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    SYSTEMS AND METHODS OF REGULATING TEMPERATURE OF A SOLID-STATE SHEAR PULVERIZATION OR SOLID-STATE MELT EXTRUSION DEVICE
    1.
    发明申请
    SYSTEMS AND METHODS OF REGULATING TEMPERATURE OF A SOLID-STATE SHEAR PULVERIZATION OR SOLID-STATE MELT EXTRUSION DEVICE 审中-公开
    固态剪切或固态熔融挤出装置的温度调节系统和方法

    公开(公告)号：WO2015073366A1

    公开(公告)日：2015-05-21

    申请号：PCT/US2014/064811

    申请日：2014-11-10

    申请人： ZZYZX POLYMERS LLC

    发明人： BRUNNER, Philip ,  TAPSAK, Mark

    IPC分类号： B29C47/00

    CPC分类号： B29C47/6006 ,  B29B7/482 ,  B29B7/823 ,  B29C47/0825 ,  B29C47/0845 ,  B29C47/402 ,  B29C47/6087 ,  B29C47/842 ,  B29C47/845 ,  B29C47/92 ,  B29C2947/92704 ,  B29C2947/92876

    摘要： Systems and methods for controlling the temperature of a solid-state screw extruder may include providing an extrusion screw that incorporates one or more screw shaft channels. The shaft channels may be configured to conduct a flow of a heat conducting medium along a length of the shaft. The shaft channels may be incorporated into an exterior surface or within the body of the screw shaft. The extruder may include extrusion screw elements in mechanical communication with the shaft. Each of the elements may further include one or more element channels also configured to conduct a flow of the medium. The shaft channels and the element channels may be disposed to permit a flow of the medium therebetween. The temperature of the extrusion screws and/or screw elements may be controlled by circulating the medium from a source, through the shaft and element channels, and back to the source.

    摘要翻译： 用于控制固态螺杆挤出机的温度的系统和方法可以包括提供包括一个或多个螺杆轴通道的挤出螺杆。 轴通道可以被配置成沿着轴的长度传导导热介质的流动。 轴通道可以结合到螺钉轴的外表面或主体内。 挤出机可以包括与轴机械连通的挤压螺杆元件。 每个元件还可以包括一个或多个元件通道，其也被配置成进行介质的流动。 轴通道和元件通道可以被设置成允许介质之间的流动。 挤出螺钉和/或螺杆元件的温度可以通过使介质从源，通过轴和元件通道循环回到源来控制。

    FABRICATING DRUG DELIVERY SYSTEMS
    3.
    发明申请
    FABRICATING DRUG DELIVERY SYSTEMS 审中-公开
    制造药物输送系统

    公开(公告)号：WO2015054595A1

    公开(公告)日：2015-04-16

    申请号：PCT/US2014/060073

    申请日：2014-10-10

    申请人： ZZYZX POLYMERS LLC

    发明人： BRUNNER, Philip ,  TAPSAK, Mark

    IPC分类号： A61K9/14 ,  B29C47/38 ,  B29C47/78

    CPC分类号： A61K9/146 ,  A61L15/22 ,  A61L15/44 ,  A61L17/005 ,  A61L27/14 ,  A61L27/54 ,  A61L31/04 ,  A61L31/16 ,  B29C47/822 ,  B29C47/827

    摘要： Systems, methods, compositions, and devices related to the delivery of one or more biologically active agents to a body include the admixture of one or more biologically active agents with one or more biocompatible polymeric mixtures in a solid-state shear extrusion system. The extrusion systems may include one or more extrusion screws. One or more portions of the one or more extrusion screws, one or more extrusion system active elements, one or more barrel sections, and/or one or more extruder work zones may be temperature controlled to maintain a temperature of the biocompatible polymeric mixture in contact therewith at or below the liquefication temperature of the biocompatible polymeric materials. The resulting compositions from the extrusion systems may be fabricated into devices to deliver the one or more biologically active agents to a body.

    摘要翻译： 与一种或多种生物活性剂递送到身体有关的系统，方法，组合物和装置包括一种或多种生物活性剂与固态剪切挤出系统中的一种或多种生物相容性聚合物混合物的混合物。 挤出系统可以包括一个或多个挤出螺钉。 一个或多个挤出螺杆，一个或多个挤出系统活性元件，一个或多个筒部分和/或一个或多个挤出机工作区的一个或多个部分可以被温度控制以保持生物相容性聚合物混合物的温度接触 其中处于或低于生物相容性聚合物材料的液化温度。 来自挤出系统的所得组合物可以制造成将一种或多种生物活性剂递送到身体的装置。

    INCREASING THROUGHPUT OF SOLID-STATE EXTRUSION DEVICES
    4.
    发明申请
    INCREASING THROUGHPUT OF SOLID-STATE EXTRUSION DEVICES 审中-公开

    公开(公告)号：WO2015034889A3

    公开(公告)日：2015-03-12

    申请号：PCT/US2014/053845

    申请日：2014-09-03

    申请人： ZZYZX POLYMERS LLC

    发明人： BRUNNER, Philip ,  TAPSAK, Mark ,  JANSE, Michael

    IPC分类号： B02C23/28 ,  B29B7/00 ,  C08F6/00

    摘要： A method for improving the throughput of solid-state shear pulverization and solid-state melt-extrusion devices may include the addition of a heat absorbing material with a mixture of polymeric materials in an extruder. The extruder may include one or more extrusion screws. One or more portions of the one or more extrusion screws, one or more barrel sections, and/or one or more extruder work zones may be temperature controlled to maintain a temperature of the polymeric mixture in contact therewith at or below the liquefication temperature of the polymeric materials. The liquefication temperature may be a melting point of a semi-crystalline polymer or a glass transition temperature of an amorphous polymer.