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    SPATIAL TEMPERATURE GRADIENTS IN LIQUID CHROMATOGRAPHY
    1.
    发明申请
    SPATIAL TEMPERATURE GRADIENTS IN LIQUID CHROMATOGRAPHY 审中-公开
    液相色谱中的空间温度梯度

    公开(公告)号：WO2016138208A1

    公开(公告)日：2016-09-01

    申请号：PCT/US2016/019471

    申请日：2016-02-25

    申请人： WATERS TECHNOLOGIES CORPORATION

    发明人： FOGWILL, Michael, O. ,  MICHIENZI, Joseph, D. ,  GILAR, Martin ,  TARAFDER, Abhijit

    IPC分类号： G01N30/00 ,  G01N30/02 ,  G01N30/26 ,  G01N30/30

    CPC分类号： G01N30/30 ,  G01N30/34 ,  G01N2030/3015 ,  G01N2030/3076

    摘要： Methods for focusing analyte peaks in liquid chromatography using a spatial temperature gradient are provided. Also provided are methods for focusing analyte peaks and improving resolution using a trap column upstream of a separation column. Further, methods are provided in which the trap column placed upstream of the separation column is packed with a temperature- sensitive polymer/copolymer, and a spatial temperature gradient is applied along the trap column for obtaining improved retentivity by trap column stationary phase, and overall improved resolution of analyte peaks.

    摘要翻译： 提供了使用空间温度梯度在液相色谱中聚焦分析物峰的方法。 还提供了用于聚焦分析物峰的方法，并使用分离塔上游的捕获柱来提高分辨率。 此外，提供了设置在分离塔上游的捕集塔填充温度敏感性聚合物/共聚物的方法，并且沿着捕集塔施加空间温度梯度以通过陷阱柱固定相获得改进的保持性，并且总体上 提高分析物峰的分辨率。

    MANAGING FLUIDIC CONNECTIONS TO MICROFLUIDIC DEVICES
    2.
    发明申请
    MANAGING FLUIDIC CONNECTIONS TO MICROFLUIDIC DEVICES 审中-公开
    管理流体连接到微流体装置

    公开(公告)号：WO2013116285A1

    公开(公告)日：2013-08-08

    申请号：PCT/US2013/023771

    申请日：2013-01-30

    申请人： WATERS TECHNOLOGIES CORPORATION

    发明人： GERHARDT, Geoff, C. ,  FADGEN, Keith, Edward ,  MICHIENZI, Joseph, D. ,  BUNNER, Bernard

    IPC分类号： B01D15/08

    CPC分类号： G01N30/38 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/567 ,  B01L2200/0689 ,  B01L2400/0622 ,  B01L2400/0644 ,  F04D15/00 ,  F04D29/086 ,  F16K99/0013 ,  G01N30/20 ,  G01N2030/202

    摘要： A system (e.g., a chromatography system) includes a rotor, a microfluidic device, a rotor driver, a clamping mechanism, and control electronics. The rotor defines a plurality of first fluid-conveying features. The micro fluidic device defines one or more channels and a plurality of second fluid-conveying features, in fluid communication with the one or more channels. The rotor driver is coupled to the rotor and is configured to rotate the rotor, relative to the microfluidic device, between a first position and a second position such that, in each of the positions, at least one of the first fluid-conveying features cooperates with at least one of the one or more channels to provide for fluid communication therebetween. The clamping mechanism is operable to provide a sealing force to establish a fluid-tight seal between the rotor and the microfluidic device.

    摘要翻译： 系统（例如，色谱系统）包括转子，微流体装置，转子驱动器，夹紧机构和控制电子装置。 转子限定多个第一流体输送特征。 微流体装置限定与一个或多个通道流体连通的一个或多个通道和多个第二流体输送特征。 转子驱动器联接到转子并且构造成使转子相对于微流体装置在第一位置和第二位置之间旋转，使得在每个位置中，第一流体输送特征中的至少一个配合 具有一个或多个通道中的至少一个以提供其间的流体连通。 夹紧机构可操作以提供密封力，以在转子和微流体装置之间建立流体密封的密封。

    DUAL MODE SAMPLE MANAGER
    4.
    发明申请
    DUAL MODE SAMPLE MANAGER 审中-公开

    公开(公告)号：WO2020198115A1

    公开(公告)日：2020-10-01

    申请号：PCT/US2020/024166

    申请日：2020-03-23

    申请人： WATERS TECHNOLOGIES CORPORATION

    发明人： CORMIER, Sylvain, Gilles ,  MICHIENZI, Joseph, D.

    IPC分类号： B01D15/14 ,  G01N30/20 ,  G01N30/24

    摘要： Described is a dual mode sample manager for a liquid chromatography system. The dual mode sample manager includes a sample needle, a sample loop, a metering pump, a needle seat and first and second valves. Each valve is configurable in two valve states to enable two modes of operation. In one mode, sample acquired and stored in the sample needle is injected into a chromatography system flow and, in the other mode, sample acquired through the sample needle and stored in the sample loop is injected into the chromatography system flow. The automated switching of the sample manager between the two modes of operation avoids the need for maintaining two separate liquid chromatography systems or manual reconfiguration of a chromatography system for users desiring the capability of both modes of operation.

    METHOD AND APPARATUS FOR LINEARIZING AND MITIGATING DENSITY DIFFERENCES ACROSS MULTIPLE CHROMATOGRAPHIC SYSTEMS
    6.
    发明申请
    METHOD AND APPARATUS FOR LINEARIZING AND MITIGATING DENSITY DIFFERENCES ACROSS MULTIPLE CHROMATOGRAPHIC SYSTEMS 审中-公开
    用于在多色谱系统之间线性化和减少密度差异的方法和设备

    公开(公告)号：WO2018052952A1

    公开(公告)日：2018-03-22

    申请号：PCT/US2017/051293

    申请日：2017-09-13

    申请人： WATERS TECHNOLOGIES CORPORATION

    发明人： SHREVE, Joshua, A. ,  HILL, Jason, F. ,  MICHIENZI, Joseph, D. ,  TARAFDER, Abhijit ,  FOGWILL, Michael, O.

    IPC分类号： B01D15/08

    CPC分类号： B01D15/40 ,  B01D15/163 ,  B01D15/1871 ,  G01N30/32 ,  G01N30/6065 ,  G01N30/8658 ,  G01N30/8672

    摘要： Methods for transferring a carbon dioxide based separation procedure from a first chromatographic system to a second one involve identifying an average column pressure for the separation in the first system is identified, determining a measured average column pressure for the separation in the second system, and comparing the measured average column pressure with the identified average column pressures. To more closely match the identified average column pressure, the methods involve: (a) altering a cross-sectional area of a column packed with media in the second system; and/or (b) adding makeup fluid along the length of the column in the second system. Columns with the characteristics used in the methods and second chromatographic systems are disclosed.

    摘要翻译： 用于将基于二氧化碳的分离程序从第一色谱系统转移到第二色谱系统的方法涉及识别用于第一系统中的分离的平均柱压力，识别出测量的用于 在第二系统中分离，并将测得的平均柱压与所确定的平均柱压进行比较。 为了更接近地匹配所确定的平均柱压力，所述方法包括：（a）改变第二系统中填充有介质的柱的横截面积; 和/或（b）在第二系统中沿着柱的长度添加补充流体。 公开了具有方法和第二色谱系统中所用特征的色谱柱。