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    HUNTINGTIN-RELATED THERAPEUTICS AND BIOASSAY
    3.
    发明申请
    HUNTINGTIN-RELATED THERAPEUTICS AND BIOASSAY 审中-公开
    与营养相关的治疗和生物学

    公开(公告)号：WO1998021358A1

    公开(公告)日：1998-05-22

    申请号：PCT/US1997020745

    申请日：1997-11-14

    Applicant: UNIVERSITY OF MASSACHUSETTS ,  THE GENERAL HOSPITAL CORPORATION

    Inventor： UNIVERSITY OF MASSACHUSETTS ,  THE GENERAL HOSPITAL CORPORATION ,  DilFIGLIA, Marian ,  ARONIN, Neil ,  VELIER, James

    IPC: C12Q01/00

    CPC classification number: G01N33/5008 ,  G01N33/502 ,  G01N33/5044 ,  G01N33/5058 ,  G01N33/6896 ,  G01N2500/10

    Abstract: A method of identifying a compound useful in the treatment of a disease characterized by the presence of mutant huntingtin by: (a) providing a cell which expresses mutant huntingtin; (b) contacting the cell with a test compound; and (c) determining whether the level of clathrin-mediated endocytosis is increased in the presence of the test compound, compared to the level in the absence of the test compound. An increase in clathrin-mediated endocytosis is an indication that the test compound is useful in treating the disease.

    Abstract translation: 鉴定通过以下方法鉴定用于治疗特征在于存在突变型亨廷汀的疾病的化合物的方法：（a）提供表达突变型亨廷汀的细胞; （b）使细胞与测试化合物接触; 和（c）与不存在测试化合物的水平相比，确定在测试化合物存在下网格蛋白介导的内吞水平是否增加。 网格蛋白介导的内吞作用的增加表明该试验化合物可用于治疗该疾病。

    MODULATION OF WOUND HEALING BY PHOTODYNAMIC THERAPY
    4.
    发明申请
    MODULATION OF WOUND HEALING BY PHOTODYNAMIC THERAPY 审中-公开
    通过光化疗治疗伤口愈合的调节

    公开(公告)号：WO1998011827A1

    公开(公告)日：1998-03-26

    申请号：PCT/US1997016188

    申请日：1997-09-12

    Applicant: THE GENERAL HOSPITAL CORPORATION

    Inventor： THE GENERAL HOSPITAL CORPORATION ,  TRAUNER, Kenneth ,  HASAN, Tayyaba ,  HAMBLIN, Michael, R.

    IPC: A61B17/00

    CPC classification number: A61B17/00 ,  A61K41/0071 ,  A61N5/062 ,  Y10S977/932

    Abstract: Disclosed is a method for modulating wound healing in a mammal. The method includes the steps of: (a) administering a photosensitizer to a mammal that has an unhealed or partially-healed wound; (b) waiting for the photosensitizer to reach an effective tissue concentration at the wound site; (c) photoactivating the photosensitizer by delivering specifically to the wound site light of an effective wavelength and intensity, for an effective length of time. The modulation of wound healing can include hastening healing by administering a low dose of photodynamic therapy. Alternatively, the modulation can include inhibiting fibrosis by administering a high dose of photodynamic therapy. The photosensitizer can be targeted, for example, to macrophages or myofibroblasts. Targeting can be by conjugation to a targeting moiety such as a protein, peptide or microparticle.

    Abstract translation: 公开了一种调节哺乳动物伤口愈合的方法。 该方法包括以下步骤：（a）向具有未愈合或部分愈合的伤口的哺乳动物施用光敏剂; （b）等待光敏剂在伤口部位达到有效的组织浓度; （c）通过在有效的时间长度内特异性地输送有效波长和强度的伤口部位的光来光敏化光敏剂。 伤口愈合的调节可以包括通过施用低剂量的光动力疗法来加速愈合。 或者，调节可以包括通过施用高剂量的光动力疗法来抑制纤维化。 光敏剂可以靶向例如巨噬细胞或肌成纤维细胞。 靶向可以通过与靶向部分如蛋白质，肽或微粒共轭。

    MELATONIN 1a RECEPTOR GENE REGULATORY REGIONS AND USES THEREOF
    5.
    发明申请
    MELATONIN 1a RECEPTOR GENE REGULATORY REGIONS AND USES THEREOF 审中-公开
    MELATONIN 1a受体基因监管区及其用途

    公开(公告)号：WO1998003549A1

    公开(公告)日：1998-01-29

    申请号：PCT/US1997012526

    申请日：1997-07-17

    Applicant: THE GENERAL HOSPITAL CORPORATION

    Inventor： THE GENERAL HOSPITAL CORPORATION ,  REPPERT, Steven, M.

