公开(公告)号：WO2016187187A1

公开(公告)日：2016-11-24

申请号：PCT/US2016/032845

申请日：2016-05-17

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： ZAPOL, Warren, M. ,  ANDERSON, Rox, R. ,  ZAZZERON, Luca ,  FRANCO, Walfre ,  FARINELLI, William, A.

IPC: A61M1/32 ,  A61M1/34 ,  A61M1/36 ,  A61M1/38

CPC classification number: A61N5/0603 ,  A61B1/2676 ,  A61M11/00 ,  A61M15/009 ,  A61M2202/0233 ,  A61N5/062 ,  A61N2005/0604 ,  A61N2005/0609 ,  A61N2005/063 ,  A61N2005/0651 ,  A61N2005/0652 ,  A61N2005/0655 ,  A61N2005/0662 ,  A61N2005/0663 ,  A61N2005/067 ,  A61M2202/0014

Abstract: Systems and methods are provided for treating or preventing carbon monoxide poisoning. In particular, systems and methods are provided for a phototherapy treatment or prevention system that delivers light radiation to a patient's body to photodissociate carbon monoxide from hemoglobin.

Abstract translation: 提供用于治疗或预防一氧化碳中毒的系统和方法。 特别地，为光疗治疗或预防系统提供了系统和方法，其将光辐射递送到患者的身体以使一氧化碳从血红蛋白中解离。

公开(公告)号：WO2020010286A1

公开(公告)日：2020-01-09

申请号：PCT/US2019/040656

申请日：2019-07-03

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： ZAPOL, Warren, M. ,  ANDERSON, Richard, Rox ,  ZAZZERON, Luca ,  FRANCO, Walfre ,  FANINELLI, William, A. ,  FISCHBACH, Anna

IPC: A61M15/00 ,  A61N5/06

Abstract: Systems and methods for removing carbon monoxide from whole blood are provided. In one configuration, an extracorporeal phototherapy system includes an oxygenator and a light source configured to output light and arranged to emit the light output by the light source onto at least one surface of the oxygenator. The oxygenator includes a plurality of membrane layers each having a plurality of microporous hollow fiber membranes. The plurality of microporous hollow fiber membranes each include an external surface and an internal channel. Each of the plurality of membrane layers may be rotationally offset with respect to an adjacent layer. The oxygenator further includes a gas inlet port in fluid communication with a first end of the internal channels, a gas outlet port in fluid communication a second end of the internal channels, a blood inlet port, and a blood outlet port.

公开(公告)号：WO2017027810A2

公开(公告)日：2017-02-16

申请号：PCT/US2016/046791

申请日：2016-08-12

Applicant: THE GENERAL HOSPITAL CORPORATION ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： MOOTHA, Vamsi K. ,  JAIN, Isha ,  ZAPOL, Warren M. ,  ZAZZERON, Luca

IPC: A61K33/00 ,  A61K31/5377

CPC classification number: A61K31/5377 ,  A61K9/00 ,  A61K31/19 ,  A61K31/194 ,  A61K31/198 ,  A61K31/225 ,  A61K31/44 ,  A61K31/4704 ,  A61K31/472 ,  A61K31/4745 ,  A61K33/00 ,  C07K14/00 ,  G01N33/50 ,  G01N33/5008 ,  G01N33/5041 ,  G01N33/5079 ,  G01N2800/04 ,  G01N2800/7009 ,  G01N2800/7038 ,  G01N2800/7095

Abstract: Methods of promoting hypoxia or the hypoxia response for the treatment or prevention of mitochondrial dysfunction and oxidative stress disorders are described. Methods for screening for targets of mitochondrial dysfunction and oxidative stress disorders are also described.

Abstract translation: 描述了促进缺氧或缺氧反应用于治疗或预防线粒体功能障碍和氧化应激障碍的方法。 还描述了筛选线粒体功能障碍和氧化应激障碍的靶标的方法。