公开(公告)号：WO2004017821A2

公开(公告)日：2004-03-04

申请号：PCT/US2003/026492

申请日：2003-08-25

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： KUBAN, Barry, D. ,  KLINGENSMITH, Jon, D. ,  VINCE, D., Geoffrey ,  NAIR, Anuja

IPC: A61B

CPC classification number: A61B8/4461 ,  A61B5/02007 ,  A61B5/0456 ,  A61B8/0833 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4488 ,  A61B8/483 ,  A61B8/543 ,  G06T7/0012 ,  G06T7/12 ,  G06T2207/10132 ,  G06T2207/30048 ,  G06T2207/30101

Abstract: A system and method is provided for substantially synchronizing the acquisition of blood-vessel data to an identifiable portion of heartbeat data. Specifically, a data-gathering device is adapted to acquire heartbeat data and blood-vessel data from a heart-monitoring device and a data-gathering probe, respectively. In a preferred embodiment of the present invention, the blood-vessel data is acquired during a cyclical portion of the heartbeat data. By identifying a cyclical (or commonly reoccurring) portion of the heartbeat data and acquiring blood-vessel data during this cyclical portion (or during an interval that substantially corresponds thereto), the blood vessel can be analyzed as if it were standing still -- i.e., not expanding and relaxing. In one embodiment of the present invention, the heart-monitoring device includes an EKG device, the data-gathering device includes an intra-vascular ultrasound (IVUS) device and a computing device, and the data-gathering probe includes at least one transducer. In another embodiment of the present invention, the data-gathering system further includes a retraction device adapted to move the data-gathering probe though a blood vessel at a substantially steady speed.

Abstract translation: 提供了一种用于将血管数据的获取基本上同步到心跳数据的可识别部分的系统和方法。 具体地，数据收集装置适于分别从心脏监测装置和数据收集探针获取心跳数据和血管数据。 在本发明的优选实施例中，在心跳数据的周期部分期间获取血管数据。 通过在该循环部分（或在与其基本对应的间隔期间）识别心跳数据的周期性（或通常重复发生）部分并获取血管数据，可以分析血管，如同静置时一样 - 即 ，不扩大和放松。 在本发明的一个实施例中，所述心脏监测装置包括EKG装置，所述数据收集装置包括血管内超声（IVUS）装置和计算装置，并且所述数据收集探针包括至少一个换能器。 在本发明的另一个实施例中，数据收集系统还包括一个缩回装置，其适于以基本上稳定的速度移动通过血管的数据收集探针。

公开(公告)号：WO2007047566A3

公开(公告)日：2007-04-26

申请号：PCT/US2006/040334

申请日：2006-10-14

Applicant: THE CLEVELAND CLINIC FOUNDATION ,  NAIR, Anuja ,  KUBAN, Barry, D. ,  VINCE, D., Geoffrey ,  KLINGENSMITH, Jon, David

Inventor： NAIR, Anuja ,  KUBAN, Barry, D. ,  VINCE, D., Geoffrey ,  KLINGENSMITH, Jon, David

IPC: A61B8/14

Abstract: A system and method is provided for using ultrasound data backscattered from vascular tissue to estimate the transfer function of a catheter. In one embodiment of the present invention, a computing device is electrically connected to a catheter and used to acquire R backscattered data from a vascular structure. The backscattered ultrasound data is then used with an algorithm to estimate transfer function(s) which is used to calculate response data for the vascular tissue. In another embodiment, an IVUS console is electrically connected to a catheter and a computing device is used to acquire backscattered data from a vascular structure. The backscattered data is then transmitted to the computing device, where it is used to estimate the catheter's transfer function and to calculate response data for the vascular tissue. The response data and the histology data are then used to characterize at least a portion of the vascular tissue.

公开(公告)号：WO2004017823A3

公开(公告)日：2004-03-04

申请号：PCT/US2003/027075

申请日：2003-08-26

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： KLINGENSMITH, Jon, D. ,  VINCE, Geoffrey, D. ,  NAIR, Anuja ,  KUBAN, Barry, D.

IPC: A61B8/12

Abstract: A system and method is provided for using a first vascular (20) image, or more particularly a plurality of control points (22) located thereon, to identify a border (64) on a second vascular image. Embodiments of the present invention operate in accordance with an intra-vascular ultrasound (IVUS) device and a computing device electrically connected thereto. Specifically, in one embodiment of the present invention, an IVUS console is electrically connected to a computing device and adapted to acquire IVUS data. The IVUS data (or multiple sets thereof) is then provided to (or acquired by) the computing device (120). In one embodiment of the present invention, the computing device includes a plurality of applications operating thereon -- i.e., a border-detection application (122), an extrapolation application (124), and an active-contour application (126). These applications are used to (i) identify a border and control points on a first IVUS image (i.e., any IVUS image), (ii) extrapolate the control points to a second IVUS image (i.e., another IVUS image), (iii) identify a border on the second IVUS image, and (iv) adjust the border on the second IVUS image in accordance with at least one factor. In one embodiment of the present invention, the at least one factor is selected from a group consisting of gradient factor, continuity factor, and curvature factor.

