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公开(公告)号：WO2017066412A3
公开(公告)日：2017-04-20
申请号：PCT/US2016/056785
申请日：2016-10-13
Applicant: TOKITAE LLC
Inventor： CHOU, Fong-Li , ECKHOFF, Philip A. , FOWLER, Lawrence Morgan , LIU, Shieng , MAIER-LAXHUBER, Peter K. , PETERSON, Nels R. , SCHMIDT, Ralf W. , TEGREENE, Clarence T. , WOOD, Lowell L., Jr. , WÖRZ, Reinier M. , YAGER, David J.
Abstract: Portage storage containers including controlled evaporative cooling systems are described herein. In some embodiments, a portable container including an integral controlled evaporative cooling system includes: a storage region, an evaporative region adjacent to the storage region, a desiccant region adjacent to the outside of the container, and an insulation region positioned between the evaporative region and the desiccant region. A vapor conduit with an attached vapor control unit has a first end within the evaporative region and a second end within the desiccant region. In some embodiments, the controlled evaporative cooling systems are positioned in a radial configuration within the portable container.
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2.发明申请
公开(公告)号：WO2016179215A1
公开(公告)日：2016-11-10
申请号：PCT/US2016/030658
申请日：2016-05-04
Applicant: TOKITAE LLC
Inventor： CHOU, Fong-Li , ECKHOFF, Philip A. , FOWLER, Lawrence Morgan , GATES, William , HU, Jenny Ezu , ISHIKAWA, Muriel Y. , LARUSSON, Fridrik , LIU, Shieng , MYHRVOLD, Nathan P. , PAL, Brian L. , PETERSON, Nels R. , PIECH, David Keith , VECCHIONE, Maurizio , WOOD, Lowell L., Jr. , WOOD, Victoria Y.H. , YAGER, David J.
CPC classification number: F25D16/00 , F25B23/006 , F25D11/006
Abstract: In some embodiments, a refrigeration device includes: walls substantially forming a liquid-impermeable container configured to hold phase change material internal to a refrigeration device; at least one active refrigeration unit including a set of evaporator coils positioned within an interior of the liquid-impermeable container; walls substantially forming a storage region; and a heat transfer system including a first group of vapor-impermeable structures with a hollow interior connected to form a condenser in thermal contact with the walls substantially forming a liquid-impermeable container, a second group of vapor-impermeable structures with a hollow interior connected to form an evaporator in thermal contact with the walls substantially forming a storage region, and a connector with a hollow interior affixed to both the condenser and the evaporator, the connector forming a liquid and vapor flow path between the hollow interior of the condenser and the hollow interior of the evaporator.
Abstract translation: 在一些实施例中，制冷装置包括：基本上形成液体不可渗透容器的壁，其构造成将相变材料保持在制冷装置内部; 至少一个主动制冷单元，其包括位于所述液体不可渗透容器内部的一组蒸发器盘管; 基本上形成存储区域的壁; 以及传热系统，其包括具有中空内部的第一组不透气结构，以形成基本上形成液体不可渗透容器的与所述壁热接触的冷凝器，具有中空内部连接的第二组蒸气不可渗透结构 以形成与基本上形成存储区域的壁热接触的蒸发器，以及具有固定到冷凝器和蒸发器两者的中空内部的连接器，所述连接器在冷凝器的中空内部和所述冷凝器之间形成液体和蒸气流动路径 中空的蒸发器内部。
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3.发明申请
公开(公告)号：WO2015081058A1
公开(公告)日：2015-06-04
申请号：PCT/US2014/067275
申请日：2014-11-25
Applicant: TOKITAE LLC , CHOU, Fong-Li , LARUSSON, Fridrik , LIU, Shieng
Inventor： CHOU, Fong-Li , LARUSSON, Fridrik , LIU, Shieng , ECKHOFF, Philip A. , FOWLER, Lawrence Morgan , GATES, William , HU, Jennifer Ezu , ISHIKAWA, Muriel Y. , MYHRVOLD, Nathan P. , PETERSON, Nels R. , TEGREENE, Clarence T. , VECCHIONE, Maurizio , WOOD, Lowell L., Jr. , WOOD, Victoria Y., H.
