公开(公告)号：WO2023036881A1

公开(公告)日：2023-03-16

申请号：PCT/EP2022/075018

申请日：2022-09-08

Applicant: TOFWERK AG

Inventor： GONIN, Marc

IPC: H01M10/05 ,  G01M3/00 ,  G01N27/00 ,  H01M10/42 ,  H01M50/10 ,  H01M50/20 ,  H01J49/00 ,  H01M10/48 ,  G01M3/20 ,  G01M3/22

Abstract: The invention relates to a method for detecting one or more leaks in a battery enclosure (101) of a battery (100), the battery (100) including at least one electrochemical cell (102) enclosed in the battery enclosure (101), or detecting one or more leaks in the at least one electrochemical cell (102) being in the battery enclosure (101) or separate from the battery enclosure (101). The method comprises the steps of obtaining gas, in particular air, from a surrounding of the battery (100) or from a surrounding of the at least one electrochemical cell (102) being in the battery enclosure (101) or separate from the battery enclosure (101), respectively, obtaining an analysis of the gas by analysing the gas with an analysis method and determining on the basis of the analysis whether the gas includes a signature of at least one constituent part of the at least one electrochemical cell (102), the signature indicating a presence of the at least one constituent part of the at least one electrochemical cell (102) in the gas. In case it is determined on the basis of the analysis that the gas includes the signature of the at least one constituent part of the at least one electrochemical cell (102), a leak in the battery enclosure (102) of the battery (100) or in the at least one electrochemical cell (102) being in the battery enclosure (101) or separate from the battery enclosure (101), respectively, is detected. In the analysis method, the gas is ionised by an ionisation source (31) with an ionisation method to ions and the ions are analysed in an analyser (32) by being separated according to one or more physical properties, wherein the ionisation source (31) is a chemical ionisation source and the ionisation method is a chemical ionisation method. The invention further relates to an apparatus (1) for detecting one or more leaks in a battery enclosure (101) of a battery (100) with the method according to the invention.

公开(公告)号：WO2019149903A1

公开(公告)日：2019-08-08

申请号：PCT/EP2019/052533

申请日：2019-02-01

Applicant: TOFWERK AG

Inventor： GONIN, Marc ,  LOPEZ-HILFIKER, Felipe ,  HUTTERLI, Manuel ,  ERB, Matthias ,  PFANDER, Marc

IPC: H01J49/04

Abstract: The invention relates to an autosampler (1) for obtaining mass spectra from a plurality of fluid samples, in particular gaseous samples. This autosampler (1) comprises a plurality of containers (2.1, 2.2, 2.3, 2.4, 2.5, 2.6) comprising sample sources (3.1, 3.2, 3.3, 3.4, 3.5, 3.6) providing the samples, wherein each one of the containers (2.1, 2.2, 2.3, 2.4, 2.5, 2.6) provides a docking port (4.1, 4.2, 4.3, 4.4, 4.5, 4.6) for being connected with a connector (5) for enabling access to an inside of the respective container (2.1, 2.2, 2.3, 2.4, 2.5, 2.6) via the connector (5) when the connector (5) is connected to the respective docking port (4.1, 4.2, 4.3, 4.4, 4.5, 4.6) in order to obtain the respective sample from the respective container (2.1, 2.2, 2.3, 2.4, 2.5, 2.6) via said connector (5). Thereby, the connector (5) is connectable to and detachable from each docking port (4.1, 4.2, 4.3, 4.4, 4.5, 4.6). The autosampler (1) further comprise an ionisation source (6) for ionising at least a part of the samples to ions, wherein the ionisation source (6) is fluidly coupled to the connector (5) for receiving the samples from the containers (2.1, 2.2, 2.3, 2.4, 2.5, 2.6) via the connector (5). Furthermore, the autosampler (1) comprises a mass analyser (7) for obtaining the mass spectra from the ions, the mass analyser (7) being fluidly coupled to the ionisation source (6) for receiving the ions from the ionisation source (6) for obtaining the mass spectra from the ions. The ionisation source (6) is moveable with the connector (5) within the autosampler (1) sequentially to each one of the plurality of said containers (2.1, 2.2, 2.3, 2.4, 2.5, 2.6) for connecting the connector (5) to the docking port (4.1, 4.2, 4.3, 4.4, 4.5, 4.6) of the respective container (2.1, 2.2, 2.3, 2.4, 2.5, 2.6) for collecting the sample from the respective container (2.1, 2.2, 2.3, 2.4, 2.5, 2.6) for ionising at least a part of the sample to ions and obtaining the mass spectra from the ions. Furthermore, the invention relates to a method for operating the autosampler (1).

