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    DIBENZO[B,F][1,4]OXAZAPINE COMPOUNDS
    2.
    发明申请
    DIBENZO[B,F][1,4]OXAZAPINE COMPOUNDS 审中-公开
    二苯并[B，F] [1,4]氧杂化合物

    公开(公告)号：WO2008112900A1

    公开(公告)日：2008-09-18

    申请号：PCT/US2008/056866

    申请日：2008-03-13

    申请人： ARYX THERAPEUTICS, INC. ,  BECKER, Cyrus ,  RUBENS, Courtney ,  ADAMS, Jason ,  PALME, Monica ,  DRUZGALA, Pascal

    发明人： BECKER, Cyrus ,  RUBENS, Courtney ,  ADAMS, Jason ,  PALME, Monica ,  DRUZGALA, Pascal

    IPC分类号： C07D405/14 ,  C07D413/04 ,  C07D453/02 ,  A61K31/553 ,  A61P25/00

    CPC分类号： C07D413/04 ,  C07D405/14 ,  C07D453/02

    摘要： The present invention relates to 11-(piperazin-l-yl)dibenzo[b, f ][l,4]oxazapine compounds of the formula I (I) where the variables are as defined herein, their salts and pharmaceutically acceptable compositions thereof. Methods of preparing these compounds are also described. These compounds may be used in the treatment of disorders such as schizophrenia, treatment resistant schizophrenia, bipolar disorder, psychotic depression, treatment resistant depression, schizophrenia-associated depression, treatment resistant OCD, autism, senile psychosis, psychotic dementia, L-DOPA induced psychosis, psychogenic polydipsia, psychotic symptoms of neurological disorders, sleep disorders.

    摘要翻译： 本发明涉及式I（I）的11-（哌嗪-1-基）二苯并[b，f] [1,4]恶唑烷化合物，其中变量如本文所定义，其盐和药学上可接受的组合物。 还描述了制备这些化合物的方法。 这些化合物可用于治疗精神分裂症，治疗耐药性精神分裂症，双相性精神障碍，精神病抑郁症，治疗耐药性抑郁症，精神分裂症相关抑郁症，治疗耐药性OCD，孤独症，老年性精神病，精神病性痴呆，L-DOPA诱发的精神病 ，心理性多饮，精神病性神经障碍症状，睡眠障碍。

    ANTIARRHYTHMIC PRECURSOR COMPOUNDS, METHODS OF SYNTHESIS AND METHODS OF USE
    3.
    发明申请
    ANTIARRHYTHMIC PRECURSOR COMPOUNDS, METHODS OF SYNTHESIS AND METHODS OF USE 审中-公开
    抗心律失常前体化合物，合成方法和使用方法

    公开(公告)号：WO2007011835A2

    公开(公告)日：2007-01-25

    申请号：PCT/US2006/027599

    申请日：2006-07-14

    申请人： ARYX THERAPEUTICS ,  DRUZGALA, Pascal ,  TIEN, Jien-Heh, J. ,  COOPER, Art ,  BECKER, Cyrus

    发明人： DRUZGALA, Pascal ,  TIEN, Jien-Heh, J. ,  COOPER, Art ,  BECKER, Cyrus

    IPC分类号： C07D493/04 ,  A61K31/35

    CPC分类号： C07D307/80 ,  C07D493/04

    摘要： The invention comprises compounds of Formula 1: wherein, R 1 is independently H or halogen; R 2 is, for example, H or -R 10 -NR 11 R 12 , and wherein R 10 is C1-C6 alkyl, and R 11 and R 12 are independently H, C 1 -C 4 alkyl, and hydrates, solvates, salts and tautomers thereof. The invention further comprises methods for making the compounds of the invention and methods for making compounds useful in the treatment or prevention of cardiac arrhythmia from the compounds of the invention.

    摘要翻译： 本发明包括式1的化合物：其中，R 1独立地为H或卤素; 例如，R 2是H或-R 10 -NR 11 R 12，并且其中R 10选自H， 并且R 11和R 12独立地为H，C 1 -C 4 - 亚烷基 烷基及其水合物，溶剂化物，盐和互变异构体。 本发明进一步包括制备本发明化合物的方法和制备可用于治疗或预防本发明化合物引起的心律失常的化合物的方法。

    MATERIALS AND METHODS FOR TREATING COAGULATION DISORDERS
    5.
    发明申请
    MATERIALS AND METHODS FOR TREATING COAGULATION DISORDERS 审中-公开
    用于治疗凝血障碍的材料和方法

    公开(公告)号：WO2005100336A1

    公开(公告)日：2005-10-27

    申请号：PCT/US2005/012091

    申请日：2005-04-08

    申请人： ARYX THERAPEUTICS ,  DRUZGALA, Pascal ,  BECKER, Cyrus

    发明人： DRUZGALA, Pascal ,  BECKER, Cyrus

    IPC分类号： C07D311/56

    CPC分类号： C07D311/56

    摘要： The subject invention provides anticoagulant compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R 1 , R 3 , n and Ar are as defined herein. The compounds of the subject invention can be used to treat at-risk populations thereby bringing relief of symptoms, improving the quality of life, preventing acute and long-term complications, reducing mortality and treating accompanying disorders. The invention further comprises pharmaceutical compositions comprising the compounds and salts of the invention, as well as methods of using the compounds, salts, and compositions of the invention.

    摘要翻译： 本发明提供式（I）的抗凝血剂化合物及其药学上可接受的盐，其中R 1，R 3，n和Ar如本文所定义。 本发明的化合物可用于治疗危险人群，从而减轻症状，改善生活质量，预防急性和长期并发症，降低死亡率和治疗伴随的疾病。 本发明还包括包含本发明的化合物和盐的药物组合物，以及使用本发明化合物，盐和组合物的方法。

    TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE USING PIPERIDINE DERIVATIVES
    8.
    发明申请
    TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE USING PIPERIDINE DERIVATIVES 审中-公开

    公开(公告)号：WO2001093849A3

    公开(公告)日：2001-12-13

    申请号：PCT/US2001/018365

    申请日：2001-06-07

    申请人： ARYX THERAPEUTICS ,  DRUZGALA, Pascal ,  MILNER, Peter, G. ,  PFISTER, Jurg ,  BECKER, Cyrus

    发明人： DRUZGALA, Pascal ,  MILNER, Peter, G. ,  PFISTER, Jurg ,  BECKER, Cyrus

    IPC分类号： A61K31/4468

    摘要： The subject invention provides novel compounds and compositions for the safe and effective treatment of gastroesophageal reflux and related conditions. In a preferred embodiment, the compositions of the subject invention comprise esterified cisapride derivatives. These compositions possess potent activity in treating gastroesophageal reflux disease and substantially reduce adverse effects associated with the administration of cisapride. These adverse effects include, but are not limited to, diarrhea, abdominal cramping and elevations of blood pressure and heart rate. Said compounds are also useful in Alzheimer's disease, schizophrenia, mania, obsessive-compulsive disorder, depression and anxiety, essential hypertension and sleep disorders.