CPC classification number: F25D11/025 , F25B23/006 , F25B2500/01 , F25D11/006 , F28F3/14 , F28F2210/02 , F28F2255/18
Abstract: In some embodiments, a refrigeration device includes: walls substantially forming a liquid-impermeable container configured to hold phase change material internal to the refrigeration device; at least one active refrigeration unit including a set of evaporator coils positioned at least partially within the liquid-impermeable container; a unidirectional thermal conductor with a condensing end and an evaporative end, the condensing end positioned within the liquid-impermeable container; a first aperture in the liquid-impermeable container, the first aperture of a size, shape and position to permit the set of evaporator coils to traverse the aperture; a second aperture in the liquid-impermeable container, the second aperture including an internal surface of a size, shape and position to mate with an external surface of the unidirectional thermal conductor; and one or more walls substantially forming a storage region in thermal contact with the evaporative end of the unidirectional thermal conductor.
Abstract translation: 在一些实施例中，制冷装置包括：基本上形成液体不可渗透容器的壁，其构造成在制冷装置内部保持相变材料; 至少一个主动制冷单元，其包括至少部分地定位在所述液体不可渗透容器内的一组蒸发器盘管; 具有冷凝端和蒸发端的单向热导体，冷凝端定位在液体不可渗透的容器内; 液体不可渗透容器中的第一孔，具有允许该组蒸发器盘管穿过该孔的尺寸，形状和位置的第一孔; 所述液体不可渗透容器中的第二孔，所述第二孔包括与所述单向导热体的外表面配合的尺寸，形状和位置的内表面; 以及基本上形成与单向导热体的蒸发端热接触的存储区域的一个或多个壁。
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公开(公告)号：WO2016200775A1
公开(公告)日：2016-12-15
申请号：PCT/US2016/036157
申请日：2016-06-07
Applicant: TOKITAE LLC
Inventor： CHOU, Fong-Li , ECKHOFF, Philip A. , FOWLER, Lawrence Morgan , LIU, Shieng , NATARAJAN, Krishnan , PETERSON, Nels R. , WOOD, Lowell L., Jr.
CPC classification number: A61J1/16 , A61J1/1406 , A61J2205/30 , B65B5/045 , B65B5/06 , B65B5/067 , B65B31/00 , B65B51/10 , B65B51/146 , B65B61/04 , B65B63/04 , B65B2220/16
Abstract: Methods and devices are described for packaging a multi-monodose container including covering a molded structure with a hermetically-sealable overwrap, the molded structure including a first portion and a second portion, the first portion including a row of interconnected monodose pharmaceutical vials, each of the interconnected monodose pharmaceutical vials enclosing a dose of at least one pharmaceutical agent, the second portion affixed to the first portion and including a textured surface pattern positioned to direct gas flow between the first portion and a region adjacent to the second portion; evacuating at least a portion of air from around the molded structure, the evacuated air at least partially flowing over the textured surface pattern of the second portion; forming a hermetic seal around the row of interconnected monodose pharmaceutical vials; and separating the second portion of the molded structure from the first portion of the molded structure.
Abstract translation: 描述了用于包装多单体容器的方法和装置，包括用可密封的外包装覆盖模制结构，所述模制结构包括第一部分和第二部分，所述第一部分包括一排互连的单糖药物小瓶，每个 所述相互连接的单糖药瓶包围剂量的至少一种药剂，所述第二部分固定在所述第一部分上，并且包括纹理表面图案，其被定位成引导所述第一部分与邻近所述第二部分的区域之间的气流; 从模制结构周围抽空至少一部分空气，抽空的空气至少部分地流过第二部分的纹理表面图案; 围绕相互连接的单糖药瓶的一排形成气密密封; 以及将模制结构的第二部分与模制结构的第一部分分开。
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公开(公告)号：WO2016022681A1
公开(公告)日：2016-02-11
申请号：PCT/US2015/043808
申请日：2015-08-05
Applicant: TOKITAE LLC
Inventor： CHOU, Fong-Li , ECKHOFF, Philip A. , FOWLER, Lawrence Morgan , LARUSSON, Fridrik , LIU, Shieng , PETERSON, Nels R. , TEGREENE, Clarence T. , WOOD, Lowell L., Jr.