公开(公告)号：WO2013059947A1

公开(公告)日：2013-05-02

申请号：PCT/CH2012/000185

申请日：2012-08-13

Applicant: TOFWERK AG ,  KNOCHENMUSS, Richard

Inventor： KNOCHENMUSS, Richard

IPC: G01N27/62 ,  G06F17/00 ,  H01J49/00

CPC classification number: G01N27/622 ,  H01J49/02 ,  H01J49/061 ,  H01J49/40

Abstract: The invention relates to a method and an apparatus (1) for determining a mobility of ions. The method includes the steps of modulating an ion beam (6) with an ion gate (2) which is controlled by a modulation function for generating a modulated ion beam, of guiding the modulated ion beam through a drifting region (3), of measuring a signal of the modulated ion beam after the modulated ion beam has passed the drifting region (3) and of calculating a correlation of the modulation function and the signal in order to determine the mobility of the ions. The apparatus (1) includes the ion gate (2), the drifting region (3) through which the modulated ion beam is guidable, a detector (4) by which the signal of the modulated ion beam is measurable after the modulated ion beam has passed the drifting region (3) and a calculation unit (5) by which the correlation of the modulation function and the signal is caiculable in order to determine the mobility of the ions. An autocorrelation of the modulation function is a two-valued function.

Abstract translation: 本发明涉及一种用于确定离子迁移率的方法和装置（1）。 该方法包括以下步骤：用离子栅极（2）调制离子束（6），该离子栅极（2）由用于产生调制离子束的调制功能控制，将调制离子束引导通过漂移区域（3），测量 调制离子束已经通过漂移区域（3）后的调制离子束的信号，并计算调制函数和信号的相关性，以便确定离子的迁移率。 装置（1）包括离子门（2），经调制的离子束可引导的漂移区域（3），经调制的离子束具有调制离子束的信号可被测量的检测器（4） 通过漂移区域（3）和计算单元（5），通过该计算单元（5），调制函数和信号的相关性是可调的，以便确定离子的迁移率。 调制函数的自相关是一个二值函数。

公开(公告)号：WO2019020196A1

公开(公告)日：2019-01-31

申请号：PCT/EP2017/069198

申请日：2017-07-28

Applicant: TOFWERK AG

Inventor： KNOCHENMUSS, Richard ,  ROHNER, Urs

IPC: H01J49/00 ,  H01J49/06 ,  H01J49/22 ,  H01J49/40

CPC classification number: H01J49/403 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/22

Abstract: The invention relates to an apparatus (1) and a method for determining a mass spectrum from a continuous ion beam (50). The method comprises a deflection phase of deflecting the ion beam (50) away from an initial direction to a deflected ion beam (51) by applying a timely changing deflecting force with a deflection unit (3) to ions in the ion beam passing a deflection zone (52), whereby a direction of the deflected ion beam (51) is changed in time according to a deflection modulation function. The method further comprises a pass phase of passing the deflected ion beam (51) to a position sensitive detector (4), a detection phase of detecting with the position sensitive detector (4) the ions of the deflected ion beam (51), whereby ion arrival information is obtained for each detected ion, and a mass spectrum determination phase of determining the mass spectrum from the ion arrival information of the detected ions and the deflection modulation function by a calculation unit (5). Thereby, at a first point in time, the deflected ion beam (51) has a first direction, and later, at a second point in time, the deflected ion beam (51) has for a first time since the first point in time again the first direction, while between the first point in time and the second point in time, the direction of the deflected ion beam (51) differs from the first direction and is changed in time away from directions taken up since the first point in time, wherein at least at a third point in time which is either before the first point in time or after the second point in time, the deflected ion beam (51) has a same direction as at a fourth point in time between the first point in time and the second point in time. Additionally, the method comprises a base change rate estimation step of estimating a base change rate for running the deflection modulation function at, wherein if the deflection modulation function is run at the base change rate, a time interval between the first point in time and the second point in time is longer than a difference between times slowest and fastest ions expected in the ion beam (50) require to pass from a centre of the deflection zone (52) to the position sensitive detector (4), wherein the mass spectrum is determined from the ion beam (50) with the deflection phase, the pass phase, the detection phase and the mass spectrum determination phase by running the deflection modulation function at an effective change rate which is larger than the base change rate.

