公开(公告)号：WO2012075447A2

公开(公告)日：2012-06-07

申请号：PCT/US2011/063159

申请日：2011-12-02

申请人： WARSAW ORTHOPEDIC, INC. ,  GRAY, Jonathan K. ,  MARX, Jeffrey C. ,  MCKAY, William ,  ROY, Josee ,  CLAY, Danielle ,  WILSEY, Jared T. ,  ZANELLA, John Meyers

发明人： GRAY, Jonathan K. ,  MARX, Jeffrey C. ,  MCKAY, William ,  ROY, Josee ,  CLAY, Danielle ,  WILSEY, Jared T. ,  ZANELLA, John Meyers

IPC分类号： A61K9/22 ,  A61K31/445 ,  A61K31/415

CPC分类号： A61K9/0024 ,  A61K31/167 ,  A61K31/4168 ,  A61K31/445 ,  A61K47/34 ,  A61K2300/00

摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release bupivacaine or lidocaine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.

摘要翻译： 提供长时间有效的疼痛治疗。 通过给予有效量的立即释放布比卡因或利多卡因和在目标部位或其附近的缓释可乐定，可以缓解由不同来源引起的疼痛，包括但不限于脊椎间盘突出症（即坐骨神经痛），导丝，狭窄 ，椎间盘源性背痛和关节痛。 当在生物可降解聚合物内提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解剂可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天或更长。

公开(公告)号：WO2012148570A1

公开(公告)日：2012-11-01

申请号：PCT/US2012/027464

申请日：2012-03-02

申请人： WARSAW ORTHOPEDIC, INC. ,  BIGGS, Danielle L. ,  WILSEY, Jared T.

发明人： BIGGS, Danielle L. ,  WILSEY, Jared T.

IPC分类号： A61L27/14 ,  C08L101/16 ,  A61P17/02

CPC分类号： A61K31/58 ,  A61K38/27 ,  A61K38/28 ,  A61K38/30 ,  A61L26/0066 ,  A61L26/009 ,  A61L2300/222 ,  A61L2300/414 ,  A61L2300/43 ,  A61L2300/604

摘要： Improved medical devices and methods are provided comprising an anabolic agent for wound healing. These improved medical devices and methods can enhance wound healing in wounds from cuts, abrasions, lesions, burns including sunburn, surgical incisions, pressure ulcers, diabetic ulcers, traumatic wounds, or other injuries or maladies, which can be chronic or non-chronic in origin. In some embodiments, the medical device comprises a drug depot that releases the anabolic agent over at least 3 days to enhance wound healing.

摘要翻译： 提供了改进的医疗装置和方法，其包括用于伤口愈合的合成代谢剂。 这些改进的医疗装置和方法可以增强切口，擦伤，损伤，烧伤，包括晒伤，手术切口，压力性溃疡，糖尿病性溃疡，创伤性伤口或其他可能是慢性或非慢性的损伤或疾病的伤口的伤口愈合 起源。 在一些实施方案中，医疗装置包括在至少3天内释放合成代谢剂以增强伤口愈合的药物贮库。

公开(公告)号：WO2012075451A2

公开(公告)日：2012-06-07

申请号：PCT/US2011/063164

申请日：2011-12-02

申请人： WARSAW ORTHOPEDIC, INC. ,  WILSEY, Jared T. ,  BIGGS, Danielle L. ,  MARX, Jeffrey C. ,  MCKAY, William ,  ROY, Josee ,  ZANELLA, John Meyers

发明人： WILSEY, Jared T. ,  BIGGS, Danielle L. ,  MARX, Jeffrey C. ,  MCKAY, William ,  ROY, Josee ,  ZANELLA, John Meyers

IPC分类号： A61K9/22 ,  A61K31/415 ,  A61K31/41

CPC分类号： A61K31/195 ,  A61K9/0024 ,  A61K31/4168 ,  A61K31/662 ,  A61K45/06 ,  A61K47/34

摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of clonidine and a gamma-aminobutyric acid compound at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

摘要翻译： 提供长时间有效的疼痛治疗。 通过在靶位点处或附近施用有效量的可乐定和γ-氨基丁酸化合物，可以缓解由各种来源引起的疼痛，包括但不限于脊椎间盘突出症（即坐骨神经痛），导丝理论，狭窄，致畸形 背部疼痛和关节疼痛，以及伴随手术的疼痛。 当在生物可降解聚合物内提供适当的制剂时，这种缓解可以持续至少三天。 在一些实施方案中，缓解剂可以是至少二十五天，至少五十天，至少一百天，至少一百三十五天或至少一百八十天。

公开(公告)号：WO2013126205A1

公开(公告)日：2013-08-29

申请号：PCT/US2013/024717

申请日：2013-02-05

申请人： WARSAW ORTHOPEDIC, INC.

发明人： WILSEY, Jared T.

IPC分类号： A61K47/48 ,  A61K47/30 ,  A61K31/135 ,  A61K31/13 ,  A61P25/24

CPC分类号： A61K31/135 ,  A61K9/0024 ,  A61K31/335 ,  A61K31/381 ,  A61K45/06 ,  A61K2300/00

摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of mixed monoamine reuptake inhibitor locally at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation ( i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least thirty days. In some embodiments, the relief can be for at least at least fifty days, at least one hundred days, at least one hundred and twenty days, at least one hundred and thirty, at least one hundred fifty days or at least one hundred and eighty days.

摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位处或附近局部施用有效量的混合单胺再摄取抑制剂，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和 关节疼痛以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少30天。 在一些实施例中，浮雕可以是至少至少五十天，至少一百天，至少一百二十天，至少一百三十，至少一百五十天，或至少一百八十 天。

公开(公告)号：WO2012075440A4

公开(公告)日：2012-06-07

申请号：PCT/US2011/063147

申请日：2011-12-02

申请人： WARSAW ORTHOPEDIC, INC. ,  WILSEY, Jared T. ,  BIGGS, Danielle L. ,  GRAY, Jonathan K. ,  MARX, Jeffrey C. ,  MCKAY, William ,  ROY, Josee ,  ZANELLA, John Meyers

发明人： WILSEY, Jared T. ,  BIGGS, Danielle L. ,  GRAY, Jonathan K. ,  MARX, Jeffrey C. ,  MCKAY, William ,  ROY, Josee ,  ZANELLA, John Meyers

IPC分类号： A61K9/22

摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release clonidine and a sustained release clonidine at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least three days. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days or longer.