CPC classification number: F25D16/00 , A61J1/00 , F25B25/02 , F25D2400/02
Abstract: In some embodiments, a medicinal storage container includes: a desiccant unit including external walls forming a gas-impermeable barrier around an interior desiccant region and including an aperture; a heating element; a controller operably attached to the heating element; a cooling unit; a compressor system including at least one evaporator coil unit, the compressor operably connected to the controller; a vapor conduit, the vapor conduit attached to a the desiccant unit at a first end, the vapor conduit attached to the evaporative cooling unit at a second end, the vapor conduit forming an internal, gas-impermeable passageway between the desiccant unit and the cooling unit; a vapor control unit attached to the vapor conduit and operably attached to the controller; and a medicinal storage unit including external walls encircling a medicinal storage region including a temperature sensor operably connected to the controller.
Abstract translation: 在一些实施方案中，药物储存容器包括：干燥剂单元，其包括在内部干燥剂区域周围形成气体不可渗透屏障并包括孔的外壁; 加热元件; 可操作地连接到加热元件的控制器; 冷却单元; 压缩机系统，包括至少一个蒸发器盘管单元，所述压缩机可操作地连接到所述控制器; 蒸汽导管，在第一端处附接到干燥剂单元的蒸汽导管，在第二端处附接到蒸发冷却单元的蒸汽导管，蒸汽导管在干燥剂单元和冷却剂之间形成内部不透气通道 单元; 蒸汽控制单元，其连接到蒸汽管道并可操作地附接到控制器; 以及医疗储存单元，其包括围绕包括可操作地连接到所述控制器的温度传感器的医疗储存区域的外壁。
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Patent Agency Ranking
公开(公告)号：WO2015195736A1
公开(公告)日：2015-12-23
申请号：PCT/US2015/036129
申请日：2015-06-17
Applicant: TOKITAE LLC
Inventor： BOOMGARD, John , CHOU, Fong-Li , ECKHOFF, Philip A. , LARUSSON, Fridrik , SHIENG, Liu , NATARAJAN, Krishnan , PETERSON, Nels R. , WOOD, Lowell L., Jr.
IPC: A61J1/00
CPC classification number: A61J1/16 , A61J1/065 , A61J1/1406 , A61J1/1412 , A61J2205/10 , A61J2205/30 , A61J2205/60 , B65D1/095 , B65D21/0201
Abstract: In some embodiments, an affixed group of pharmaceutical vials with frangible connectors includes: a plurality of pharmaceutical vials arranged as a group of pharmaceutical vials, each of the plurality of pharmaceutical vials shaped and positioned to minimize a total volume of the group of pharmaceutical vials, each of the pharmaceutical vials including at least one external side with a surface configured to reversibly mate with a corresponding external side and a surface of an adjacent pharmaceutical vial; and a plurality of frangible connectors, wherein at least one frangible connector is affixed to the surface of at least two of the plurality of pharmaceutical vials within the group of pharmaceutical vials, and at least one frangible connector is affixed to each of the plurality of pharmaceutical vials.
