公开(公告)号：WO1996032419A1

公开(公告)日：1996-10-17

申请号：PCT/US1996004476

申请日：1996-04-01

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： THE GENERAL HOSPITAL CORPORATION ,  PAPISOV, Mikhail

IPC: C08B37/00

CPC classification number: C08L59/00 ,  A61K47/59 ,  A61K47/61 ,  A61K47/645 ,  A61K51/1213 ,  C08B37/0021 ,  C08G4/00 ,  C08L2666/26

Abstract: The present invention relates to biodegradable biocompatible polyacetals, methods for their preparation, and methods for treating mammals by administration of biodegradable biocompatible polyacetals. A method for forming the biodegradable biocompatible polyacetals combines a glycol-specific oxidizing agent with a polysaccharide to form an aldehyde intermediate which is combined with a reducing agent to form the biodegradable biocompatible polyacetal. The resultant biodegradable biocompatible polyacetals can be chemically modified to incorporate additional hydrophilic moieties. A method for treating mammals includes the administration of the biodegradable biocompatible polyacetal in which biologically active compounds or diagnostic labels can be disposed.

Abstract translation: 本发明涉及可生物降解的生物相容性聚缩醛，其制备方法以及通过施用可生物降解的生物相容性聚缩醛来治疗哺乳动物的方法。 用于形成可生物降解的生物相容性聚缩醛的方法将二醇特异性氧化剂与多糖组合形成醛中间体，其与还原剂组合以形成可生物降解的生物相容性聚缩醛。 所得到的可生物降解的生物相容性聚缩醛可以被化学修饰以加入额外的亲水部分。 用于治疗哺乳动物的方法包括给予生物活性生物相容性聚缩醛，其中可以处置生物活性化合物或诊断标签。