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    GASTROESOPHAGEAL AORTIC OCCLUSION DEVICE AND METHOD
    1.
    发明申请
    GASTROESOPHAGEAL AORTIC OCCLUSION DEVICE AND METHOD 审中-公开

    公开(公告)号：WO2021034823A1

    公开(公告)日：2021-02-25

    申请号：PCT/US2020/046796

    申请日：2020-08-18

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： WARD, Kevin ,  PLOTT, Jeffrey Stephen

    IPC: A61B17/12 ,  A61B17/135 ,  A61M1/00 ,  A61M25/10

    Abstract: A device and method for occluding the descending aorta includes inserting a gastroesophageal resuscitative aortic occlusion device into a stomach of a patient through the esophagus. The gastroesophageal resuscitative aortic occlusion device includes a catheter having a body and a first lumen, and a distal end having a first opening fluidly coupled to the first lumen. An inflatable balloon is disposed on the catheter. An interior of the inflatable balloon is fluidly coupled to the first opening. An inflation device is operably connected to the catheter and fluidly coupled to the first lumen. Activation of the inflation device forces fluid into the interior of the inflatable balloon through the first lumen and the first opening. Activating the inflation device to pressurizes the inflatable balloon with a fluid. An external pressure device applies pressure to the abdomen of the patient until blood flow through the descending aorta is reduced or stopped.

    EPSILON-TUBE FILTER FOR BLUNT NOISE REMOVAL
    2.
    发明申请
    EPSILON-TUBE FILTER FOR BLUNT NOISE REMOVAL 审中-公开
    EPSILON管式滤波器用于滤除噪声

    公开(公告)号：WO2015112266A3

    公开(公告)日：2015-07-30

    申请号：PCT/US2014/069124

    申请日：2014-12-08

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： ANSARI, Sardar ,  WARD, Kevin ,  NAJARIAN, Kayvan

    IPC: A61B8/00 ,  A61B8/02 ,  A61B8/04 ,  A61B8/06

    Abstract: The present application describes techniques to filter signals contaminated with blunt noise. Calculated filter coefficients may be applied to signals to generate filtered output signals without the blunt noise. Sets of filter coefficients may be calculated utilizing an ε-tube filter process in conjunction with an autoregressive exogenous (ARX) model. Sets of filter coefficients may be calculated in accordance with a constrained optimization algorithm using data indicative of a source of the blunt noise. When the blunt noise is modeled in accordance with the ARX model, filtered output signals are generated having amplitudes constrained to a selected Epsilon value, which may be the amplitude of a primary component of the unfiltered signal. A set of filter coefficients may be calculated by determining, from the set of filter coefficients that satisfy the constrained optimization algorithm, a solution that produces a filtered output signal having the most time-invariant frequency composition.

    Abstract translation: 本申请描述了用于过滤受到钝性噪声污染的信号的技术。 计算的滤波器系数可以被施加到信号以生成滤波后的输出信号而没有钝噪声。 滤波器系数组可以利用ε-管滤波器过程结合自回归外生（ARX）模型来计算。 可以使用指示钝噪声源的数据根据​​约束优化算法来计算滤波器系数组。 当根据ARX模型对钝噪声进行建模时，生成滤波后的输出信号，其幅度限制为选定的Epsilon值，该Epsilon值可以是未滤波信号的主分量的幅度。 通过从满足约束优化算法的滤波器系数集合中确定产生具有最大时间不变频率成分的滤波输出信号的解，可以计算一组滤波器系数。

    MULTIPLE ACTUATOR VIBRATION THERAPY
    4.
    发明申请
    MULTIPLE ACTUATOR VIBRATION THERAPY 审中-公开

    公开(公告)号：WO2018157008A2

    公开(公告)日：2018-08-30

    申请号：PCT/US2018/019595

    申请日：2018-02-24

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： EPUREANU, Bogdan ,  WARD, Kevin ,  SAXENA, Himanshu ,  EGILMEZ, Mahmut, Mert

    IPC: A61H1/00 ,  A61H23/02

    Abstract: A method includes disposing a plurality of actuators about a subject, each actuator being configured to generate a respective vibration signal, each vibration signal applying a normal force to the subject, and controlling the plurality of actuators such that the respective vibration signal of each actuator of the plurality has a respective vibration characteristic. Each actuator is oriented such that the respective vibration signal propagates along a longitudinal axis of the subject for stimulation of the subject remote from the plurality of actuators.

