公开(公告)号：WO2012083254A2

公开(公告)日：2012-06-21

申请号：PCT/US2011/065648

申请日：2011-12-16

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  FRIED, Itzhak ,  SUTHANA, Nanthia ,  KNOWLTON, Barbara

Inventor： FRIED, Itzhak ,  SUTHANA, Nanthia ,  KNOWLTON, Barbara

IPC: A61N1/36 ,  A61N1/20 ,  A61N1/05

CPC classification number: A61N1/36082 ,  A61N1/0534 ,  A61N1/36092 ,  A61N1/36139 ,  A61N1/36157

Abstract: A site-specific deep brain stimulation for enhancement of memory is described. A method of the site-specific deep brain stimulation for enhancement of memory may include implanting intracranial depth electrodes in a patient, wherein the electrodes are placed in right and/or left entorhinal regions, and stimulating the electrodes with current set below an after-discharge threshold. The method may include stimulation at a specific brain site in the medial temporal lobe, stimulation (ODTS) at specific stages of information processing. A system for site specific deep brain stimulation of entorhinal regions during specific stages of information processing is also described.

Abstract translation: 描述了用于增强记忆的位点特异性深部脑刺激。 用于增强记忆的位点特异性深部脑刺激的方法可以包括将颅内深度电极植入患者体内，其中电极被放置在右侧和/或左侧内嗅区域中，并且将电流设置在放电后的电流下 阈。 该方法可以包括在信息处理的特定阶段在中间颞叶的特定脑部位的刺激，刺激（ODTS）。 还描述了在信息处理的特定阶段期间针对内部区域的位点特异性深部脑刺激的系统。

公开(公告)号：WO2022251234A1

公开(公告)日：2022-12-01

申请号：PCT/US2022/030751

申请日：2022-05-24

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  FRIED, Itzhak ,  NIR, Yuval ,  GEVA-SAGIV, Maya

Inventor： FRIED, Itzhak ,  NIR, Yuval ,  GEVA-SAGIV, Maya

IPC: A61N1/36

Abstract: A closed-loop neuromodulatory system comprises one or more processors and memory. The system is configured to record signals from a first region of a brain of a human subject during sleep via a first electrode. The system is configured to determine, from the recorded signals, active periods of the first region. The system is configured to stimulate a second region of the brain, different from the first region, during the active periods via a second electrode that is electrically coupled to the first electrode via closed-loop control.

公开(公告)号：WO2015191628A1

公开(公告)日：2015-12-17

申请号：PCT/US2015/034962

申请日：2015-06-09

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： FRIED, Itzhak ,  MARKOVIC, Dejan ,  SUTHANA, Nanthia

IPC: A61N1/05

CPC classification number: A61N1/36082 ,  A61B5/0476 ,  A61B5/0478 ,  A61B5/055 ,  A61B5/4064 ,  A61B5/4094 ,  A61B5/4836 ,  A61B5/6868 ,  A61N1/025 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/36092 ,  A61N1/36125 ,  A61N1/36139 ,  A61N1/37229 ,  G06F19/00 ,  G06F19/3481 ,  G16H50/50

Abstract: Systems and methods for restoring cognitive function are disclosed. In some implementations, a method includes, at a computing device, separately stimulating one or more of lateral and medial entorhinal afferents and other structures connecting to a hippocampus of an animal subject in accordance with a plurality of predefined stimulation patterns, thereby attempting to restore object-specific memories and location-specific memories; collecting a plurality of one or more of macro- and micro-recordings of the stimulation of hippocampalentorhinal cortical (HEC) system; and refining the computational model for restoring individual memories in accordance with a portion of the plurality of one or more of macro- and micro-recordings.

Abstract translation: 公开了恢复认知功能的系统和方法。 在一些实施方式中，一种方法包括在计算设备处，分别刺激根据多个预定义的刺激模式连接到动物对象的海马的侧向和内侧嗅觉传入和其他结构中的一个或多个，从而尝试恢复对象 特定的记忆和位置特定的记忆; 收集海马脑皮层（HEC）系统刺激的多个宏观和微观记录; 以及根据所述多个一个或多个宏和微记录的一部分来细化用于恢复各个存储器的计算模型。

公开(公告)号：WO2015021075A1

公开(公告)日：2015-02-12

申请号：PCT/US2014/049829

申请日：2014-08-05

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  U.M. ACCELMED MEDICAL PARTNERS LP ,  WOLF, Tamir

Inventor： WOLF, Tamir ,  FRIED, Itzhak ,  OREN-BEN, Ilan

IPC: A61N1/18 ,  A61N1/36 ,  A61N1/05

CPC classification number: A61N1/3787 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/3605 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/37229 ,  A61N1/375 ,  A61N1/3756

Abstract: A brain stimulation device includes: a threaded head portion; a needle portion connected to the threaded head portion; at least one wireless power source arranged in proximity to the threaded head portion, the at least one wireless power source being configured to generate electrical energy for the brain stimulation device responsive to a wireless power signal being received by the brain stimulation device; and at least one electrode arranged at least partially on an outside surface of the needle portion in electrical communication with the at least one wireless power source, wherein the at least one electrode is configured to transmit an electrical signal responsive to receiving the electrical energy from the at least one wireless power source. A method of using the brain stimulation device is also described.

Abstract translation: 脑刺激装置包括：螺纹头部; 连接到螺纹头部的针部; 布置在所述螺纹头部附近的至少一个无线电源，所述至少一个无线电源被配置为响应于由所述脑刺激装置接收的无线功率信号而产生用于所述脑刺激装置的电能; 以及至少部分地布置在与所述至少一个无线电源电连通的所述针部分的外表面上的至少一个电极，其中所述至少一个电极被配置为响应于从所述至少一个无线电源接收电能而发送电信号 至少一个无线电源。 还描述了使用脑刺激装置的方法。