公开(公告)号：WO2013116285A1

公开(公告)日：2013-08-08

申请号：PCT/US2013/023771

申请日：2013-01-30

申请人： WATERS TECHNOLOGIES CORPORATION

发明人： GERHARDT, Geoff, C. ,  FADGEN, Keith, Edward ,  MICHIENZI, Joseph, D. ,  BUNNER, Bernard

IPC分类号： B01D15/08

CPC分类号： G01N30/38 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/567 ,  B01L2200/0689 ,  B01L2400/0622 ,  B01L2400/0644 ,  F04D15/00 ,  F04D29/086 ,  F16K99/0013 ,  G01N30/20 ,  G01N2030/202

摘要： A system (e.g., a chromatography system) includes a rotor, a microfluidic device, a rotor driver, a clamping mechanism, and control electronics. The rotor defines a plurality of first fluid-conveying features. The micro fluidic device defines one or more channels and a plurality of second fluid-conveying features, in fluid communication with the one or more channels. The rotor driver is coupled to the rotor and is configured to rotate the rotor, relative to the microfluidic device, between a first position and a second position such that, in each of the positions, at least one of the first fluid-conveying features cooperates with at least one of the one or more channels to provide for fluid communication therebetween. The clamping mechanism is operable to provide a sealing force to establish a fluid-tight seal between the rotor and the microfluidic device.

摘要翻译： 系统（例如，色谱系统）包括转子，微流体装置，转子驱动器，夹紧机构和控制电子装置。 转子限定多个第一流体输送特征。 微流体装置限定与一个或多个通道流体连通的一个或多个通道和多个第二流体输送特征。 转子驱动器联接到转子并且构造成使转子相对于微流体装置在第一位置和第二位置之间旋转，使得在每个位置中，第一流体输送特征中的至少一个配合 具有一个或多个通道中的至少一个以提供其间的流体连通。 夹紧机构可操作以提供密封力，以在转子和微流体装置之间建立流体密封的密封。

公开(公告)号：WO2011075568A1

公开(公告)日：2011-06-23

申请号：PCT/US2010/060729

申请日：2010-12-16

申请人： WATERS TECHNOLOGIES CORPORATION ,  GERHARDT, Geoff, C.

发明人： GERHARDT, Geoff, C.

IPC分类号： B01D21/24

CPC分类号： G01N30/32 ,  G01F1/00 ,  G01F1/6845 ,  G01N11/00 ,  G01N2030/324

摘要： One aspect of the invention provides a flow sensing apparatus for sensing fluid flow in a nano-scale high-performance liquid chromatography apparatus. The flow sensing apparatus includes: a fluid channel that allows a fluid to flow in a first direction; a first infrared sensor arranged at a first position along the fluid channel such that it senses a temperature of the fluid; a second infrared sensor arranged at a second position along the fluid channel and separated from the first sensor by a predetermined distance along the fluid channel; and a heating element arranged between the first and second infrared sensors. The heating element is equally spaced from the first and second infrared sensors.

摘要翻译： 本发明的一个方面提供一种用于感测纳米级高效液相色谱装置中的流体流动的流量检测装置。 流量检测装置包括：允许流体沿第一方向流动的流体通道; 布置在沿着流体通道的第一位置处的第一红外传感器，使得其感测流体的温度; 布置在沿着流体通道的第二位置并沿着流体通道与第一传感器分离预定距离的第二红外传感器; 以及布置在第一和第二红外传感器之间的加热元件。 加热元件与第一和第二红外传感器相等间隔。

公开(公告)号：WO2019200388A1

公开(公告)日：2019-10-17

申请号：PCT/US2019/027499

申请日：2019-04-15

申请人： WATERS TECHNOLOGIES CORPORATION

发明人： FOGWILL, Michael, O. ,  DEVLIN, Curt ,  DOURDEVILLE, Theodore, A. ,  FAIRCHILD, Jacob, N. ,  GERHARDT, Geoff, C. ,  LEVEILLE, Wade, P. ,  MICHIENZI, Joseph, D. ,  MUSACCHIO, Jeffrey

IPC分类号： G01N30/72 ,  H01J49/16

摘要： Techniques and apparatus for ion source devices with minimized post- column volumes are described. In one embodiment, for example, an ion source assembly (330) may include a chromatography column (334) in fluid communication with an ion source device (336), the chromatography column (334) arranged within a minimum distance of the ion source (336), the minimum distance comprising between about 60 mm and about 150 mm.