    ADAPTIVE EPSILON-TUBE FILTER FOR BLUNT NOISE REMOVAL
    5.
    发明申请
    ADAPTIVE EPSILON-TUBE FILTER FOR BLUNT NOISE REMOVAL 审中-公开
    适用于BLUNT NOISE移除的自适应EPSILON-TUBE过滤器

    公开(公告)号：WO2016160174A1

    公开(公告)日：2016-10-06

    申请号：PCT/US2016/018911

    申请日：2016-02-22

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： ANSARI, Sardar ,  NAJARIAN, Kayvan ,  WARD, Kevin

    IPC: A61B8/04 ,  A61B8/06

    CPC classification number: A61B5/721 ,  A61B5/021 ,  A61B5/031 ,  A61B5/0402 ,  A61B5/0535 ,  A61B5/0836 ,  A61B5/7214 ,  A61B5/725 ,  A61B5/7253 ,  A61B8/488 ,  A61B8/5223 ,  A61B8/5269 ,  A61B8/5276

    Abstract: Techniques for motion artifact (MA) reduction in impedance plethysmography (IP) and other physiological signals are provided. The techniques limit the amplitude of MA filtered signals by imposing an "ε-tube." The techniques may include the introduction of a regularization term to ensure that the pattern of a filtered signal is similar to the pattern of the primary component of the original, unfiltered signal by maximizing the regularity of the filtered signal. The techniques may be integrated into a portable monitoring device, such as an armband, to remove MA from various diagnostic signals and to extract primary signal components for producing enhanced device performance.

    Abstract translation: 提供了阻抗体积描记术（IP）和其他生理信号的运动伪影（MA）减少技术。 该技术通过施加“ε管”来限制MA滤波信号的幅度。 这些技术可以包括引入正则化术语，以通过最大化滤波信号的规律性来确保滤波信号的模式类似于原始未滤波信号的主要分量的模式。 这些技术可以集成到便携式监控设备中，例如臂带，以从各种诊断信号中移除MA并提取主要信号组件以产生增强的设备性能。

    EPSILON-TUBE FILTER FOR BLUNT NOISE REMOVAL
    6.
    发明申请
    EPSILON-TUBE FILTER FOR BLUNT NOISE REMOVAL 审中-公开
    EPSILON-TUBE过滤器用于BLUNN NOISE移除

    公开(公告)号：WO2015112266A2

    公开(公告)日：2015-07-30

    申请号：PCT/US2014/069124

    申请日：2014-12-08

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： ANSARI, Sardar ,  WARD, Kevin ,  NAJARIAN, Kayvan

    IPC: A61B8/00 ,  A61B8/02 ,  A61B8/04 ,  A61B8/06

    CPC classification number: A61B5/7217 ,  A61B5/02 ,  A61B5/0295 ,  A61B5/0535 ,  A61B5/08 ,  A61B5/14551 ,  A61B5/7207 ,  A61B8/488 ,  A61B8/5269

    Abstract: The present application describes techniques to filter signals contaminated with blunt noise. Calculated filter coefficients may be applied to signals to generate filtered output signals without the blunt noise. Sets of filter coefficients may be calculated utilizing an ε-tube filter process in conjunction with an autoregressive exogenous (ARX) model. Sets of filter coefficients may be calculated in accordance with a constrained optimization algorithm using data indicative of a source of the blunt noise. When the blunt noise is modeled in accordance with the ARX model, filtered output signals are generated having amplitudes constrained to a selected Epsilon value, which may be the amplitude of a primary component of the unfiltered signal. A set of filter coefficients may be calculated by determining, from the set of filter coefficients that satisfy the constrained optimization algorithm, a solution that produces a filtered output signal having the most time-invariant frequency composition.

