynucleotides encoding the recombinant proteins as well as methods of making and using such proteins are also described.