公开(公告)号：WO2019089523A1

公开(公告)日：2019-05-09

申请号：PCT/US2018/058120

申请日：2018-10-30

Applicant: THERACAINE LLC

Inventor： SAWAN, Samuel, P.

IPC: C07D487/04

CPC classification number: C07D213/04 ,  C07C237/04 ,  C07C309/06 ,  C07C309/12 ,  C07C309/39 ,  C07D211/60

Abstract: The invention provides hydrohphobic drug salts and pharmaceutical compositions comprising such salts. The invention fourther provides compositions for delivering poorly soluble drugs, including hydrophobic drug salts.

公开(公告)号：WO2019089540A1

公开(公告)日：2019-05-09

申请号：PCT/US2018/058141

申请日：2018-10-30

Applicant: THERACAINE LLC

Inventor： SAWAN, Samuel, P.

IPC: A61K31/445 ,  A61K47/20 ,  A61P23/02

Abstract: The invention provides acid addition salts of a basic therapeutic agent wherein the represented by Formula (I) or Formula (II) ArSO 3 H, wherein Ar, R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein. The invention also provides pharmaceutical compositions comprising a pharmaceutically acceptable carrier or excipient and an acid addition salt of the invention and a method of using an acid addition salt of the invention for treating a disease or disorder in a subject in need thereof.

公开(公告)号：WO2019089521A1

公开(公告)日：2019-05-09

申请号：PCT/US2018/058118

申请日：2018-10-30

Applicant: THERACAINE LLC

Inventor： SAWAN, Samuel, P.

IPC: A61K31/519 ,  C07D487/14

Abstract: The invention provides acid addition salts of a basic therapeutic agent wherein the acid is represented by Formula I, R-X (I), wherein R is a haloalkyl group and X is -SO3H, C(O)OH or P(O)(OR 1 )(OH), where R 1 is hydrogen or C 1 -C 6 -alkyl. The invention also provides pharmaceutical compositions comprising a pharmaceutically acceptable carrier or excipient and an acid addition salt of the invention and a method of using an acid addition salt of the invention for treating a disease or disorder in a subject in need thereof.