Abstract translation: 在一些实施方案中，具有易碎连接器的固定的药物小瓶组包括：多个药物小瓶，其布置成一组药物小瓶，所述多个药物小瓶中的每一个成形并定位成使得该组药瓶的总体积最小化， 每个药瓶包括至少一个外表面，其表面被配置为可逆地与相应的药物瓶的相应外侧和表面配合; 以及多个易碎连接器，其中至少一个易碎连接器固定到药物小瓶组内的多个药物小瓶中的至少两个的表面上，并且至少一个易碎连接器固定到多个药物 小瓶。
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公开(公告)号：WO2014160833A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/031965
申请日：2014-03-27
Applicant: TOKITAE LLC
Inventor： ECKHOFF, Philip A. , PETERSON, Nels R. , TEGREENE, Clarence T. , WOOD, Lowell L., Jr.
CPC classification number: F28C3/08 , F25B17/08 , F25B49/046
Abstract: In some embodiments, a portable cooling unit for use with a storage container includes: a desiccant unit including at least one exterior wall defining an interior desiccant region, wherein the interior desiccant region is sealed from gas transfer between the interior desiccant region and a region external to the cooling unit; an evaporative cooling unit including at least one exterior wall defining an interior evaporative region, wherein the interior evaporative region is sealed from gas transfer between the interior evaporative region and the region external to the cooling unit; a vapor conduit including a first and a second end, the vapor conduit attached to the desiccant unit at the first end, the vapor conduit attached to the evaporative cooling unit at the second end, the vapor conduit forming a passageway between the interior desiccant region and the interior evaporative region; and a vapor control unit attached to the vapor conduit.
Abstract translation: 在一些实施例中，用于与存储容器一起使用的便携式冷却单元包括：干燥剂单元，其包括限定内部干燥剂区域的至少一个外壁，其中内部干燥剂区域与内部干燥剂区域和外部区域之间的气体传递密封 到冷却单元; 蒸发冷却单元，其包括限定内部蒸发区域的至少一个外壁，其中所述内部蒸发区域与所述内部蒸发区域和所述冷却单元外部的区域之间的气体传递密封; 包括第一端和第二端的蒸汽导管，在第一端处连接到干燥剂单元的蒸汽导管，在第二端处附接到蒸发冷却单元的蒸汽导管，蒸汽导管在内部干燥剂区域和 内部蒸发区; 以及附接到蒸汽管道的蒸汽控制单元。
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公开(公告)号：WO2017100408A1
公开(公告)日：2017-06-15
申请号：PCT/US2016/065534
申请日：2016-12-08
Applicant: TOKITAE LLC
Inventor： CHOU, Fong-Li , ECKHOFF, Philip A. , FOWLER, Lawrence Morgan , LIU, Shieng , NATARAJAN, Krishnan , PETERSON, Nels R. , WOOD, Lowell L., Jr.
CPC classification number: A61J1/18 , A61J1/067 , A61J1/1481 , A61J2200/70 , A61J2200/72 , B65B5/06 , B65B31/048 , B65B63/04
Abstract: Methods are described for packaging a foldable container including covering a multi-monodose container in an expanded configuration with a hermetically-sealable overwrap, the multi-monodose container including a row of interconnected monodose pharmaceutical vials, each of the monodose pharmaceutical vials enclosing at least one pharmaceutical agent, the interconnected monodose pharmaceutical vials connected to one another by one or more articulating joints sufficiently flexible to form a folded configuration of the multi-monodose container; exerting a force on at least one of the monodose pharmaceutical vials; bending the one or more articulating joints to form the folded configuration of the multi-monodose container in response to the exerted force; and sealing the hermetically-sealable overwrap to form a hermetic seal around the folded configuration of the multi-monodose container.
