公开(公告)号：WO2013059947A1

公开(公告)日：2013-05-02

申请号：PCT/CH2012/000185

申请日：2012-08-13

Applicant: TOFWERK AG ,  KNOCHENMUSS, Richard

Inventor： KNOCHENMUSS, Richard

IPC: G01N27/62 ,  G06F17/00 ,  H01J49/00

CPC classification number: G01N27/622 ,  H01J49/02 ,  H01J49/061 ,  H01J49/40

Abstract: The invention relates to a method and an apparatus (1) for determining a mobility of ions. The method includes the steps of modulating an ion beam (6) with an ion gate (2) which is controlled by a modulation function for generating a modulated ion beam, of guiding the modulated ion beam through a drifting region (3), of measuring a signal of the modulated ion beam after the modulated ion beam has passed the drifting region (3) and of calculating a correlation of the modulation function and the signal in order to determine the mobility of the ions. The apparatus (1) includes the ion gate (2), the drifting region (3) through which the modulated ion beam is guidable, a detector (4) by which the signal of the modulated ion beam is measurable after the modulated ion beam has passed the drifting region (3) and a calculation unit (5) by which the correlation of the modulation function and the signal is caiculable in order to determine the mobility of the ions. An autocorrelation of the modulation function is a two-valued function.

Abstract translation: 本发明涉及一种用于确定离子迁移率的方法和装置（1）。 该方法包括以下步骤：用离子栅极（2）调制离子束（6），该离子栅极（2）由用于产生调制离子束的调制功能控制，将调制离子束引导通过漂移区域（3），测量 调制离子束已经通过漂移区域（3）后的调制离子束的信号，并计算调制函数和信号的相关性，以便确定离子的迁移率。 装置（1）包括离子门（2），经调制的离子束可引导的漂移区域（3），经调制的离子束具有调制离子束的信号可被测量的检测器（4） 通过漂移区域（3）和计算单元（5），通过该计算单元（5），调制函数和信号的相关性是可调的，以便确定离子的迁移率。 调制函数的自相关是一个二值函数。

公开(公告)号：WO2014085938A1

公开(公告)日：2014-06-12

申请号：PCT/CH2013/000173

申请日：2013-09-27

Applicant: TOFWERK AG

Inventor： KNOCHENMUSS, Richard

IPC: H01J49/00

CPC classification number: H01J49/0009 ,  G01N30/7206 ,  H01J49/0422 ,  H01J49/0495 ,  H01J49/40

Abstract: A method of calibrating mass-to-charge ratio measurements obtained from a mass spectrometer connected in fluid communication with a chromatographic system comprises the steps of acquiring a multiplicity of mass spectra of an analyte during an analytical run, analyzing at least some of the multiplicity of mass spectra during the analytical run for generating result data relating to a decision on introduction of a calibrant material into the mass spectrometer; and introducing the calibrant material into the mass spectrometer during the analytical run, based on the result data. An arrangement for mass analysis that is suitable for carrying out the method comprises a chromatographic system ( 10), a mass spectrometer (20) connected downstream, in fluid communication to the chromatographic system ( 10), a data acquisition device (22) for acquiring mass spectra of an analyte fed to the mass spectrometer (20), a controllable injector (30, 31 ) to introduce calibrant material into the mass spectrometer, and a control unit (50) receiving information on the acquired mass spectra from the data acquisition device (22), the control unit (50) configured to dynamically control the injector (30, 31 ) based on the received information.