    Abstract translation: 本申请描述了用钝器噪声过滤信号的技术。 可以将计算的滤波器系数施加到信号以产生没有平坦噪声的滤波输出信号。 滤波器系数的集合可以利用ε-管过滤器结合自回归外生（ARX）模型来计算。 滤波器系数的集合可以根据使用指示钝态噪声源的数据的约束优化算法来计算。 当根据ARX模型对钝平均噪声进行建模时，产生经滤波的输出信号，其幅度被限制到所选择的Epsilon值，该值可以是未滤波信号的主要分量的振幅。 可以通过从满足约束优化算法的滤波器系数的集合确定产生具有最多时间不变频率合成的滤波输出信号的解，来计算一组滤波器系数。

    EARLY DETECTION OF HEMODYNAMIC DECOMPENSATION USING TAUT-STRING TRANSFORMATION
    7.
    发明申请
    EARLY DETECTION OF HEMODYNAMIC DECOMPENSATION USING TAUT-STRING TRANSFORMATION 审中-公开
    早期检测使用TAUT-STRING转换的HEMODYMM DECOMPENSATION

    公开(公告)号：WO2015200750A1

    公开(公告)日：2015-12-30

    申请号：PCT/US2015/037882

    申请日：2015-06-26

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： NAJARIAN, Kayvan ,  BELLE, Ashwin ,  WARD, Kevin ,  DERKSEN, Harm

    IPC: A61N1/08 ,  A61N1/365

    CPC classification number: A61B5/7253 ,  G06F19/00 ,  G16H50/20

    Abstract: Techniques develop models for classification for physical conditions of a subject based on monitored physiologic signal data. The models for classification are determined from data transformed and feature extracted using a Taut- string transformation and in some instances using a further Stockwell-transformation, applied in parallel or in series. Physical conditions, specifying the state of hemodynamic stability and reflective of the cardiovascular and nervous systems, are thus modeled using these techniques.

    Abstract translation: 技术基于监测的生理信号数据开发用于物体状况分类的模型。 用于分类的模型是通过使用Taut-string变换提取的数据转换和特征确定的，并且在某些情况下使用并行或串联应用的另一个Stockwell变换。 因此，使用这些技术来建模指定血液动力学稳定性和心血管和神经系统反映的状态。

    EPSILON-TUBE FILTER FOR BLUNT NOISE REMOVAL
    8.
    发明申请
    EPSILON-TUBE FILTER FOR BLUNT NOISE REMOVAL 审中-公开

    公开(公告)号：WO2015112266A9

    公开(公告)日：2015-07-30

    申请号：PCT/US2014/069124

    申请日：2014-12-08

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： ANSARI, Sardar ,  WARD, Kevin ,  NAJARIAN, Kayvan

    IPC: A61B8/00 ,  A61B8/02 ,  A61B8/04 ,  A61B8/06

    Abstract: The present application describes techniques to filter signals contaminated with blunt noise. Calculated filter coefficients may be applied to signals to generate filtered output signals without the blunt noise. Sets of filter coefficients may be calculated utilizing an ε-tube filter process in conjunction with an autoregressive exogenous (ARX) model. Sets of filter coefficients may be calculated in accordance with a constrained optimization algorithm using data indicative of a source of the blunt noise. When the blunt noise is modeled in accordance with the ARX model, filtered output signals are generated having amplitudes constrained to a selected Epsilon value, which may be the amplitude of a primary component of the unfiltered signal. A set of filter coefficients may be calculated by determining, from the set of filter coefficients that satisfy the constrained optimization algorithm, a solution that produces a filtered output signal having the most time-invariant frequency composition.

    MULTIPLE ACTUATOR VIBRATION THERAPY
    10.
    发明申请
    MULTIPLE ACTUATOR VIBRATION THERAPY 审中-公开

    公开(公告)号：WO2018157008A3

    公开(公告)日：2018-08-30

    申请号：PCT/US2018/019595

    申请日：2018-02-24

    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    Inventor： EPUREANU, Bogdan ,  WARD, Kevin ,  SAXENA, Himanshu ,  EGILMEZ, Mahmut, Mert

    IPC: A61H1/00 ,  A61H23/02

    Abstract: A method includes disposing a plurality of actuators about a subject, each actuator being configured to generate a respective vibration signal, each vibration signal applying a normal force to the subject, and controlling the plurality of actuators such that the respective vibration signal of each actuator of the plurality has a respective vibration characteristic. Each actuator is oriented such that the respective vibration signal propagates along a longitudinal axis of the subject for stimulation of the subject remote from the plurality of actuators.

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