SYNTHESIS OF [18F] FLUOROMETHYL BENZENE USING BENZYL PENTAFLUOROBENZENESULFONATE
    2.
    发明申请
    SYNTHESIS OF [18F] FLUOROMETHYL BENZENE USING BENZYL PENTAFLUOROBENZENESULFONATE 审中-公开
    合成[18F]使用苯甲酰基苯甲酸酯的氟代苯甲酸酯

    公开(公告)号:WO2008106442A1

    公开(公告)日:2008-09-04

    申请号:PCT/US2008/055003

    申请日:2008-02-26

    IPC分类号: C07D451/00

    摘要: The present invention discloses the reactivity of ponytail ("PT") sulfonates as leaving groups in nucleophilic fluorination reactions. The results showed that using a pentafluorobenzenesulfonate precursor is a suitable leaving group for n. c. a. nucleophilic 18 F-fluorination in synthesis of [ 18 F]fluoromethyl benzene, wherein this is a suitable leaving group for 18F-labeling with moderate reactivity. The PT-precursor seems to be quite stable. In an attempt to purify the crude 18F-labeled product using fluorous solid phase extraction (F-SPE), the radio labeled impurities decreased significantly. This provides an opportunity for utilizing PT methodology in both simple and fast purification methods.

    摘要翻译: 本发明公开了在亲核氟化反应中马尾)(“PT”)磺酸盐作为离去基团的反应性。 结果表明,使用五氟苯磺酸盐前体是适合的n离去基团。 C。 一个。 合成[18 F F]氟甲基苯中的亲核18 F-氟化,其中这是适当的离去基团,用中等反应性进行18F标记。 PT前体似乎相当稳定。 为了使用氟固相萃取(F-SPE)纯化粗制的18F标记产物,放射性标记的杂质显着降低。 这提供了在简单和快速纯化方法中利用PT方法的机会。

    AROMATIC SULFONATION REACTIONS
    3.
    发明申请
    AROMATIC SULFONATION REACTIONS 审中-公开
    AROMATIC SULFONATION反应

    公开(公告)号:WO02030878A1

    公开(公告)日:2002-04-18

    申请号:PCT/GB2001/004427

    申请日:2001-10-05

    摘要: A process for the sulfonation of an aromatic compound wherein the aromatic compound and sulfonating agent are admixed in the presence of an ionic liquid is described. The method for the sulfonation of aromatic compounds in (e.g. water stable) ionic liquids offers advantages over conventional sulfonation reactions. These are that no by-products formed, the ionic liquid is not consumed and the sulfonating agent (e.g. SO3) is relatively inexpensive.

    摘要翻译: 描述了芳族化合物磺化的方法,其中芳族化合物和磺化剂在离子液体存在下混合。 芳族化合物在(例如水稳定)离子液体中磺化的方法提供了优于常规磺化反应的优点。 这些是没有形成副产物,离子液体不被消耗,并且磺化剂(例如SO 3)相对便宜。

    PROCESS FOR SULFONATING HALOBENZENE DERIVATIVES WITH SULFUR TRIOXIDE
    8.
    发明申请
    PROCESS FOR SULFONATING HALOBENZENE DERIVATIVES WITH SULFUR TRIOXIDE 审中-公开
    硫化三氧化硫硫化氢衍生物的方法

    公开(公告)号:WO2014029666A1

    公开(公告)日:2014-02-27

    申请号:PCT/EP2013/066909

    申请日:2013-08-13

    IPC分类号: C07C303/06 C07C309/39

    摘要: A process for sulfonating at least one halobenzene with sulfur trioxide (SO 3 ) comprising the following steps : Step 1. manufacturing a gaseous mixture [mixture (M)] comprising SO 3 and at least one additional gas different from SO 3 by oxidizing sulfur dioxide in the presence of at least one catalyst, wherein the SO 3 content in mixture (M) is from 1 to 95 % by volume, relative to the total volume of mixture (M); and Step 2. contacting said mixture (M) with said at least one halobenzene.

    摘要翻译: 一种用三氧化硫(SO 3)磺化至少一种卤代苯的方法,包括以下步骤:步骤1.通过在存在下氧化二氧化硫制备包含SO 3和至少一种不同于SO 3的另外的气体的气体混合物[混合物(M) 的至少一种催化剂,其中混合物(M)中的SO 3含量相对于混合物(M)的总体积为1至95体积%; 和步骤2.使所述混合物(M)与所述至少一种卤代苯接触。