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    USE OF ANGIOTENSIN ANALOGUES FOR PROMOTING ERYTHROPOIESIS
    1.
    发明申请
    USE OF ANGIOTENSIN ANALOGUES FOR PROMOTING ERYTHROPOIESIS 审中-公开
    使用血管紧张素类似物促进红细胞生成

    公开(公告)号：WO9940106A3

    公开(公告)日：1999-09-23

    申请号：PCT/US9902648

    申请日：1999-02-08

    Applicant: UNIV SOUTHERN CALIFORNIA

    Inventor： RODGERS KATHLEEN E ,  DIZEREGA GERE

    IPC: A61K38/00 ,  A61K38/08 ,  A61K38/22 ,  A61P7/06 ,  C07K7/06 ,  C12N5/078 ,  C07K7/14 ,  C12N5/00

    CPC classification number: A61K38/085 ,  C12N5/0644 ,  C12N2501/32

    Abstract: The present invention provides methods, compounds, pharmaceutical compositions, and kits for the augmentation of erythropoiesis by potentiating erythropoietin-induced differentiation with angiotensinogen, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists as a therapeutic adjunct. The method is useful for the treatment of congenital or acquired aplastic or hypoplastic anemia associated with chronic renal failure, end-stage renal disease, renal transplantation, cancer, AIDS, chemotherapy, radiotherapy, bone marrow transplantation and chronic diseases.

    Abstract translation: 本发明提供了通过用血管紧张素原，血管紧张素I（AI），AI类似物，AI片段及其类似物，血管紧张素II类似物，AII片段或类似物增强红细胞生成素诱导的分化来增加红细胞生成的方法，化合物，药物组合物和试剂盒 或AII AT2型2受体激动剂作为治疗辅助剂。 该方法可用于治疗与慢性肾功能衰竭，终末期肾病，肾移植，癌症，艾滋病，化疗，放疗，骨髓移植和慢性疾病相关的先天性或获得性再发性或发育不全的贫血。

    METHOD OF PROMOTING HEPATIC CELL PROLIFERATION
    6.
    发明申请
    METHOD OF PROMOTING HEPATIC CELL PROLIFERATION 审中-公开
    促进肝细胞增殖的方法

    公开(公告)号：WO9939743A3

    公开(公告)日：1999-09-30

    申请号：PCT/US9902618

    申请日：1999-02-08

    Applicant: UNIV SOUTHERN CALIFORNIA ,  RODGERS KATHLEEN E ,  DIZEREGA GERE

    Inventor： RODGERS KATHLEEN E ,  DIZEREGA GERE

    IPC: A61K38/08 ,  C12N5/071 ,  C12N5/08

    CPC classification number: C12N5/067 ,  A61K38/085 ,  C12N2501/32

    Abstract: The present invention provides methods, improved cell culture medium and kits for promoting hepatic cell proliferation and differentiation by growth in the presence of angiotensinogen, AI, AI anoalogues, and/or AI fragments and analogues thereof, AII analogues, AII fragments or analogues thereof, and/or AII AT2 type 2 receptor agonists, either alone or in combination with other growth factors and cytokines.

    Abstract translation: 本发明提供了在存在血管紧张肽原，AI，AI类和/或其片段及类似物，AII类似物，AII片段或其类似物的情况下通过生长促进肝细胞增殖和分化的方法，改良的细胞培养基和试剂盒， 和/或AII AT2 2型受体激动剂，单独或与其他生长因子和细胞因子组合。

    METHODS FOR PROMOTING DENDRITIC CELL PROLIFERATION OR DIFFERENTIATION
    9.
    发明申请
    METHODS FOR PROMOTING DENDRITIC CELL PROLIFERATION OR DIFFERENTIATION 审中-公开
    促进细胞增殖或分化的方法

    公开(公告)号：WO0206308A3

    公开(公告)日：2003-02-27

    申请号：PCT/US0121587

    申请日：2001-07-09

    Applicant: UNIV SOUTHERN CALIFORNIA ,  RODGERS KATHLEEN E ,  DIZEREGA GERE

    Inventor： RODGERS KATHLEEN E ,  DIZEREGA GERE

    IPC: A61K38/00 ,  A61K38/19 ,  A61P35/00 ,  C07K7/14 ,  C12N5/0784 ,  A61K38/08 ,  A61K39/00

    CPC classification number: C12N5/0639 ,  A61K38/00 ,  A61K38/19 ,  C07K7/14 ,  C12N2501/32 ,  A61K2300/00

    Abstract: The present invention provides methods, pharmaceutical compositions, and kits for promoting dendritic cell proliferation and differentiation, through the use one or more or renin, angiotensinogen converting enzyme (ACE), neutral endopeptidase, angiotensin I (AI), AI analogues, AI fragments and analogues thereof, angiotensin II (AII), AII analogues, AII fragments or analogues thereof or AII AT2 type 2 receptor agonists, angiotensin converting enzyme inhibitors (ACE inhibitors). Such methods are useful, for example, for promoting tumor vaccine production, or for improving the efficacy of a tumor vaccine.

    Abstract translation: 本发明通过使用一种或多种或肾素，血管紧张素原转化酶（ACE），中性内肽酶，血管紧张素I（AI），AI类似物，AI片段和/或其衍生物，提供用于促进树突细胞增殖和分化的方法，药物组合物和试剂盒 其类似物，血管紧张素II（AII），AII类似物，AII片段或其类似物或AIIAT2型2受体激动剂，血管紧张素转换酶抑制剂（ACE抑制剂）。 这样的方法可用于例如促进肿瘤疫苗生产或用于改善肿瘤疫苗的功效。

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