Abstract translation: 校准从与色谱系统流体连通的质谱仪获得的质荷比测量的方法包括以下步骤：在分析运行期间获取分析物的多个质谱，分析多个 用于生成与将校准物质引入质谱仪的决定有关的结果数据的分析运行期间的质谱; 并根据结果数据在分析运行期间将校准物质引入质谱仪。 适用于进行该方法的质量分析装置包括与色谱系统（10）流体连通的色谱系统（10），下游连接的质谱仪（20），数据采集装置（22），用于获取 馈送到质谱仪（20）的分析物的质谱图，将校准物质引入质谱仪的可控注入器（30,31）以及从数据采集装置接收关于所获取的质谱的信息的控制单元（50） （22），所述控制单元（50）被配置为基于所接收的信息来动态地控制所述喷射器（30,31）。

公开(公告)号：WO2014026298A1

公开(公告)日：2014-02-20

申请号：PCT/CH2013/000103

申请日：2013-06-12

Applicant: TOFWERK AG

Inventor： KNOCHENMUSS, Richard

IPC: G01N15/02 ,  H01J49/00

CPC classification number: G01N15/02 ,  G01N2015/0026 ,  G01N2015/0046 ,  H01J49/0031 ,  H01J49/40

Abstract: The invention relates to a method and an apparatus (1) for determining an aerosol particle size distribution. The method includes the steps of modulating an aerosol particle beam (6) with an aerosol particle gate (2) which is controlled by a modulation function for generating a modulated aerosol particle beam, of guiding the modulated aerosol particle beam through a drifting region (3), of measuring a signal of the modulated aerosol particle beam after the modulated aerosol particle beam has passed the drifting region (3) and of calculating a correlation of the modulation function and the signal in order to determine the size distribution of the aerosol particles. The apparatus (1) includes an aerosol particle gate (2) which is controlled by a modulation function for generating from an aerosol particle beam (6) a modulated aerosol particle beam, a drifting region (3) through which the modulated aerosol particle beam is guidable, a detector (4) by which the signal of the modulated aerosol particle beam is measurable after the modulated aerosol particle beam has passed the drifting region (3) and a calculation unit (5) by which the correlation of the modulation function and the signal is calculable in order to determine the size distribution of the aerosol particles.

Abstract translation: 本发明涉及一种用于确定气溶胶粒度分布的方法和装置（1）。 该方法包括以下步骤：用气溶胶颗粒栅极（2）调节气溶胶粒子束（6），该气溶胶颗粒栅极（2）由用于产生经调制的气溶胶粒子束的调制函数控制，将经调制的气溶胶颗粒束引导通过漂移区域（3 ），测量经调制的气溶胶颗粒束已经通过漂移区域（3）后调制的气溶胶粒子束的信号，并计算调制函数和信号的相关性，以确定气溶胶颗粒的尺寸分布。 装置（1）包括气溶胶粒子门（2），其由调制功能控制，用于从气溶胶粒子束（6）产生经调制的气溶胶粒子束，漂移区域（3），经调制的气溶胶颗粒束 可调节的探测器（4），经调制的气溶胶颗粒束已经通过漂移区域（3）和调制功能与 信号是可计算的，以便确定气溶胶颗粒的尺寸分布。

公开(公告)号：WO2019020196A1

公开(公告)日：2019-01-31

申请号：PCT/EP2017/069198

申请日：2017-07-28

Applicant: TOFWERK AG

Inventor： KNOCHENMUSS, Richard ,  ROHNER, Urs

IPC: H01J49/00 ,  H01J49/06 ,  H01J49/22 ,  H01J49/40

CPC classification number: H01J49/403 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/22

