公开(公告)号：WO2014165049A1

公开(公告)日：2014-10-09

申请号：PCT/US2014/024242

申请日：2014-03-12

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： GRUNDFEST, Warren, S. ,  KOSTIC, Marko, N.

IPC: A61B5/1455 ,  A61B5/026

CPC classification number: A61B5/7278 ,  A61B5/0062 ,  A61B5/0064 ,  A61B5/01 ,  A61B5/02055 ,  A61B5/0261 ,  A61B5/0285 ,  A61B5/03 ,  A61B5/1079 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6801 ,  A61B5/6832 ,  A61B5/7225 ,  A61B5/742 ,  A61B2560/0214 ,  A61B2560/0223 ,  A61B2562/164

Abstract: The properties inside a human tissue as well as how those properties vary over time can include information of great importance to a healthcare provider. For example, the concentration of hemoglobin, oxygenated or nonoxygenated, blood flow velocity, body temperature, and even change in size of the tissue, can all be relevant to a doctor's understanding of how a wound is healing. In some cases, the tissue of interest may not be easily accessible, as a tissue that is under a cast or beneath a bandage, or may be beneath a layer of skin that makes it difficult to evaluate the tissue visually or in a non-invasive manner. Improved systems and methods for evaluating and monitoring tissues are needed. A system for monitoring tissue at a plurality of depths can include a sensor strip, a data acquisition module and analysis software. The sensor strip can have a first side including a first photodetector element and a plurality of light-emitting elements, wherein the plurality of light-emitting elements are disposed in a predetermined configuration relative to the photodetector element. The data acquisition module can be capable of being coupled to the sensor strip, wherein the data acquisition module is configured to control the sensor strip and store signals received from the light-emitting elements. The analysis software can analyze and/or display the received signals. The system can be adapted to be placed on the surface of a patient's skin, e.g., under a cast, splint, or dressing. The sensor strip can be adapted to be placed over an area of a patient's body, e.g., that has suffered trauma.

Abstract translation: 人体组织内的特性以及这些性质随时间的变化可能包括对医疗保健提供者非常重要的信息。 例如，血红蛋白的浓度，氧合或非氧化，血流速度，体温，甚至组织尺寸的变化，都可以与医生对伤口愈合的理解有关。 在一些情况下，感兴趣的组织可能不容易接近，作为在铸件下面或在绷带下方的组织，或者可能在一层皮肤之下，使得难以在视觉上或非侵入性地评估组织 方式。 需要改进用于评估和监测组织的系统和方法。 用于在多个深度监测组织的系统可以包括传感器条，数据采集模块和分析软件。 传感器条可以具有包括第一光电检测器元件和多个发光元件的第一侧，其中多个发光元件相对于光电检测器元件设置成预定的配置。 数据采集​​模块能够耦合到传感器条，其中数据采集模块被配置为控制传感器条并存储从发光元件接收的信号。 分析软件可以分析和/或显示接收到的信号。 该系统可以适于放置在患者皮肤的表面上，例如在铸件，夹板或敷料之下。 传感器条可以适于放置在患者身体的区域上，例如已经遭受创伤的区域。