公开(公告)号：WO2016094836A1

公开(公告)日：2016-06-16

申请号：PCT/US2015/065323

申请日：2015-12-11

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： MILLS, David A. ,  FRESE, Steven A.

IPC: A01N63/00 ,  A01N63/02

CPC classification number: A61K35/747 ,  A01N63/02 ,  A61K2300/00 ,  C12N1/20 ,  C12R1/225

Abstract: Methods of reducing milk glycans, and thus enteric pathogens that use such glycans as carbon sources, in the gut of nursing mammals.

Abstract translation: 在哺乳哺乳动物的肠道中减少牛奶聚糖以及因此使用这种聚糖作为碳源的肠道病原体的方法。

公开(公告)号：WO2020247389A1

公开(公告)日：2020-12-10

申请号：PCT/US2020/035748

申请日：2020-06-02

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： LEBRILLA, Carlito B. ,  GERMAN, Bruce ,  AMICUCCI, Matthew J. ,  NANDITA, Eshani ,  CASTILLO, Juan ,  MILLS, David A.

IPC: A61K31/702 ,  A61K31/715 ,  C12N9/24

Abstract: Synthetic oligosaccharides and mixtures thereof which resemble polysaccharides produced by plants, yeast and other fungi, bacteria, and algae are described. The oligosaccharides and compositions provided herein are useful as synbiotics, prebiotics, immune modulators, digestion aids, and food additives.

公开(公告)号：WO2013123223A1

公开(公告)日：2013-08-22

申请号：PCT/US2013/026183

申请日：2013-02-14

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： GARRIDO, Daniel ,  GERMAN, J. Bruce ,  LEBRILLA, Carlito B. ,  MILLS, David A.

IPC: C07K7/06 ,  A61K38/08 ,  C12N15/52 ,  A23L1/29

CPC classification number: A61K38/47 ,  A23C9/1216 ,  A23L2/52 ,  A23L33/195 ,  A61K31/715 ,  A61K35/741 ,  A61K38/00 ,  A61K38/40 ,  C07K14/79 ,  C12N9/2402 ,  C12N9/2497 ,  C12P19/04 ,  C12P21/005 ,  C12Y302/01096 ,  Y02P20/52 ,  A61K2300/00

Abstract: Provided herein are deglycosylating enzymes that remove a broad range of N-glycans from N-glycosylated proteins. Further provided are methods of recombinantly producing and expressing the deglycosylating enzymes. The presently described deglycosylating enzymes can be used to produce free glycans for characterization, and for prebiotic and immunostimulatory uses. In addition, the presently described deglycosylating enzymes can be used to produce deglycosylated proteins for characterization, to improve digestion, and to reduce immunogenicity.

Abstract translation: 本文提供了去糖基化酶，其从N-糖基化蛋白质中除去宽范围的N-聚糖。 还提供了重组产生和表达去糖基化酶的方法。 目前描述的去糖基化酶可用于产生用于表征的游离聚糖，以及益生元和免疫刺激用途。 此外，目前描述的去糖基化酶可以用于产生去糖基化的蛋白质用于表征，以改善消化和降低免疫原性。

公开(公告)号：WO2021247703A1

公开(公告)日：2021-12-09

申请号：PCT/US2021/035446

申请日：2021-06-02

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： SHAH, Ishita M. ,  MILLS, David A. ,  GERMAN, J. Bruce ,  CHEN, Xi

IPC: A61K31/702 ,  A61K9/00 ,  A61P11/00 ,  A61P11/06 ,  A61P31/00 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P37/08

Abstract: Methods and compositions for use of human milk oligosaccharides for prevention and treatment of airway viral infections are provided.

公开(公告)号：WO2010105207A1

公开(公告)日：2010-09-16

申请号：PCT/US2010/027206

申请日：2010-03-12

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  DSM FOOD SPECIALTIES USA INC. ,  BARBOZA, Mariana ,  GERMAN, J. Bruce ,  LEBRILLA, Carlito B. ,  MILLS, David A. ,  FREEMAN, Samara ,  KING, William Robert

Inventor： BARBOZA, Mariana ,  GERMAN, J. Bruce ,  LEBRILLA, Carlito B. ,  MILLS, David A. ,  FREEMAN, Samara ,  KING, William Robert

IPC: A61K31/702 ,  A61P1/06 ,  A61P1/14

CPC classification number: A61K31/702 ,  A23L5/00 ,  A23L7/00 ,  A23L29/30 ,  A23L33/125 ,  A23L33/135 ,  A23L33/21 ,  A23L33/40 ,  A23V2002/00 ,  A61K9/0095 ,  A61K35/745 ,  A61K38/47 ,  A61K2035/115 ,  C12Y302/01108 ,  A23V2250/28 ,  A23V2200/3204 ,  A23V2200/3202 ,  A23V2200/32

Abstract: The present invention provides galacto-oligosaccharide compositions that preferentially stimulate growth of specific Bifidobacterium species and subspecies.

Abstract translation: 本发明提供优选刺激特异性双歧杆菌物种和亚种的生长的半乳寡聚糖组合物。