公开(公告)号：WO2021252620A2

公开(公告)日：2021-12-16

申请号：PCT/US2021/036606

申请日：2021-06-09

Applicant: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY ,  WEINER, David ,  MUTHUMANI, Kar ,  PARZYCH, Elizabeth

Inventor： WEINER, David ,  MUTHUMANI, Kar ,  PARZYCH, Elizabeth

IPC: A61K39/12 ,  A61K39/215 ,  A61K39/395 ,  A61P31/14 ,  C12N15/86 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/54 ,  A61K39/42 ,  C07K16/10 ,  C07K2317/41 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2770/20034

Abstract: Disclosed herein are antibodies to SARS-CoV-2 antigens and recombinant nucleic acid sequences that encode the SARS-CoV-2 antibodies. The disclosure also provides a method of preventing and/or treating a SARS-CoV-2 infection or disease or disorder associated with SARS-CoV-2 infection (e.g., COVID-19) in a subject using said compositions and methods.

公开(公告)号：WO2021226343A1

公开(公告)日：2021-11-11

申请号：PCT/US2021/031104

申请日：2021-05-06

Applicant: THE WISTAR INSTITUTE OF ANATOMY ANDBIOLOGY

Inventor： MUTHUMANI, Kar ,  WEINER, David

IPC: A61K39/12 ,  A61K39/42 ,  C07K16/10

Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to a Hepatitis B viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating a Hepatitis B virus infection in a subject using said composition and method of generation.

公开(公告)号：WO2021022113A1

公开(公告)日：2021-02-04

申请号：PCT/US2020/044408

申请日：2020-07-31

Applicant: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY

Inventor： WEINER, David ,  PATEL, Ami

IPC: A61K31/407 ,  A61K35/76 ,  A61K39/00 ,  A61K39/395

Abstract: Disclosed herein are compositions for generating a synthetic antibody or synthetic multivalent antibody in a subject. Also disclosed are methods for generating a synthetic antibody or synthetic multivalent antibody in a subject by administering a composition including a recombinant nucleic acid sequence that encodes an antibody, a synthetic antibody, or a synthetic multivalent antibody to a subject. The disclosure also provides compositions and methods of preventing and/or treating a bacterial infection in a subject using said antibody, synthetic antibody, or synthetic multivalent antibody.

公开(公告)号：WO2020086782A1

公开(公告)日：2020-04-30

申请号：PCT/US2019/057750

申请日：2019-10-24

Applicant: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY ,  INOVIO PHARMACEUTICALS, INC.

Inventor： WEINER, David ,  WISE, Megan, C. ,  ZU, Ziyang

IPC: A61K39/395 ,  A61P31/18 ,  C07K16/10

Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to an HIV antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an HIV infection in a subject using said composition and method of generation.

公开(公告)号：WO2019241497A1

公开(公告)日：2019-12-19

申请号：PCT/US2019/036940

申请日：2019-06-13

Applicant: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY

Inventor： WEINER, David ,  MUTHUMANI, Kar

IPC: A61K39/12 ,  A61K39/395 ,  A61P31/14 ,  C07K14/18 ,  C07K16/10

Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to a Zika viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an Zika virus infection in a subject using said composition and method of generation.

公开(公告)号：WO2019161163A1

公开(公告)日：2019-08-22

申请号：PCT/US2019/018159

申请日：2019-02-15

Applicant: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY

Inventor： WEINER, David ,  PERALES PUCHALT, Alfredo

IPC: A61K39/245 ,  A61K39/12

Abstract: Nucleic acid molecules and compositions comprising one or more nucleotide sequences that encode a consensus Epstein-Barr virus (EBV) antigen. Immunomodulatory methods and methods of inducing an immune response against EBV are disclosed. Method of treating infection by EBV and methods of treating or preventing a disease or disorder associated with EBV are disclosed. Modified consensus EBV antigens are disclosed.

公开(公告)号：WO2019152599A1

公开(公告)日：2019-08-08

申请号：PCT/US2019/015972

申请日：2019-01-31

Applicant: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY

Inventor： WEINER, David ,  KHOSHNEJAD, Makan ,  MUTHUMANI, Kar ,  PATEL, Ami

IPC: C07K16/00 ,  C12N15/09 ,  C07K16/32 ,  A61K39/395 ,  A61K48/00

Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets PCSK9. The disclosure also provides a method of preventing and/or treating disease, such as cardiovascular disease or hypercholesterolemia, in a subject using the composition of the invention.

公开(公告)号：WO2023064841A1

公开(公告)日：2023-04-20

申请号：PCT/US2022/078020

申请日：2022-10-13

Applicant: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY ,  WEINER, David ,  PARZYCH, Elizabeth ,  SMITH, Trevor ,  PATEL, Ami ,  KULP, Daniel

Inventor： WEINER, David ,  PARZYCH, Elizabeth ,  SMITH, Trevor ,  PATEL, Ami ,  KULP, Daniel

IPC: C07K16/10 ,  A61K39/42 ,  C07K14/165

Abstract: Disclosed herein are antibodies to SARS-CoV-2 antigens and recombinant nucleic acid sequences that encode the SARS-CoV-2 antibodies. The disclosure also provides a method of preventing and/or treating a SARS-CoV-2 infection or disease or disorder associated with SARS-CoV-2 infection (e.g., COVID-19) in a subject using said compositions and methods.

公开(公告)号：WO2021173829A1

公开(公告)日：2021-09-02

申请号：PCT/US2021/019662

申请日：2021-02-25

Applicant: INOVIO PHARMACEUTICALS, INC. ,  THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY ,  YAN, Jian ,  BRODERICK, Kate ,  WEINER, David ,  MUTHUMANI, Kar ,  PATEL, Ami

Inventor： YAN, Jian ,  BRODERICK, Kate ,  WEINER, David ,  MUTHUMANI, Kar ,  PATEL, Ami

IPC: A61P31/14 ,  A61K39/215 ,  A61K39/12

Abstract: Disclosed herein are nucleic acid molecules encoding a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a SARS-CoV-2 infection in a subject.

公开(公告)号：WO2021022107A1

公开(公告)日：2021-02-04

申请号：PCT/US2020/044396

申请日：2020-07-31

Applicant: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY

Inventor： WEINER, David

IPC: A61K39/40 ,  C07K16/12

Abstract: Disclosed herein are compositions for generating a synthetic antibody or synthetic multivalent antibody in a subject. Also disclosed are methods for generating a synthetic antibody or synthetic multivalent antibody in a subject by administering a composition including one or more recombinant nucleic acid sequence that encodes a synthetic antibody or synthetic multivalent antibody to the subject. The disclosure also provides a compositions and methods of preventing and/or treating a Neisseria gonorrhoeae infection in a subject using said synthetic antibody or synthetic multivalent antibody.