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    A MICROFLUIDIC VALVE AND A CHIP OR SYSTEM COMPRISING THE MICROFLUIDIC VALVE
    1.
    发明申请
    A MICROFLUIDIC VALVE AND A CHIP OR SYSTEM COMPRISING THE MICROFLUIDIC VALVE 审中-公开
    微流控阀和包含微流控阀的芯片或系统

    公开(公告)号：WO2017054369A1

    公开(公告)日：2017-04-06

    申请号：PCT/CN2016/000549

    申请日：2016-09-30

    Applicant: CAPITALBIO CORPORATION

    Inventor： WANG, Lei ,  ZHOU, Yao ,  WANG, Hu ,  LIN, Mingxian ,  WANG, Tongjun ,  BAI, Liang ,  HUANG, Guoliang ,  WANG, Dong ,  XING, Wanli

    IPC: F16K99/00

    CPC classification number: F16K99/0013 ,  F16K2099/0082

    Abstract: A microfluidic valve provided herein is configured to mix or capable of mixing a sample and/or a reagent in addition to controlling liquid flow. In one embodiment, the microfluidic valve comprises a rotor (3) and one or more micro-structures (2) that move with the rotation of the rotor (3). In one embodiment, the one or more micro-structures (2) stir and/or mix content in a mixing chamber (5) formed by the rotor (3), a base (1), and a sleeve (4) of the microfluidic valve. A microfluidic chip or chip system comprising one or more of the microfluidic valves, and methods of use, are also provided.

    Abstract translation: 本文提供的微流体阀被配置为混合或能够混合样品和/或试剂以及控制液体流动。 在一个实施例中，微流体阀包括与转子（3）的旋转一起移动的转子（3）和一个或多个微结构（2）。 在一个实施方案中，一个或多个微结构（2）在由转子（3），基底（1）和微流体的套筒（4）形成的混合室（5）中搅拌和/或混合内容物 阀。 还提供了包括一个或多个微流体阀的微流体芯片或芯片系统，以及使用方法。

    MICROFLUIDIC CHIP
    3.
    发明申请
    MICROFLUIDIC CHIP 审中-公开
    MICROFLUIDIC芯片

    公开(公告)号：WO2016059419A3

    公开(公告)日：2016-06-16

    申请号：PCT/GB2015053068

    申请日：2015-10-15

    Applicant: RANDOX LAB LTD

    Inventor： JACKSON STUART ,  CROCKARD MARTIN ,  HASWELL STEVE

    IPC: B01L3/00 ,  F16K99/00

    CPC classification number: B01L3/5027 ,  B01L3/5023 ,  B01L3/502738 ,  B01L2300/0887 ,  B01L2400/0644 ,  F16K99/0001 ,  F16K99/0013 ,  F16K2099/0084

    Abstract: According to the invention there is a microfluidic chip (1) that includes at least two layers (10) forming a stack of layers, each layer of which has at least one flow channel (14); a bore (16) extending through the layers and communicating with a plurality of flow channels; and a valve (20), which has a shaft (22) with a recess (222) in a side of the shaft for fluid to flow through. The shaft is rotatably mounted in the bore, and has a first position in which the recess is aligned with each of at least two flow channels of the plurality of flow channels thereby providing a flow path between said at least two flow channels, and a second position in which the recess is unaligned with at least one of said at least two flow channels the flow path between said at least two flow channels thereby being closed. This allows a fluid flow path between two flow channels to be open and closed by rotation of the shaft so that fluid in the microfluidic chip can be redirected to allow the chip to have greater capability and by using a minimal amount of space on the chip to do so.

    Abstract translation: 根据本发明，提供了一种微流体芯片（1），其包括至少两个层（10），形成层的堆叠，其中每个层具有至少一个流动通道（14）; 孔（16），其延伸穿过所述层并与多个流动通道连通; 和阀门（20），该阀门具有轴（22），该轴（22）在轴的侧部具有用于流体流过的凹部（222）。 所述轴可旋转地安装在所述孔中，并且具有第一位置，在所述第一位置中，所述凹部与所述多个流动通道中的至少两个流动通道中的每个流动通道对准，由此在所述至少两个流动通道之间提供流动路径， 在该位置中，所述凹槽与所述至少两个流动通道中的至少一个流动通道未对齐，从而所述至少两个流动通道之间的流动通道由此被关闭。 这允许两个流动通道之间的流体流动路径通过轴的旋转而打开和关闭，使得微流体芯片中的流体可以被重新引导以允许芯片具有更大的能力并且通过在芯片上使用最小量的空间来 这样做。

    PASSIVE FLUID FLOW REGULATOR
    4.
    发明申请
    PASSIVE FLUID FLOW REGULATOR 审中-公开
    被动流体流量调节器