公开(公告)号：WO2011075571A1

公开(公告)日：2011-06-23

申请号：PCT/US2010/060736

申请日：2010-12-16

申请人： WATERS TECHNOLOGIES CORPORATION ,  GERHARDT, Geoff, C.

发明人： GERHARDT, Geoff, C.

IPC分类号： C02F1/00

CPC分类号： G01N30/32 ,  G01F1/00 ,  G01F1/6845 ,  G01N11/00 ,  G01N2030/324

摘要： One aspect of the invention provides a flow sensing apparatus including: a fluid channel that allows a fluid to flow in a first direction; a first temperature sensor arranged at a first position along the fluid channel; a second temperature sensor arranged at a second position along the fluid channel and separated from the first sensor by a predetermined distance along the fluid channel; a heating element arranged between the first and second thermoelectric sensors, the heating element being substantially equally spaced from the first and second thermoelectric sensors; a heating element temperature sensor for sensing a temperature of the heating element; and a control device configured to maintain the heating element at a substantially uniform temperature.

摘要翻译： 本发明的一个方面提供了一种流量检测装置，包括：允许流体沿第一方向流动的流体通道; 布置在沿着流体通道的第一位置的第一温度传感器; 第二温度传感器，布置在沿着流体通道的第二位置处，并沿着流体通道与第一传感器分离预定距离; 布置在所述第一和第二热电传感器之间的加热元件，所述加热元件与所述第一和第二热电传感器基本等距离; 用于感测加热元件的温度的加热元件温度传感器; 以及配置成将加热元件保持在基本均匀的温度的控制装置。

公开(公告)号：WO2010151440A1

公开(公告)日：2010-12-29

申请号：PCT/US2010/038288

申请日：2010-06-11

申请人： WATERS TECHNOLOGIES CORPORATION ,  GERHARDT, Geoff, C. ,  NEUE, Uwe, Dieter ,  JEANNOTTE, Anthony, C. ,  DOURDEVILLE, Theodore, A.

发明人： GERHARDT, Geoff, C. ,  NEUE, Uwe, Dieter ,  JEANNOTTE, Anthony, C. ,  DOURDEVILLE, Theodore, A.

IPC分类号： B01D15/08

CPC分类号： G01N30/20 ,  G01N2030/202 ,  G01N2030/347 ,  G01N2030/6013 ,  G01N30/6095

摘要： A chromatography apparatus includes a sample-delivery patterned substrate and a tube-based separation column directly connected to an outlet port of the patterned substrate. The patterned substrate includes an injector valve connected to the outlet port.

摘要翻译： 色谱装置包括样品传送图案化衬底和直接连接到图案化衬底的出口的基于管的分离柱。 图案化衬底包括连接到出口的喷射阀。

公开(公告)号：WO2011153122A2

公开(公告)日：2011-12-08

申请号：PCT/US2011/038494

申请日：2011-05-31

申请人： WATERS TECHNOLOGIES CORPORATION ,  JUNG, Moon Chul ,  BOUVIER, Edouard S. P. ,  GERHARDT, Geoff, C.

发明人： JUNG, Moon Chul ,  BOUVIER, Edouard S. P. ,  GERHARDT, Geoff, C.

CPC分类号： B01L3/5023 ,  B01L2300/0822 ,  G01N1/405 ,  G01N30/06 ,  G01N30/16 ,  G01N2001/288 ,  G01N2001/4088 ,  G01N2030/009 ,  G01N2030/062

摘要： Described is a device for collecting a fluid sample, such as a biological fluid sample. The device includes a planar collection substrate having an absorbent material. The planar collection substrate includes an impermeable region and a sample collection region. The impermeable region is impermeable to the fluid sample and is embedded in the planar collection substrate in a spatial pattern. The sample collection region is in an area excluded from the spatial pattern and has a shape and a size defined by the spatial pattern. The sample collection region is configured to receive a known volume of the fluid sample. In an alternative form, the device includes a sample collection element disposed in an impermeable planar holder and, in another alternative form, the device includes an absorbent material disposed inside an impermeable tube wall.

