-
公开(公告)号:WO2022263829A1
公开(公告)日:2022-12-22
申请号:PCT/GB2022/051520
申请日:2022-06-16
申请人: Z FACTOR LIMITED
发明人: RAMSDEN, Nigel , FOX, David John , HUNTINGTON, James Andrew , TOMLINSON, James Michael , HEAL, Jonathan Richard , SHERIDAN, Joseph Michael , EARL, Matthew William Mark
IPC分类号: C07D207/263 , C07D209/44 , C07D213/64 , A61P11/00 , C07D213/68 , C07D215/227 , C07D215/233 , C07D231/20 , C07D231/56 , C07D233/70 , C07D237/14 , C07D237/32 , C07D239/36 , C07D239/54 , C07D239/88 , C07D241/18 , C07D241/44 , C07D249/12 , C07D253/04 , C07D253/06 , C07D253/08 , C07D261/12 , C07D263/38 , C07D403/10 , C07D413/10 , A61K31/517 , A61K31/4412 , A61K31/513 , A61K31/5377
摘要: The invention relates to compounds or salts of Formula (I-a), Formula (I-b), Formula (I-c), Formula (I-d), Formula (II) and pharmaceutical compositions containing these compounds. The compounds may be inducers of α1-antitrypsin (A1AT), and may be used in the treatment of a disease or disorder such as α1-antitrypsin deficiency (A1AD or AATD).
-
公开(公告)号:WO2022263820A1
公开(公告)日:2022-12-22
申请号:PCT/GB2022/051506
申请日:2022-06-15
申请人: Z FACTOR LIMITED
发明人: RAMSDEN, Nigel , FOX, David John
IPC分类号: A61P1/16 , A61P11/00 , A61P35/00 , C07D241/04 , C07D265/30 , A61K31/495 , A61K31/5375
摘要: The invention relates to compounds of formula (I): wherein R1 and X are as defined in the application, and their medical uses, for example for use in the treatment of α1-antitrypsin deficiency (A1AD or AATD).
-
公开(公告)号:WO2022263817A1
公开(公告)日:2022-12-22
申请号:PCT/GB2022/051503
申请日:2022-06-15
申请人: Z FACTOR LIMITED
发明人: RAMSDEN, Nigel , FOX, David John
IPC分类号: C07D211/96 , A61P1/16 , A61P11/00 , A61P35/00 , A61K31/445
摘要: The invention relates to compounds of formula (I) wherein R1-R4, m and n are as described in the application, and their medical uses, for example for use in the treatment of α1-antitrypsin deficiency (A1AD or AATD).
-
公开(公告)号:WO2022263816A1
公开(公告)日:2022-12-22
申请号:PCT/GB2022/051502
申请日:2022-06-15
申请人: Z FACTOR LIMITED
IPC分类号: A61K31/445 , A61P11/00
摘要: The invention relates to pharmaceutical compositions comprising (S)-1-((2-(trifluoromethyl)phenyl)sulfonyl)piperidine-3-carboxylic acid and their medical use, for example for use in the treatment of α1-antitrypsin deficiency (AATD).
-
公开(公告)号:WO2021255429A1
公开(公告)日:2021-12-23
申请号:PCT/GB2021/051488
申请日:2021-06-15
申请人: Z FACTOR LIMITED
IPC分类号: C07D239/36 , A61K31/513 , A61P1/00 , A61P1/16 , A61P11/00 , A61P11/06 , A61P11/08
摘要: The invention includes a process for the synthesis of N,N-dimethyl-4-((6-oxopyrimidin-1(6H)- yl)methyl)benzamide and 4-((6-oxopyrimidin-1(6H)-yl)methyl)benzoic acid, a process for 5 synthesising crystalline forms of N,N-dimethyl-4-((6-oxopyrimidin-1(6H)- yl)methyl)benzamide, and crystalline forms of N,N-dimethyl-4-((6-oxopyrimidin-1(6H)- yl)methyl)benzamide.
-
6.
公开(公告)号:WO2021255436A1
公开(公告)日:2021-12-23
申请号:PCT/GB2021/051496
申请日:2021-06-15
申请人: Z FACTOR LIMITED
IPC分类号: C07D239/36 , A61K31/513 , A61P11/00 , A61P11/06 , A61P11/08 , A61P1/00 , A61P1/16 , A61P43/00
摘要: • A composition comprising 4-((6-oxopyrimidin-1(6H)-yl)methyl) benzoic acid, • 4-((6-oxopyrimidin-1(6H)-yl)methyl) benzoic acid for use as a medicament, • 4-((6-oxopyrimidin-1(6H)-yl)methyl) benzoic acid for use in a method of treatment of alpha 1 antitrypsin deficiency (A1AD or AATD) and • 4-((6-oxopyrimidin-1(6H)-y l)methyl) benzoic acid for use as an inducer of Z A1AT secretion in vitro, for example in an in vitro assay, as well as in vivo for the treatment of AATD
-
公开(公告)号:WO2022263819A1
公开(公告)日:2022-12-22
申请号:PCT/GB2022/051505
申请日:2022-06-15
申请人: Z FACTOR LIMITED
发明人: RAMSDEN, Nigel , FOX, David John
IPC分类号: A61P1/16 , A61P11/00 , A61P35/00 , C07D211/96 , A61K31/445
摘要: The invention relates to compounds of formula (I): (I) wherein R1 is as defined in the application, and their medical uses, for example for use in the treatment of α1-antitrypsin deficiency (A1AD or AATD).
-
公开(公告)号:WO2021116706A1
公开(公告)日:2021-06-17
申请号:PCT/GB2020/053191
申请日:2020-12-11
申请人: Z FACTOR LIMITED
发明人: RAMSDEN, Dr. Nigel , FOX, Dr. David John , HUNTINGTON, Prof. James Andrew , TOMLINSON, Dr. James Michael
IPC分类号: C07D239/36 , A61P11/00 , C07D239/91 , A61K31/513 , A61K31/517 , A61K31/5377
摘要: The invention relates to specified benzamide compounds of formula (1), and pharmaceutical compositions containing the compounds. The compounds may be inducers of α1-antitrypsin (A1AT), and may be used in the treatment of a disease or disorder such as α1-antitrypsin deficiency (A1AD or AATD).
-
公开(公告)号:WO2020120992A1
公开(公告)日:2020-06-18
申请号:PCT/GB2019/053552
申请日:2019-12-13
申请人: Z FACTOR LIMITED
IPC分类号: C07D239/36 , A61K31/513 , A61P1/16 , A61P11/06 , A61P11/08
摘要: The invention relates to oxopyrimidinyl-methyl-benzamide derivatives, for example in a pharmaceutically acceptable salt form or crystal form, pharmaceutical compositions comprising the derivatives, and their medical use, in particular for use in the treatment of α1-antitrypsin deficiency (A1AD or AATD).
-
公开(公告)号:WO2021116710A1
公开(公告)日:2021-06-17
申请号:PCT/GB2020/053196
申请日:2020-12-11
申请人: Z FACTOR LIMITED
IPC分类号: C07D413/10 , A61P11/00 , A61K31/513 , A61K31/517
摘要: The invention relates to specified oxazole compounds of formula (1), and pharmaceutical compositions containing the compounds. The compounds may be inducers of α1- antitrypsin (A1AT), and may be used in the treatment of a disease or disorder such as α1- antitrypsin deficiency (A1AD or AATD).
-
-
-
-
-
-
-
-
-