公开(公告)号：WO2004017821A2

公开(公告)日：2004-03-04

申请号：PCT/US2003/026492

申请日：2003-08-25

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： KUBAN, Barry, D. ,  KLINGENSMITH, Jon, D. ,  VINCE, D., Geoffrey ,  NAIR, Anuja

IPC: A61B

CPC classification number: A61B8/4461 ,  A61B5/02007 ,  A61B5/0456 ,  A61B8/0833 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4488 ,  A61B8/483 ,  A61B8/543 ,  G06T7/0012 ,  G06T7/12 ,  G06T2207/10132 ,  G06T2207/30048 ,  G06T2207/30101

Abstract: A system and method is provided for substantially synchronizing the acquisition of blood-vessel data to an identifiable portion of heartbeat data. Specifically, a data-gathering device is adapted to acquire heartbeat data and blood-vessel data from a heart-monitoring device and a data-gathering probe, respectively. In a preferred embodiment of the present invention, the blood-vessel data is acquired during a cyclical portion of the heartbeat data. By identifying a cyclical (or commonly reoccurring) portion of the heartbeat data and acquiring blood-vessel data during this cyclical portion (or during an interval that substantially corresponds thereto), the blood vessel can be analyzed as if it were standing still -- i.e., not expanding and relaxing. In one embodiment of the present invention, the heart-monitoring device includes an EKG device, the data-gathering device includes an intra-vascular ultrasound (IVUS) device and a computing device, and the data-gathering probe includes at least one transducer. In another embodiment of the present invention, the data-gathering system further includes a retraction device adapted to move the data-gathering probe though a blood vessel at a substantially steady speed.

Abstract translation: 提供了一种用于将血管数据的获取基本上同步到心跳数据的可识别部分的系统和方法。 具体地，数据收集装置适于分别从心脏监测装置和数据收集探针获取心跳数据和血管数据。 在本发明的优选实施例中，在心跳数据的周期部分期间获取血管数据。 通过在该循环部分（或在与其基本对应的间隔期间）识别心跳数据的周期性（或通常重复发生）部分并获取血管数据，可以分析血管，如同静置时一样 - 即 ，不扩大和放松。 在本发明的一个实施例中，所述心脏监测装置包括EKG装置，所述数据收集装置包括血管内超声（IVUS）装置和计算装置，并且所述数据收集探针包括至少一个换能器。 在本发明的另一个实施例中，数据收集系统还包括一个缩回装置，其适于以基本上稳定的速度移动通过血管的数据收集探针。

公开(公告)号：WO2007047566A3

公开(公告)日：2007-04-26

申请号：PCT/US2006/040334

申请日：2006-10-14

Applicant: THE CLEVELAND CLINIC FOUNDATION ,  NAIR, Anuja ,  KUBAN, Barry, D. ,  VINCE, D., Geoffrey ,  KLINGENSMITH, Jon, David

Inventor： NAIR, Anuja ,  KUBAN, Barry, D. ,  VINCE, D., Geoffrey ,  KLINGENSMITH, Jon, David

IPC: A61B8/14

Abstract: A system and method is provided for using ultrasound data backscattered from vascular tissue to estimate the transfer function of a catheter. In one embodiment of the present invention, a computing device is electrically connected to a catheter and used to acquire R backscattered data from a vascular structure. The backscattered ultrasound data is then used with an algorithm to estimate transfer function(s) which is used to calculate response data for the vascular tissue. In another embodiment, an IVUS console is electrically connected to a catheter and a computing device is used to acquire backscattered data from a vascular structure. The backscattered data is then transmitted to the computing device, where it is used to estimate the catheter's transfer function and to calculate response data for the vascular tissue. The response data and the histology data are then used to characterize at least a portion of the vascular tissue.

公开(公告)号：WO2005091885A3

公开(公告)日：2005-10-06

申请号：PCT/US2005/006159

申请日：2005-02-25

Applicant: THE CLEVELAND CLINIC FOUNDATION ,  KLINGENSMITH, Jon, D. ,  NAIR, Anuja ,  KUBAN, Barry, D. ,  VINCE, D., Geoffrey

Inventor： KLINGENSMITH, Jon, D. ,  NAIR, Anuja ,  KUBAN, Barry, D. ,  VINCE, D., Geoffrey

IPC: A61B18/04 ,  A61B8/00 ,  A61B6/00 ,  A61B5/05

Abstract: A system and method is provided for using the frequency spectrum of a radio frequency (RF) signal backscattered from vascular tissue to identify at least one border ( e.g. , tissue interface, etc.) on a vascular image. Embodiments of the present invention operate in accordance with a data gathering device ( e.g. , an intra-vascular ultrasound (IVUS) device, etc.) electrically connected to a computing device and a transducer via a catheter. The transducer is used to gather radio frequency (RF) data backscattered from vascular tissue. The RF data is then provided to (or acquired by) the computing device via the data-gathering device. In one embodiment of the present invention, the computing device includes (i) at least one data storage device ( e.g. , database, memory, etc.) for storing a plurality of tissue types and parameters related thereto and (ii) at least one application ( e.g. , a characterization application, a gradient-border application, a frequency-border application and/or an active-contour application). The characterization application is used to convert (or transform) the RF data into the frequency domain and to identify a plurality of parameters associated therewith. The identified parameters are then compared to the parameters stored in the data storage device to identify the corresponding tissue type. This information ( e.g. , tissue type, corresponding RF data, etc.) is then used, either alone or together with other border-related information ( e.g. , gradient information, other-border information, etc.), to determine at least one border on a vascular image.