摘要翻译： 描述了用于收集诸如生物流体样品的流体样品的装置。 该装置包括具有吸收材料的平面收集基板。 平面收集基板包括不可渗透区域和样品收集区域。 不渗透区域对于流体样品是不可渗透的，并以空间图案嵌入在平面收集基板中。 样本收集区域处于从空间图案排除的区域中，并且具有由空间图案定义的形状和尺寸。 样品收集区域被配置为接收已知体积的流体样品。 在替代形式中，该装置包括设置在不可渗透的平面保持器中的样品收集元件，并且在另一替代形式中，该装置包括设置在不可渗透管壁内部的吸收材料。

公开(公告)号：WO2009111431A2

公开(公告)日：2009-09-11

申请号：PCT/US2009/035811

申请日：2009-03-03

申请人： WATERS TECHNOLOGIES CORPORATION ,  BUNNER, Bernard ,  GERHARDT, Geoff, C. ,  JARRELL, Joseph, A.

发明人： BUNNER, Bernard ,  GERHARDT, Geoff, C. ,  JARRELL, Joseph, A.

IPC分类号： G01N21/05

CPC分类号： H01J49/167 ,  B01L3/0268 ,  B01L3/502792 ,  B01L2200/026 ,  B01L2300/0819 ,  B01L2300/089 ,  B01L2400/0427 ,  B03C5/024 ,  B03C2201/26 ,  G01N30/06 ,  G01N30/20 ,  G01N2030/201

摘要： Described are techniques for use in connection with analyzing a droplet. One or more more droplets of a sample are formed on a surface of a digital microfluidic device. The droplets are manipulated to perform processing using said one or more droplets generating one or more resulting droplets. The one or more resulting droplets may be transferred from the microfluidic device to another device for analysis. The one or more droplets may also be provided to the digital microfluidic device from yet another device or analysis instrument.

摘要翻译： 描述了用于结合分析液滴的技术。 数字微流体装置的表面上形成一个或多个更多的样品液滴。 使用所述一个或多个液滴产生一个或多个产生的液滴来操纵液滴以执行处理。 一个或多个产生的液滴可以从微流体装置转移到另一个装置进行分析。 一个或多个液滴也可以从另一个装置或分析仪器提供给数字微流体装置。

公开(公告)号：WO2013028774A1

公开(公告)日：2013-02-28

申请号：PCT/US2012/051892

申请日：2012-08-22

申请人： WATERS TECHNOLOGIES CORPORATION ,  MURPHY, James, P. ,  TOMANY, Michael, J. ,  MICHIENZI, Joseph, D. ,  RAINVILLE, Paul ,  PLUMB, Robert, S. ,  GERHARDT, Geoff, C. ,  JUNG, Moon Chul

发明人： MURPHY, James, P. ,  TOMANY, Michael, J. ,  MICHIENZI, Joseph, D. ,  RAINVILLE, Paul ,  PLUMB, Robert, S. ,  GERHARDT, Geoff, C. ,  JUNG, Moon Chul

IPC分类号： G01N33/00 ,  G01N30/02 ,  G01N21/00

CPC分类号： G01N30/06 ,  B01L3/502715 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/1827 ,  G01N30/16 ,  G01N30/6095 ,  G01N30/88 ,  G01N33/49 ,  G01N2001/383 ,  G01N2030/009 ,  G01N2030/062

摘要： An apparatus for use in a chromatography system includes a microfluidic substrate having a fluidic channel configured as an analytical chromatographic column and a fluidic port on one side of the microfluidic substrate. The fluidic port opens at a head end of the analytical chromatographic column. A dried blood spot (DBS) collection device holds one or more dried biological samples. The DBS collection device is directly coupled to the microfluidic substrate whereby one of the biological samples is placed into fluidic communication with the fluidic channel of the microfluidic substrate and an extraction of that biological sample flows toward the head end of the analytical chromatographic column. A diluent source fluidically coupled to the fluidic port supplies a solvent to the head end of the analytical column to dilute the extracted biological sample before the biological sample flows into the analytical chromatographic column.

