公开(公告)号：WO2006138627A2

公开(公告)日：2006-12-28

申请号：PCT/US2006/023590

申请日：2006-06-16

Applicant: INHIBITEX, INC. ,  THE TEXAS A & M UNIVERSITY SYSTEM ,  PATTI, Joseph, M. ,  HUTCHINS, Jeff, T. ,  HALL, Andrea ,  SANTOS, Linda ,  HOOK, Magnus ,  BOWDEN, Maria

Inventor： PATTI, Joseph, M. ,  HUTCHINS, Jeff, T. ,  HALL, Andrea ,  SANTOS, Linda ,  HOOK, Magnus ,  BOWDEN, Maria

IPC: A61K39/40

CPC classification number: C07K16/1271 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/92

Abstract: Monoclonal antibodies which can bind to the SdrF protein of Staphylococcus epidermidis are provided which can be useful in the treatment and protection against infection from staphylococcal bacteria such as Staphylococcus epidermidis . The monoclonal antibodies of the invention are advantageous in that they can also recognize binding domains and subdomains of the S. epidermidis SdrF protein in addition to the protein itself. Suitable compositions and passive vaccines based on the monoclonal antibodies of the invention, as well as methods for their use, are also provided.

Abstract translation: 提供可结合表皮葡萄球菌的SdrF蛋白的单克隆抗体，其可用于治疗和保护葡萄球菌如表皮葡萄球菌感染。 本发明的单克隆抗体是有利的，除了蛋白质本身之外，它们还可以识别表皮葡萄球菌SdrF蛋白的结合结构域和亚结构域。 还提供了基于本发明的单克隆抗体的合适的组合物和被动疫苗以及它们的使用方法。

公开(公告)号：WO2002074324A1

公开(公告)日：2002-09-26

申请号：PCT/US2002/007807

申请日：2002-03-15

Applicant: THE TEXAS A & M UNIVERSITY SYSTEM

Inventor： HOOK, Magnus ,  BOWDEN, Maria

IPC: A61K38/00

CPC classification number: A61K39/085 ,  A61K38/465 ,  A61K2039/505 ,  C07K16/1271 ,  C07K16/40 ,  G01N33/56938

Abstract: An Isolated lipase, designated GehD , from S. epidermidis has now been found to bind to collagen, and thus this protein may be used in methods of preventing or treating staphylococcal infections. The invention contemplates the use of compositions including GehD, vaccines containing GehD, and antibodies that can recognize GehD, and these are advantageously used with human or animal patients which may be susceptible to staphylococcal disease. In addition, medical instruments or biological implants can be treated using the collagen-binding protein of the invention in order to reduce or eliminate the possibility of their becoming infected or further spreading a staphylococcal infection.

Abstract translation: 来自i的分离的脂肪酶，指定为GehD 。 已经发现表皮细胞与胶原蛋白结合，因此该蛋白质可用于预防或治疗葡萄球菌感染的方法中。 本发明考虑使用包含GehD，含有GehD的疫苗和可以识别GehD的抗体的组合物，并且它们有利地与可能对葡萄球菌病易感的人或动物患者一起使用。 此外，可以使用本发明的胶原结合蛋白来治疗医疗器械或生物植入物，以减少或消除其变得感染或进一步扩散葡萄球菌感染的可能性。