    公开(公告)号：WO2010020891A1

    公开(公告)日：2010-02-25

    申请号：PCT/IB2009/052775

    申请日：2009-06-26

    Applicant: DEBIOTECH S.A. ,  CHAPPEL, Eric

    Inventor： CHAPPEL, Eric

    IPC: A61M5/168 ,  F15C3/04 ,  A61M5/145 ,  A61M27/00

    CPC classification number: A61M5/16881 ,  A61M5/145 ,  A61M27/006 ,  A61M37/00 ,  A61M2205/0244 ,  F16K99/0001 ,  F16K99/0013 ,  F16K99/0015 ,  F16K99/0026 ,  F16K99/0057 ,  F16K2099/0088 ,  Y10T137/86718 ,  Y10T137/87306

    Abstract: A fluid flow regulator (1) of the passive type is disclosed which has a fluid inlet adapted to be connected to a fluid reservoir and a fluid outlet (13)adapted to be connected to a patient's body. The regulator comprises a rigid substrate (2) and a resilient membrane (3) tightly linked together so as to define a cavity (6) there between which is disconnected to the fluid outlet while the membrane has a first surface (12) opposite the cavity which is connected to the fluid inlet. The membrane has a plurality of through holes (15) contiguous with the cavity,to define a pathway for a fluid from the fluid inlet to the fluid outlet, and is flexible so as to be able to come into contact with the substrate as a fluid applies a sufficient pressure on the first surface. The through holes are arranged such that,when the fluid pressure increases, they close one after the other to increase the regulator fluidic resistance so that a fluid flow rate would be substantially constant as a function of the pressure applied on the first surface within a predefined pressure range.

    Abstract translation: 公开了一种无源型流体流量调节器（1），其具有适于连接到流体储存器的流体入口和适于连接到患者身体的流体出口（13）。 调节器包括刚性基板（2）和紧密连接在一起的弹性膜（3），以便限定一个空腔（6），在该空腔之间与流体出口断开，而膜具有与空腔相对的第一表面（12） 其连接到流体入口。 膜具有多个与空腔邻接的通孔（15），以限定用于流体从流体入口到流体出口的路径，并且是柔性的，以便能够作为流体与基底接触 在第一表面施加足够的压力。 通孔布置成使得当流体压力增加时，它们一个接一个地关闭以增加调节器的流体阻力，使得流体流速基本上恒定，这是在预定义的范围内施加在第一表面上的压力的函数 压力范围。

    MICROFLUIDIC ARRANGEMENT WITH COUPLING DEVICE HAVING A SELECTABLE OPTICAL DETECTION PORTION
    5.
    发明申请
    MICROFLUIDIC ARRANGEMENT WITH COUPLING DEVICE HAVING A SELECTABLE OPTICAL DETECTION PORTION 审中-公开
    具有可选择光学检测部分的耦合器件的微流动装置

    公开(公告)号：WO2006056236A1

    公开(公告)日：2006-06-01

    申请号：PCT/EP2004/053104

    申请日：2004-11-25

    Applicant: AGILENT TECHNOLOGIES, INC. ,  ZIMMERMANN, Hans-Peter ,  CHOIKHET, Konstantin ,  PRECKEL, Tobias

    Inventor： ZIMMERMANN, Hans-Peter ,  CHOIKHET, Konstantin ,  PRECKEL, Tobias

    IPC: B01L3/00

    CPC classification number: G01N21/05 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2400/0644 ,  F16K99/0001 ,  F16K99/0013 ,  F16K2099/0084 ,  G01N2021/0346 ,  Y10T137/8242 ,  Y10T137/8326

    Abstract: A fluidic arrangement for an improved optical detection for a microfluidic device is provided, having a channel adapted to conduct a fluid, and a coupling device (1) having at least two coupling channels, one of which selectable for optical detection without interrupting processes running in the other channel(s). The coupling device is coupled with the fluidic device (2), so that the fluid flows from a channel of the fluidic device (2) into one of the coupling channels. The coupling channel having an optical detection portion (6) is part of a detection lane adapted to detect the fluid flowing therethrough, while the fluid flowing through the coupling channel without an optical detection portion is not influenced by the detecting activity. A vertical axis (a-a) permits turning of the coupling device (1) whereas the microfluidic device (2) is statically arranged. Turning leads to alternation of optical detection lane and an idle lane, enabling to detect the fluid of another lane. A method for performing optical detection of fluids processed in a fluidic device comprising one or multiple channels by use of the fluidic arrangement.