摘要翻译： 用于色谱系统的装置包括具有配置为分析色谱柱的流体通道和在微流体衬底的一侧上的流体端口的微流体衬底。 流体端口在分析色谱柱的头端打开。 干血斑（DBS）收集装置容纳一个或多个干燥的生物样品。 DBS收集装置直接耦合到微流体底物，其中一个生物样品被放置成与微流体底物的流体通道流体连通，并且该生物样品的提取流向分析色谱柱的头端。 流体耦合到流体端口的稀释剂源将溶剂提供到分析柱的头端，以在生物样品流入分析色谱柱之前稀释提取的生物样品。

公开(公告)号：WO2012125381A1

公开(公告)日：2012-09-20

申请号：PCT/US2012/028155

申请日：2012-03-08

申请人： WATERS TECHNOLOGIES CORPORATION ,  GERHARDT, Geoff, C. ,  FADGEN, Keith

发明人： GERHARDT, Geoff, C. ,  FADGEN, Keith

IPC分类号： H01J49/00

CPC分类号： H01J49/0009 ,  H01J49/00 ,  H01J49/04

摘要： An electrokinetic pump can be used to deliver calibrant ("lock mass") ions to a mass spectrometer for calibration of a mass spectrometry system. Electrokinetically controlled calibrant delivery can help to eliminate the need for the more cumbersome mechanisms that are often used for ion delivery. In addition, electrokinetically controlled calibrant delivery can provide for a more user- friendly system in which a calibrant solution can be packaged into a disposable cartridge. Furthermore, when implemented in a microfluidic format, electrokinetically controlled calibrant delivery can be coupled with an electrokinetically controlled separation system, such as capillary electrophoresis (CE), to allow efficient solid-state switching between analytical and calibrant sprays.

摘要翻译： 可以使用电动泵将校准物（“锁定质量”）离子输送到质谱仪用于校准质谱系统。 电动控制的校准物输送可以帮助消除对经常用于离子传递的更繁琐的机制的需要。 此外，电动控制的校准物输送可以提供更加用户友好的系统，其中校准液可以被包装到一次性盒中。 此外，当以微流体形式实施时，电动控制的校准物输送可与电动控制的分离系统（例如毛细管电泳（CE））结合，以允许分析和校准喷雾之间的有效的固态切换。

公开(公告)号：WO2012027632A1

公开(公告)日：2012-03-01

申请号：PCT/US2011/049275

申请日：2011-08-26

申请人： WATERS TECHNOLOGIES CORPORATION ,  GERHARDT, Geoff, C. ,  FADGEN, Keith

发明人： GERHARDT, Geoff, C. ,  FADGEN, Keith

IPC分类号： F16K11/074

CPC分类号： F16K11/00 ,  F16K11/0743 ,  Y10T137/0318 ,  Y10T137/86863

摘要： Variable- volume injection valves include a stator and a rotor. The stator has a first port, a second port, and a contact surface with a groove therein. The first port opens into the stator groove. The rotor has a contact surface with a groove therein. The contact surface of the rotor is urged against the contact surface of the stator such that the rotor groove opposes the stator groove with one end of the rotor groove overlapping the stator groove and the opposite end of the rotor groove overlapping the second port of the stator. The overlapping grooves of the rotor and stator provide a fluidic channel between the first and second ports of the stator. The rotor is movable with respect to the stator in order to vary a length of overlap between their overlapping grooves.

摘要翻译： 可变容积喷射阀包括定子和转子。 定子具有第一端口，第二端口和与其中的凹槽的接触表面。 第一端口通向定子槽。 转子具有与其中的凹槽的接触表面。 转子的接触表面被推靠在定子的接触表面上，使得转子槽与定子槽相对，转子槽的一端与定子槽重叠，转子槽的相对端与定子的第二端重叠 。 转子和定子的重叠槽在定子的第一和第二端口之间提供流体通道。 转子可相对于定子移动，以便改变其重叠槽之间的重叠长度。