Abstract translation: 描述了用于包装可折叠容器的方法，所述方法包括用可密封外包装覆盖处于展开构型的多单一剂量容器，所述多单一剂量容器包括一排相互连接的单剂药品小瓶，每一个 所述单剂药物小瓶包封至少一种药剂，所述互连的单剂药剂小瓶通过一个或多个铰接接头相互连接，所述一个或多个铰接接头足够柔性以形成所述多单剂容器的折叠构造; 对至少一个单剂量药瓶施加作用力; 响应于所施加的力而弯曲所述一个或多个铰接接头以形成所述多单剂容器的折叠构造; 并且密封可密封的外包裹物以围绕多单体容器的折叠构型形成气密密封。
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公开(公告)号：WO2017066412A2
公开(公告)日：2017-04-20
申请号：PCT/US2016/056785
申请日：2016-10-13
Applicant: TOKITAE LLC
Inventor： CHOU, Fong-Li , ECKHOFF, Philip A. , FOWLER, Lawrence Morgan , LIU, Shieng , MAIER-LAXHUBER, Peter K. , PETERSON, Nels R. , SCHMIDT, Ralf W. , TEGREENE, Clarence T. , WOOD, Lowell L., Jr. , WÖRZ, Reinier M. , YAGER, David J.
CPC classification number: F25D7/00 , F25D2400/12
Abstract: Portage storage containers including controlled evaporative cooling systems are described herein. In some embodiments, a portable container including an integral controlled evaporative cooling system includes: a storage region, an evaporative region adjacent to the storage region, a desiccant region adjacent to the outside of the container, and an insulation region positioned between the evaporative region and the desiccant region. A vapor conduit with an attached vapor control unit has a first end within the evaporative region and a second end within the desiccant region. In some embodiments, the controlled evaporative cooling systems are positioned in a radial configuration within the portable container.
Abstract translation: 这里描述了包括受控蒸发冷却系统的Portage储存容器。 在一些实施例中，包括整体式受控蒸发冷却系统的便携式容器包括：储存区域，与储存区域相邻的蒸发区域，与容器外部相邻的干燥剂区域以及位于蒸发区域与蒸发区域之间的绝热区域 干燥剂区域。 具有附接的蒸气控制单元的蒸气导管具有在蒸发区域内的第一端和在干燥剂区域内的第二端。 在一些实施例中，受控蒸发冷却系统以便携式容器内的径向配置定位。
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10.发明申请
公开(公告)号：WO2015116555A1
公开(公告)日：2015-08-06
申请号：PCT/US2015/012995
申请日：2015-01-27
Applicant: TOKITAE LLC
Inventor： ECKHOFF, Philip A. , ISHIKAWA, Muriel Y. , PETERSON, Nels R. , WOOD, Lowell L., Jr. , WOOD, Victoria Y.H.
CPC classification number: G01L19/08 , A61J1/065 , A61J1/1406 , A61J1/18 , A61J1/201 , A61J1/2096 , A61J2200/70 , B65B3/003 , B65B7/2821 , B65B31/042 , B65B31/08 , B65B51/10 , B65B57/00
Abstract: Methods, systems, and devices are described for calculating a push pressure for a pharmaceutical vial with a syringe, the method including accepting data regarding at least one parameter of the pharmaceutical vial, at least one parameter of a vial cap with a seal, at least one parameter of the syringe, and a single dose volume of a liquid pharmaceutical; calculating a volume of headspace over the liquid pharmaceutical with a computing device; calculating an ejection pressure based on the single dose volume of the liquid pharmaceutical and the volume of headspace; calculating a motive pressure based on a static force and a cross-sectional area of the syringe; defining the push pressure as the greater of the ejection pressure or the motive pressure; and reporting the push pressure to a user. The method further includes calculating a molar amount of inert gas needed in the pharmaceutical vial to generate the calculated push pressure.
Abstract translation: 描述了用于计算具有注射器的药物瓶的推压的方法，系统和装置，所述方法包括接受关于药物瓶的至少一个参数的数据，至少一个具有密封的小瓶盖的参数 注射器的一个参数和单剂量的液体药物; 用计算装置计算液体药物上的顶空体积; 基于液体药物的单剂量体积和顶部空间体积来计算喷射压力; 基于注射器的静力和横截面面积来计算运动压力; 将推压力定义为喷射压力或动力压力的较大值; 并向用户报告推压。 该方法还包括计算药物小瓶中所需的惰性气体的摩尔量以产生计算出的推压。
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