公开(公告)号：WO2018046083A1

公开(公告)日：2018-03-15

申请号：PCT/EP2016/071120

申请日：2016-09-07

Applicant: TOFWERK AG

Inventor： LOPEZ-HILFIKER, Felipe ,  GONIN, Marc ,  CUBISON, Mike

IPC: H01J49/04 ,  H01J49/16 ,  G01N33/00

Abstract: The invention relates to an apparatus (1) and a method for analysing a chemical composition of aerosol particles. The apparatus (1) comprises an extractive electronspray ionisation source (2) for extracting components, in particular organic compounds, from the aerosol particles and for ionising the components to ions, and a mass analyser (3), in particular a time-of-flight mass analyser, for analysing the ions, the mass analyser (3) fluidly coupled to the extractive electronspray ionisation source (2). The method includes the steps of extracting components, in particular organic compounds, from the aerosol particles with an extractive electronspray ionisation source (2) and ionising the components with the extractive electronspray ionisation source (2) to ions, transferring the ions to a mass analyser (3), in particular a time-of-flight mass analyser, the mass analyser (3) being fluidly coupled to the extractive electronspray ionisation source (2), and analysing the ions with the mass analyser (3).

Abstract translation: 本发明涉及用于分析气溶胶颗粒的化学组成的设备（1）和方法。 该装置（1）包括用于从气溶胶颗粒中提取组分特别是有机化合物并用于将组分离子化的萃取电子喷射离子源（2），以及质量分析器（3），特别是时间 - 飞行质量分析器，用于分析离子，质量分析器（3）流体耦合到提取电子喷射离子源（2）。 该方法包括以下步骤：用萃取电子喷射离子源（2）从气溶胶粒子萃取组分，特别是有机化合物，并用萃取电子喷射离子源（2）将组分离子化成离子，将离子转移到质量分析仪 （3），特别是飞行时间质量分析器，所述质量分析器（3）流体耦合到所述提取电子喷射离子源（2），并且利用所述质量分析器（3）分析所述离子。

公开(公告)号：WO2015131293A1

公开(公告)日：2015-09-11

申请号：PCT/CH2014/000027

申请日：2014-03-04

Applicant: TOFWERK AG

Inventor： KNOCHENMUSS, Richard

IPC: G01N30/46 ,  G01N30/62 ,  G01N30/86 ,  G01N30/72

CPC classification number: G01N30/466 ,  G01N30/72 ,  G01N30/86 ,  G01N30/8658 ,  G01N2030/025 ,  G01N2030/027 ,  G01N2030/623 ,  G01N2030/628 ,  G01N2030/862

Abstract: The invention relates to a method and an apparatus for determining a chromatogram. The method includes a first step where a sample is inserted in two separation columns (2.1, 2.2, 2.3), wherein for each separation column (2.1, 2.2, 2.3), a corresponding part of the sample is inserted in the respective separation column (2. 1, 2.2, 2.3) with a corresponding insertion device (3. 1, 3.2, 3.3) which is controlled by a corresponding modulation function for generating a corresponding modulated part of the sample in the respective separation column (2. 1, 2.2, 2.3), wherein the modulation functions with which the parts of the sample are modulated in the separation columns (2. 1, 2.2, 2.3) differ from each other. Furthermore, the method includes a second step where each modulated part of the sample is guided through the respective separation column (2. 1, 2.2, 2.3), a third step where a signal of each modulated part of the sample is measured with a same detector (4) after having passed the respective separation column (2.1, 2.2, 2.3), and a fourth step where for each separation column (2. 1, 2.2, 2.3), a correlation of the signal and the modulation function with which the corresponding part of the sample is modulated in the respective separation column (2. 1, 2.2, 2.3) is calculated in order to determine the chromatogram of the respective separation column (2. 1, 2.2, 2.3).