Abstract: The invention relates to an apparatus (1) and a method for determining a mass spectrum from a continuous ion beam (50). The method comprises a deflection phase of deflecting the ion beam (50) away from an initial direction to a deflected ion beam (51) by applying a timely changing deflecting force with a deflection unit (3) to ions in the ion beam passing a deflection zone (52), whereby a direction of the deflected ion beam (51) is changed in time according to a deflection modulation function. The method further comprises a pass phase of passing the deflected ion beam (51) to a position sensitive detector (4), a detection phase of detecting with the position sensitive detector (4) the ions of the deflected ion beam (51), whereby ion arrival information is obtained for each detected ion, and a mass spectrum determination phase of determining the mass spectrum from the ion arrival information of the detected ions and the deflection modulation function by a calculation unit (5). Thereby, at a first point in time, the deflected ion beam (51) has a first direction, and later, at a second point in time, the deflected ion beam (51) has for a first time since the first point in time again the first direction, while between the first point in time and the second point in time, the direction of the deflected ion beam (51) differs from the first direction and is changed in time away from directions taken up since the first point in time, wherein at least at a third point in time which is either before the first point in time or after the second point in time, the deflected ion beam (51) has a same direction as at a fourth point in time between the first point in time and the second point in time. Additionally, the method comprises a base change rate estimation step of estimating a base change rate for running the deflection modulation function at, wherein if the deflection modulation function is run at the base change rate, a time interval between the first point in time and the second point in time is longer than a difference between times slowest and fastest ions expected in the ion beam (50) require to pass from a centre of the deflection zone (52) to the position sensitive detector (4), wherein the mass spectrum is determined from the ion beam (50) with the deflection phase, the pass phase, the detection phase and the mass spectrum determination phase by running the deflection modulation function at an effective change rate which is larger than the base change rate.

公开(公告)号：WO2015131293A1

公开(公告)日：2015-09-11

申请号：PCT/CH2014/000027

申请日：2014-03-04

Applicant: TOFWERK AG

Inventor： KNOCHENMUSS, Richard

IPC: G01N30/46 ,  G01N30/62 ,  G01N30/86 ,  G01N30/72

CPC classification number: G01N30/466 ,  G01N30/72 ,  G01N30/86 ,  G01N30/8658 ,  G01N2030/025 ,  G01N2030/027 ,  G01N2030/623 ,  G01N2030/628 ,  G01N2030/862

Abstract: The invention relates to a method and an apparatus for determining a chromatogram. The method includes a first step where a sample is inserted in two separation columns (2.1, 2.2, 2.3), wherein for each separation column (2.1, 2.2, 2.3), a corresponding part of the sample is inserted in the respective separation column (2. 1, 2.2, 2.3) with a corresponding insertion device (3. 1, 3.2, 3.3) which is controlled by a corresponding modulation function for generating a corresponding modulated part of the sample in the respective separation column (2. 1, 2.2, 2.3), wherein the modulation functions with which the parts of the sample are modulated in the separation columns (2. 1, 2.2, 2.3) differ from each other. Furthermore, the method includes a second step where each modulated part of the sample is guided through the respective separation column (2. 1, 2.2, 2.3), a third step where a signal of each modulated part of the sample is measured with a same detector (4) after having passed the respective separation column (2.1, 2.2, 2.3), and a fourth step where for each separation column (2. 1, 2.2, 2.3), a correlation of the signal and the modulation function with which the corresponding part of the sample is modulated in the respective separation column (2. 1, 2.2, 2.3) is calculated in order to determine the chromatogram of the respective separation column (2. 1, 2.2, 2.3).

Abstract translation: 本发明涉及一种用于确定色谱图的方法和装置。 该方法包括将样品插入两个分离柱（2.1,2.2,2.3）中的第一步骤，其中对于每个分离柱（2.1,2.2,2.3），将样品的相应部分插入相应的分离柱（ 具有相应的插入装置（3.1,3.2,3.3），其由相应的调制功能控制，用于在相应的分离柱（2.,1.2,2.2,2.3）中产生样品的相应调制部分 ，2.3），其中在分离柱（2.1,1.2,2.3）中调制样品部分的调制函数彼此不同。 此外，该方法包括第二步骤，其中将样品的每个调制部分引导通过相应的分离柱（2.1,1.2,2.3），第三步骤，其中测量样品的每个调制部分的信号 检测器（4）在经过相应的分离柱（2.1,2.2,2.3）之后，第四步骤，对于每个分离柱（2.1,1.2,2.3），信号和调制函数的相关性 计算相应部分的样品在相应的分离柱（2.2.1,2.3,2.3）中，以确定相应分离柱（2.1,1.2,2.3）的色谱图。