    Abstract translation: 提供了一种用于微流体装置的改进的光学检测的流体装置，其具有适于传导流体的通道和具有至少两个耦合通道的耦合装置（1），其中一个可选择用于光学检测而不中断在 其他频道。 联接装置与流体装置（2）联接，使得流体从流体装置（2）的通道流入耦合通道中的一个。 具有光学检测部分（6）的耦合通道是适于检测流过其中的流体的检测通道的一部分，而没有光学检测部分流过耦合通道的流体不受检测活动的影响。 垂直轴（a-a）允许联接装置（1）的转动，而微流体装置（2）是静态布置的。 转向导致光学检测通道和空闲通道的交替，使得能够检测另一个通道的流体。 一种用于在流体装置中处理的流体进行光学检测的方法，该流体装置包括使用流体装置的一个或多个通道。

    A MICRO VALVE APPARATUS USING MICRO BEAD AND METHOD FOR CONTROLLING THE SAME
    6.
    发明申请
    A MICRO VALVE APPARATUS USING MICRO BEAD AND METHOD FOR CONTROLLING THE SAME 审中-公开
    使用微珠的微型阀装置及其控制方法

    公开(公告)号：WO2002097422A1

    公开(公告)日：2002-12-05

    申请号：PCT/KR2002/001035

    申请日：2002-05-31

    Applicant: ELECTRON-BIO, INC. ,  YOO, Jae-Chern

    Inventor： YOO, Jae-Chern

    IPC: G01N27/447

    CPC classification number: F15C3/06 ,  B01L3/502738 ,  B01L2200/10 ,  B01L2300/0806 ,  B01L2400/0633 ,  F16K99/0001 ,  F16K99/0013 ,  F16K99/0023 ,  F16K99/0028 ,  F16K99/0046 ,  F16K2099/0078 ,  G01N35/00069 ,  G01N2035/00247

    Abstract: A micro (thin film type) valve apparatus for controlling fluid flow and its rate using a microbead and a method for controlling the apparatus are provided. The microbead is moved by the magnetic forge generated by upper and lower electromagnets disposed on the top and bottom surface of the body or by the electric field generated by upper and lower electrode plates disposed on the top and bottom surface of the body, thereby interconnecting or blocking flow channels in the body. The micro valve apparatus and the method for controlling the same are suitable for thin film type diagnostic assay devices, such as lab-on-chips, protein chips, or DNA chips, for detecting small quantities of analytes in fluids, and more suitable for interconnecting or blocking channels formed in thin disk type apparatus including general CD-ROMs,DVDs, bioCDs, and bio DVDs.

    Abstract translation: 提供了一种用于控制流体流动的微（薄膜型）阀装置及其使用微珠的速率和控制该装置的方法。 微珠通过设置在身体的顶部和底部表面上的上部和下部电磁体产生的磁性锻造或由设置在身体的顶部和底部表面上的上部和下部电极板产生的电场而移动，从而互连或 阻止体内的流动通道。 微阀装置及其控制方法适用于薄膜型诊断测定装置，例如片上实验室，蛋白质芯片或DNA芯片，用于检测流体中的少量分析物，更适合互连 或阻塞通道形成在包括通用CD-ROM，DVD，bioCD和生物DVD的薄盘式设备中。

    MICROFLUIDIC CHIP
    10.
    发明申请
    MICROFLUIDIC CHIP 审中-公开
    微流控芯片

    公开(公告)号：WO2016059419A2

    公开(公告)日：2016-04-21

    申请号：PCT/GB2015/053068

    申请日：2015-10-15

    Applicant: RANDOX LABORATORIES LTD

    Inventor： JACKSON, Stuart ,  CROCKARD, Martin ,  HASWELL, Steve

    IPC: B01L3/00

    CPC classification number: B01L3/5027 ,  B01L3/5023 ,  B01L3/502738 ,  B01L2300/0887 ,  B01L2400/0644 ,  F16K99/0001 ,  F16K99/0013 ,  F16K2099/0084

    Abstract: According to the invention there is a microfluidic chip (1) that includes at least two layers (10) forming a stack of layers, each layer of which has at least one flow channel (14); a bore (16) extending through the layers and communicating with a plurality of flow channels; and a valve (20), which has a shaft (22) with a recess (222) in a side of the shaft for fluid to flow through. The shaft is rotatably mounted in the bore, and has a first position in which the recess is aligned with each of at least two flow channels of the plurality of flow channels thereby providing a flow path between said at least two flow channels, and a second position in which the recess is unaligned with at least one of said at least two flow channels the flow path between said at least two flow channels thereby being closed. This allows a fluid flow path between two flow channels to be open and closed by rotation of the shaft so that fluid in the microfluidic chip can be redirected to allow the chip to have greater capability and by using a minimal amount of space on the chip to do so.

    Abstract translation: 根据本发明，存在一个微流体芯片（1），其包括形成层叠层的至少两个层（10），每层具有至少一个流动通道（14）; 孔（16），其延伸穿过所述层并与多个流动通道连通; 以及阀（20），其具有在所述轴的侧面具有凹部（222）的轴（22），用于使流体流动。 轴可旋转地安装在孔中，并且具有第一位置，其中凹部与多个流动通道中的至少两个流动通道中的每一个对准，从而在所述至少两个流动通道之间提供流动路径，并且第二 所述凹部与所述至少两个流动通道中的至少一个不对齐的位置，所述至少两个流动通道之间的流动路径因此被封闭。 这允许两个流动通道之间的流体流动路径通过轴的旋转而打开和关闭，使得微流体芯片中的流体可以被重定向以允许芯片具有更大的能力，并且通过在芯片上使用最小量的空间 这样做。

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