Abstract translation: 本发明涉及一种用于确定色谱图的方法和装置。 该方法包括将样品插入两个分离柱（2.1,2.2,2.3）中的第一步骤，其中对于每个分离柱（2.1,2.2,2.3），将样品的相应部分插入相应的分离柱（ 具有相应的插入装置（3.1,3.2,3.3），其由相应的调制功能控制，用于在相应的分离柱（2.,1.2,2.2,2.3）中产生样品的相应调制部分 ，2.3），其中在分离柱（2.1,1.2,2.3）中调制样品部分的调制函数彼此不同。 此外，该方法包括第二步骤，其中将样品的每个调制部分引导通过相应的分离柱（2.1,1.2,2.3），第三步骤，其中测量样品的每个调制部分的信号 检测器（4）在经过相应的分离柱（2.1,2.2,2.3）之后，第四步骤，对于每个分离柱（2.1,1.2,2.3），信号和调制函数的相关性 计算相应部分的样品在相应的分离柱（2.2.1,2.3,2.3）中，以确定相应分离柱（2.1,1.2,2.3）的色谱图。

公开(公告)号：WO2021198462A1

公开(公告)日：2021-10-07

申请号：PCT/EP2021/058695

申请日：2021-04-01

Applicant: TOFWERK AG

Inventor： TANNER, Martin

IPC: H05H1/30 ,  H01J49/10 ,  H05H1/46 ,  H01J49/105 ,  H05H1/461 ,  H05H2242/00 ,  H05H2245/00

Abstract: The invention relates to a microwave driven plasma ion source (1) for ionising a sample to be ionised to sample ions, the microwave driven plasma ion source (1) including a sample intake (6) for inserting the sample from an outside of the microwave driven plasma ion source (1) into an inside (3) of the microwave driven plasma ion source (1); a microwave generator (10) for generating microwaves for generating a plasma (101) from a plasma gas (100); a plasma torch (20) providing a plasma torch orientation direction (29) having an inside (21) for housing (2) a process of generation of the plasma (101) from the plasma gas (100) and for housing a process of ionising the sample to the sample ions by exposing the sample to the plasma (101), wherein the plasma torch (20) comprises a torch outlet (22) for letting out the plasma (101) and the sample ions from the inside (21) of the plasma torch (20) essentially in the plasma torch orientation direction (29) to an outside of the plasma torch (20), the torch outlet (22) having a torch aperture. Furthermore the microwave driven plasma ion source (1, 201) includes a shielding (4) for shielding off the microwaves from passing from the inside (3) of the microwave driven plasma ion source (1) to the outside of the microwave driven plasma ion source (1), wherein the shielding (4) comprises a shielding outlet (5) for letting out the plasma (101) and the sample ions from the inside (3) of the microwave driven plasma ion source (1) essentially in the plasma torch orientation direction (29) to the outside of the microwave driven plasma ion source (1), the shielding outlet (5) having a shielding aperture. Thereby, the shielding outlet (5) is fluidly coupled to the torch outlet (22) for letting out the plasma (101) and the sample ions from the inside (21) of the plasma torch (20) essentially in the plasma torch orientation direction (29) to the outside of the microwave driven plasma ion source (1), wherein a size of the shielding aperture is less than 150%, preferably less than 125%, particular preferably less than 110% of a size of the torch aperture, wherein both the size of the shielding aperture and the size of the torch aperture are measured in units of area.