    IPC: C07K14/72

    CPC classification number: C12N15/85 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/72 ,  C12N2830/00 ,  C12N2830/85

    Abstract: Disclosed are DNAs encoding melatonin 1a receptor gene promoter regions, recombinant polypeptides expressed from such DNAs, and methods of using such expression constructs to screen for promoter activators or inhibitors. Transcriptional activators are useful as therapeutics to reentrain endogenous melatonin rhythms as a means of treating circadian rhythm disorders in humans and control reproductive cycles in seasonally breeding animals. Transcriptional inhibitors are useful as therapeutics to control the initiation or timing of puberty in humans.

    Abstract translation: 公开了编码褪黑激素1a受体基因启动子区域的DNA，从这些DNA表达的重组多肽，以及使用这些表达构建体筛选启动子活化剂或抑制剂的方法。 转录激活剂可用作治疗内源性褪黑素节律作为治疗人类昼夜节律紊乱和控制季节性繁殖动物繁殖周期的手段。 转录抑制剂可用作治疗人类控制青春期的起始或时机。

    OPTICAL BIOPSY FORCEPS AND METHODS OF DIAGNOSING TISSUE
    8.
    发明申请
    OPTICAL BIOPSY FORCEPS AND METHODS OF DIAGNOSING TISSUE 审中-公开
    光学生物力学和诊断组织的方法

    公开(公告)号：WO1997041777A1

    公开(公告)日：1997-11-13

    申请号：PCT/US1997007784

    申请日：1997-05-07

    Applicant: THE GENERAL HOSPITAL CORPORATION

    Inventor： THE GENERAL HOSPITAL CORPORATION ,  NISHIOKA, Norman, S. ,  SCHOMACKER, Kevin, T.

    IPC: A61B10/00

    CPC classification number: A61B10/06 ,  A61B2017/00061 ,  A61B2090/3614

    Abstract: An integrated optical biopsy forceps device (10) and a method for tissue identification by optical analysis and biopsy sampling at a site within the body. The device includes an elongated catheter body for introduction into the body and navigation to an area of interest. An optical fiber (50) extends through the device, from the proximal end, where it may be connected to electro-optical spectral analysis equipment, to a distal tip for illuminating and receiving light energy from tissue at the location of the tip. The distal end of the device has a pair of cutting jaws (80, 81) pivotally mounted at the distal end of the catheter body and controlled by control wires (40, 41) extending through the catheter body to a control handle at the proximal end, or by the optical fiber. The device may be spectroscopically guided to a site of interest within the body. The fiber tip (50) is positioned coaxially with the jaws at the zone of contact and cutting of the jaws, and is retracted as the jaws close, so that the biopsy sample is taken exactly at the spot being viewed by the optical fiber.

    Abstract translation: 一种综合光学活检钳装置（10）以及通过在体内部位进行光学分析和活组织检查取样的组织鉴别方法。 该装置包括用于引入身体并导航到感兴趣区域的细长导管体。 光纤（50）从近端（其可以连接到电光谱分析设备）延伸穿过该设备到远端，用于照射和接收来自尖端位置处的组织的光能。 装置的远端具有一对可枢转地安装在导管主体的远端处的切割钳口（80,81），并由延伸穿过导管主体的控制线（40,41）控制在近端的控制手柄 ，或通过光纤。 该装置可以被光谱地引导到身体内的感兴趣部位。 纤维尖端（50）在钳口的接触和切割区域处与颚骨同轴地定位，并且随着颚关闭而缩回，使得活检样本准确地在被光纤观察的位置处被拍摄。

    ADMINISTRATION OF POLYPEPTIDE GROWTH FACTORS FOLLOWING CENTRAL NERVOUS SYSTEM ISCHEMIA OR TRAUMA
    10.
    发明申请
    ADMINISTRATION OF POLYPEPTIDE GROWTH FACTORS FOLLOWING CENTRAL NERVOUS SYSTEM ISCHEMIA OR TRAUMA 审中-公开
    根据中央神经系统ISCHEMIA或TRAUMA的多肽生长因子的管理

    公开(公告)号：WO1997034618A1

    公开(公告)日：1997-09-25

    申请号：PCT/US1997005071

    申请日：1997-03-21

    Applicant: THE GENERAL HOSPITAL CORPORATION ,  FINKLESTEIN, Seth, P.

    Inventor： THE GENERAL HOSPITAL CORPORATION

    IPC: A61K38/00

    CPC classification number: A61K38/1875

    Abstract: The present invention relates to the treatment of central nervous system injuries by intracisternal or intravenous administration of polypeptide growth factors, such as basic fibroblast growth factor. This method provides significant benefits because administration can occur a substantial amount of time following an injury.

    Abstract translation: 本发明涉及通过内部或静脉内施用多肽生长因子如碱性成纤维细胞生长因子治疗中枢神经系统损伤。 该方法提供了显着的益处，因为在受伤后可能发生大量的时间。

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