公开(公告)号：WO2013123190A1

公开(公告)日：2013-08-22

申请号：PCT/US2013/026140

申请日：2013-02-14

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： KUBAN, Barry, D. ,  ROIZEN, Michael, F.

IPC: G06F19/00 ,  G06Q10/00

CPC classification number: G06Q10/063 ,  G06F19/00 ,  G06F19/328 ,  G06F19/3481 ,  G06Q50/22 ,  G16H40/63 ,  G16H50/70

Abstract: A method includes determining team participant members for one or more wellness teams. The method includes aggregating participant medical data for each of the one or more wellness teams from one or more networked physiologic stations configured to receive the medical data. The method includes analyzing the medical data to determine wellness information for the one or more wellness teams associated with the aggregated participant medical data. The method can be operated on a system where the system includes at least one physiologic station to generate participant medical information from a plurality of participants. This can include an identification component to facilitate trust in collected data. A storage medium collects the medical information over a network from the plurality of participants and an analyzer determines group wellness information from the collected medical information.

Abstract translation: 一种方法包括确定一个或多个健康团队的团队参与者成员。 该方法包括从被配置为接收医疗数据的一个或多个联网生理站点聚集一个或多个健康团队中的每一个的参与者医疗数据。 该方法包括分析医疗数据以确定与聚合的参与者医疗数据相关联的一个或多个健康团队的健康信息。 该方法可以在系统上操作，其中系统包括至少一个生理站以从多个参与者产生参与者医疗信息。 这可以包括识别组件以便于收集数据的信任。 存储介质通过网络从多个参与者收集医疗信息，并且分析器从所收集的医疗信息中确定组健康信息。

公开(公告)号：WO2005091885A3

公开(公告)日：2005-10-06

申请号：PCT/US2005/006159

申请日：2005-02-25

Applicant: THE CLEVELAND CLINIC FOUNDATION ,  KLINGENSMITH, Jon, D. ,  NAIR, Anuja ,  KUBAN, Barry, D. ,  VINCE, D., Geoffrey

Inventor： KLINGENSMITH, Jon, D. ,  NAIR, Anuja ,  KUBAN, Barry, D. ,  VINCE, D., Geoffrey

IPC: A61B18/04 ,  A61B8/00 ,  A61B6/00 ,  A61B5/05

Abstract: A system and method is provided for using the frequency spectrum of a radio frequency (RF) signal backscattered from vascular tissue to identify at least one border ( e.g. , tissue interface, etc.) on a vascular image. Embodiments of the present invention operate in accordance with a data gathering device ( e.g. , an intra-vascular ultrasound (IVUS) device, etc.) electrically connected to a computing device and a transducer via a catheter. The transducer is used to gather radio frequency (RF) data backscattered from vascular tissue. The RF data is then provided to (or acquired by) the computing device via the data-gathering device. In one embodiment of the present invention, the computing device includes (i) at least one data storage device ( e.g. , database, memory, etc.) for storing a plurality of tissue types and parameters related thereto and (ii) at least one application ( e.g. , a characterization application, a gradient-border application, a frequency-border application and/or an active-contour application). The characterization application is used to convert (or transform) the RF data into the frequency domain and to identify a plurality of parameters associated therewith. The identified parameters are then compared to the parameters stored in the data storage device to identify the corresponding tissue type. This information ( e.g. , tissue type, corresponding RF data, etc.) is then used, either alone or together with other border-related information ( e.g. , gradient information, other-border information, etc.), to determine at least one border on a vascular image.

公开(公告)号：WO2010045373A1

公开(公告)日：2010-04-22

申请号：PCT/US2009/060697

申请日：2009-10-14

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： KUBAN, Barry, D. ,  WHITTAKER, David, R. ,  KLATTE, Ryan, S.

IPC: A61M25/09

CPC classification number: A61M25/09033 ,  A61M25/09041 ,  A61M2025/09116 ,  A61M2205/0266

Abstract: A vascular guidewire system includes a tubular member which at least partially encloses a core wire. A first or distal gripper is connected with a handle to grip a proximal end portion of the tubular member. A second or proximal gripper is disposed in the handle and grips a proximal end portion of the core wire. A first or distal motor is disposed in the handle and is operable to rotate the core wire relative to the outer tubular member. A second or proximal motor is disposed in the handle and is operable to move the first or distal motor longitudinally relative to the handle to thereby move the core wire longitudinally relative to the outer tubular member. The second or proximal motor is disposed in a coaxial relationship with the first or distal motor. Rotational and/or longitudinally directed forces may be manually applied to the handle to move the tubular member and core wire relative to a patient's body.