公开(公告)号：WO2021083894A1

公开(公告)日：2021-05-06

申请号：PCT/EP2020/080181

申请日：2020-10-27

Applicant: TOFWERK AG

Inventor： KLEE, Sonja ,  PLET, Benoit ,  ROHNER, Urs ,  STOERMER, Carsten

IPC: H01J49/10 ,  H01J49/00

Abstract: The invention relates to a method for mass analysing a first sample by ionising the first sample to first sample ions and obtaining mass spectra from the first sample ions with a mass analyser (207), wherein two or more assays are obtained from the first sample and each one of the assays is transferred to another first ion source (205.1, 205.2) and ionised by the respective first ion source (205.1, 205.2) to first sample ions. Thereby, the first sample is mass analysed in cycles, wherein in each cycle, consecutively for each one of the first ion sources (205.1, 205.2), the first sample ions ionised by the respective one of the first ion sources (205.1, 205.2) are transferred to the mass analyser (207) and at least one mass spectrum is obtained with the mass analyser (207) from the first sample ions ionised by and transferred from the respective one of the first ion sources (205.1, 205.2), the at least one mass spectrum being assigned to the respective one of the first ion sources (205.1, 205.2).

公开(公告)号：WO2019077137A1

公开(公告)日：2019-04-25

申请号：PCT/EP2018/078774

申请日：2018-10-19

Applicant: TOFWERK AG

Inventor： LOPEZ-HILFIKER, Felipe ,  HUTTERLI, Manuel

IPC: H01J49/14 ,  H01J49/06

CPC classification number: H01J49/049 ,  G01N1/2226 ,  G01N33/46 ,  G01N2001/2241 ,  G01N2035/0429 ,  H01J49/062 ,  H01J49/145

Abstract: An ion molecule reactor for generating analyte ions from analytes comprises: a) a reaction volume in which reagent ions can interact with the analytes in order to form analyte ions; b) at least one analyte inlet for introducing the analytes along an inlet path into the reaction volume whereby the inlet path runs essentially along at least a first section of the predefined transit path in the reaction volume; c) at least one reagent ion source and/or at least one reagent ion inlet for providing reagent ions into the reaction volume; d) at least one ion guide comprising an electrode arrangement which is configured for producing an alternating electrical, magnetic and/or electromagnetic field, that allows for guiding the reagent ions and/or the analyte ions at least along a section of the predefined transit path, preferably along the whole transit path, through the reaction volume.

公开(公告)号：WO2014085938A1

公开(公告)日：2014-06-12

申请号：PCT/CH2013/000173

申请日：2013-09-27

Applicant: TOFWERK AG

Inventor： KNOCHENMUSS, Richard

IPC: H01J49/00

CPC classification number: H01J49/0009 ,  G01N30/7206 ,  H01J49/0422 ,  H01J49/0495 ,  H01J49/40

Abstract: A method of calibrating mass-to-charge ratio measurements obtained from a mass spectrometer connected in fluid communication with a chromatographic system comprises the steps of acquiring a multiplicity of mass spectra of an analyte during an analytical run, analyzing at least some of the multiplicity of mass spectra during the analytical run for generating result data relating to a decision on introduction of a calibrant material into the mass spectrometer; and introducing the calibrant material into the mass spectrometer during the analytical run, based on the result data. An arrangement for mass analysis that is suitable for carrying out the method comprises a chromatographic system ( 10), a mass spectrometer (20) connected downstream, in fluid communication to the chromatographic system ( 10), a data acquisition device (22) for acquiring mass spectra of an analyte fed to the mass spectrometer (20), a controllable injector (30, 31 ) to introduce calibrant material into the mass spectrometer, and a control unit (50) receiving information on the acquired mass spectra from the data acquisition device (22), the control unit (50) configured to dynamically control the injector (30, 31 ) based on the received information.

Abstract translation: 校准从与色谱系统流体连通的质谱仪获得的质荷比测量的方法包括以下步骤：在分析运行期间获取分析物的多个质谱，分析多个 用于生成与将校准物质引入质谱仪的决定有关的结果数据的分析运行期间的质谱; 并根据结果数据在分析运行期间将校准物质引入质谱仪。 适用于进行该方法的质量分析装置包括与色谱系统（10）流体连通的色谱系统（10），下游连接的质谱仪（20），数据采集装置（22），用于获取 馈送到质谱仪（20）的分析物的质谱图，将校准物质引入质谱仪的可控注入器（30,31）以及从数据采集装置接收关于所获取的质谱的信息的控制单元（50） （22），所述控制单元（50）被配置为基于所接收的信息来动态地控制所述喷射器（30,31）。