Abstract translation: 血管导丝系统包括至少部分地包围芯线的管状构件。 第一或远端夹持器与手柄连接以夹持管状构件的近端部分。 第二或近端夹持器设置在手柄中并且夹持芯线的近端部分。 第一或远端马达设置在手柄中并且可操作以相对于外管状构件转动芯线。 第二或近端马达设置在手柄中并且可操作以相对于手柄纵向移动第一或远端马达，从而相对于外管状构件纵向移动芯线。 第二或近端电动机以与第一或远端电动机同轴的关系设置。 旋转和/或纵向力可以手动地施加到手柄以使管状构件和芯线相对于患者的身体移动。

公开(公告)号：WO2005070300A1

公开(公告)日：2005-08-04

申请号：PCT/US2004/002860

申请日：2004-02-02

Applicant: THE CLEVELAND CLINIC FOUNDATION ,  NAIR, Anuja ,  VINCE, Geoffrey, D. ,  KLINGENSMITH, Jon, D. ,  KUBAN, Barry, D.

Inventor： NAIR, Anuja ,  VINCE, Geoffrey, D. ,  KLINGENSMITH, Jon, D. ,  KUBAN, Barry, D.

IPC: A61B8/14

CPC classification number: A61B5/02007 ,  A61B5/726 ,  A61B8/12

Abstract: A system and method is provided for using ultrasound data backscattered from vascular tissue to estimate the transfer function of a catheter (including components attached thereto -- e.g., IVUS console, transducer, etc.). Specifically, in accordance with a first embodiment of the present invention, a computing device (110) is electrically connected to a catheter (120) and used to acquire RF backscattered data from a vascular structure (e.g., a blood vessel, etc.). The backscattered ultrasound data is then used, together with an algorithm, to estimate the transfer function. The transfer function can then be used (at least in a preferred embodiment) to calculate response data for the vascular tissue (i.e., the tissue component of the backscattered ultrasound data).

Abstract translation: 提供了一种用于使用从血管组织反向散射的超声数据来估计导管（包括附接到其上的部件 - 例如IVUS控制台，换能器等）的传递功能的系统和方法。 具体地，根据本发明的第一实施例，计算设备（110）电连接到导管（120）并用于从血管结构（例如，血管等）获取RF背散射数据。 然后将后向散射的超声数据与算法一起用于估计传递函数。 然后可以使用传递函数（至少在一个优选实施例中）来计算血管组织的反应数据（即背散射超声数据的组织分量）。

公开(公告)号：WO2004017835A1

公开(公告)日：2004-03-04

申请号：PCT/US2003/026521

申请日：2003-08-25

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： NAIR, Anuja ,  VINCE, Geoffrey, D. ,  KLINGENSMITH, Jon, D. ,  KUBAN, Barry, D.

IPC: A61B8/12

CPC classification number: A61B8/4461 ,  A61B5/02007 ,  A61B5/0456 ,  A61B8/0833 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4488 ,  A61B8/483 ,  A61B8/543 ,  G06T7/0012 ,  G06T7/12 ,  G06T2207/10132 ,  G06T2207/30048 ,  G06T2207/30101

Abstract: A system and method is provided for using backscattered data and known parameters to characterize vascular tissue. Specifically, in one embodiment of the present invention, an ultrasonic device (120) is used to acquire RF backscattered data (i.e., IVUS data) from a blood vessel. The IVUS data is then transmitted to a computing device (130) and used to create an IVUS image. The blood vessel is then cross-sectioned and used to identify its tissue type and to create a corresponding image (i.e., histology image). A region of interest (ROI), preferably corresponding to the identified tissue type, is then identified on the histology image. The computing device (130), or more particularly, a characterization application (132) operating thereon, is then adapted to identify a corresponding region on the IVUS image. To accurately match the ROI, however, it may be necessary to warp or morph the histology image to substantially fit the contour of the IVUS image. After the corresponding region is identified, the IVUS data that corresponds to this region is identified. Signal processing is then performed and at least one parameter is identified. The identified parameter and the tissue type (e.g., characterization data) is stored in a database (134).

Abstract translation: 提供了一种使用背散射数据和已知参数来表征血管组织的系统和方法。 具体地，在本发明的一个实施例中，使用超声波装置（120）从血管获取RF背散射数据（即，IVUS数据）。 然后将IVUS数据传送到计算设备（130）并用于创建IVUS图像。 然后将血管切片并用于识别其组织类型并产生相应的图像（即，组织学图像）。 然后在组织学图像上识别优选对应于所识别的组织类型的感兴趣区域（ROI）。 然后，计算设备（130），或更具体地，在其上操作的特征应用（132））适于识别IVUS图像上的相应区域。 然而，为了精确地匹配ROI，可能需要使组织学图像变形或变形以基本上适合IVUS图像的轮廓。 识别对应区域后，识别与该区域对应的IVUS数据。 然后执行信号处理，并且识别至少一个参数。 所识别的参数和组织类型（例如表征数据）被存储在数据库（134）中。