公开(公告)号：WO2013066376A1

公开(公告)日：2013-05-10

申请号：PCT/US2012/022192

申请日：2012-01-23

Applicant: TITAN SPINE, LLC ,  PATTERSON, Chad, J. ,  SCHNEIDER, Jennifer, M. ,  ULLRICH, Peter, F. ,  BERG, Mark

Inventor： PATTERSON, Chad, J. ,  SCHNEIDER, Jennifer, M. ,  ULLRICH, Peter, F. ,  BERG, Mark

IPC: A61F2/44 ,  A61B17/70 ,  A61F2/30

CPC classification number: A61F2/30767 ,  A61F2/4455 ,  A61F2/4465 ,  A61F2/4611 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30013 ,  A61F2002/30321 ,  A61F2002/30454 ,  A61F2002/30769 ,  A61F2002/30774 ,  A61F2002/30779 ,  A61F2002/30785 ,  A61F2002/30787 ,  A61F2002/30789 ,  A61F2002/30838 ,  A61F2002/3084 ,  A61F2002/30906 ,  A61F2002/3092 ,  A61F2002/30925 ,  A61F2002/30927 ,  A61F2002/3093 ,  A61F2002/3097 ,  A61F2002/30985 ,  A61F2002/4475 ,  A61F2002/4629 ,  A61F2310/00023 ,  A61F2310/00407 ,  Y10S977/81 ,  Y10S977/91

Abstract: An implantable device for treating disc degenerative disease and artliritis of the spine. The implant is sized for placement into an intravertebral disc space. The implant has a body with a predetermined, defined, repeating, three-dimensional pattern at least partially on at least one of its surfaces. The pattern is adapted to create a surface area of bone-contacting features that enhance in-growth and biological attachment to a biocompatible material. Also disclosed are process steps for making the implant.

Abstract translation: 用于治疗椎间盘退行性疾病和脊柱炎的植入式装置。 植入物的大小用于放置在椎间盘内。 植入物具有至少部分地在至少一个表面上具有预定的，限定的，重复的三维图案的主体。 该图案适于产生增强生物相容性材料的生长和生物附着的骨接触特征的表面积。 还公开了用于制造植入物的工艺步骤。

公开(公告)号：WO2012125290A1

公开(公告)日：2012-09-20

申请号：PCT/US2012/027059

申请日：2012-02-29

Applicant: AXIOMED SPINE CORPORATION

Inventor： ZIMMERS, Karl ,  DUKE, Keith ,  KURAS, James ,  BLICE, Rebecca ,  BRAGG, Iawny

IPC: A61F2/44

CPC classification number: A61F2/442 ,  A61F2/30744 ,  A61F2002/30126 ,  A61F2002/30133 ,  A61F2002/30158 ,  A61F2002/30487 ,  A61F2002/305 ,  A61F2002/30504 ,  A61F2002/30546 ,  A61F2002/30563 ,  A61F2002/30841 ,  A61F2002/30848 ,  A61F2002/30879 ,  A61F2002/30925 ,  A61F2002/30968 ,  A61F2002/4475 ,  A61F2310/00023 ,  A61F2310/00407

Abstract: An apparatus for replacing a damaged spinal disc in a spinal column includes a first retaining device having an outer surface engageable with a first vertebra of the spinal column and an inner surface. A second retaining device has an outer surface engageable with a second vertebra of the spinal column and an inner surface. A resilient core has a first surface and a second surface. The first surface engages the inner surface of the first retaining device. The second surface engages the inner surface of the second retaining device. The resilient core has a tapered radially outer surface extending from adjacent the first surface to adjacent the second surface. The first retaining device may have a flange extending toward the second retaining device. A concave surface may extend between thefirst surface and the radially outer surface.

Abstract translation: 用于替换脊柱中受损脊椎盘的装置包括具有可与脊柱的第一椎骨接合的外表面和内表面的第一保持装置。 第二保持装置具有可与脊柱的第二椎骨和内表面接合的外表面。 弹性芯具有第一表面和第二表面。 第一表面接合第一保持装置的内表面。 第二表面接合第二保持装置的内表面。 弹性芯具有从相邻的第一表面延伸到邻近第二表面的锥形径向外表面。 第一保持装置可以具有朝向第二保持装置延伸的凸缘。 凹面可以在第一表面和径向外表面之间延伸。

公开(公告)号：WO2011082403A3

公开(公告)日：2011-11-24

申请号：PCT/US2011020053

申请日：2011-01-03

Applicant: RHAUSLER INC ,  GEISLER FRED H ,  BASS DANIEL ,  JOHNSTON TERRY

Inventor： GEISLER FRED H ,  BASS DANIEL ,  JOHNSTON TERRY

IPC: A61F2/44 ,  A61B17/70 ,  A61B17/82 ,  A61B17/86 ,  A61L27/04 ,  A61L27/12 ,  A61L27/14 ,  A61L27/38

CPC classification number: A61F2/447 ,  A61F2/442 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30056 ,  A61F2002/3008 ,  A61F2002/30271 ,  A61F2002/30448 ,  A61F2002/30576 ,  A61F2002/30578 ,  A61F2002/30604 ,  A61F2002/30774 ,  A61F2002/30777 ,  A61F2002/30787 ,  A61F2002/30789 ,  A61F2002/30904 ,  A61F2002/30906 ,  A61F2002/30925 ,  A61F2002/30927 ,  A61F2002/4475 ,  A61F2310/00023 ,  A61F2310/00047 ,  A61F2310/00053 ,  A61F2310/00071 ,  A61F2310/00203 ,  A61F2310/00221 ,  A61F2310/00239 ,  A61F2310/00293 ,  A61F2310/00796

Abstract: An anterior cervical column support having a hollow frame having a top load bearing surface and a bottom load bearing surface may be inserted between a first spinal vertebra and a second spinal vertebra. The top load bearing surface and the bottom load bearing surface may each include an opening allowing access to the interior of the frame. A front surface may extend between the top load bearing surface and the bottom load bearing surface, and a rear surface may extend between the top load bearing surface and the bottom load bearing surface. Two side surfaces are attached between the front surface and the rear surface, each side surface having a solid side panel that is at least x-ray translucent. An anterior (front) plate is attached to the front surface of the support device, where the front plate includes clearance holes for receiving fasteners for holding the front plate in position. The top load bearing surface and the bottom load bearing surface may include a serrated or other high friction surface for applying frictional forces between the load bearing surfaces and adjacent vertebrae.

Abstract translation: 具有具有顶部承载表面和底部承载表面的中空框架的前部颈椎柱支架可以插入在第一脊椎椎骨和第二脊椎椎骨之间。 顶部承载表面和底部承载表面可各自包括允许进入框架内部的开口。 前表面可以在顶部承载表面和底部承载表面之间延伸，并且后表面可以在顶部承载表面和底部承载表面之间延伸。 两个侧表面连接在前表面和后表面之间，每个侧表面具有至少x-射线半透明的实心侧板。 前部（前）板附接到支撑装置的前表面，其中前板包括用于接收用于将前板保持在位的紧固件的间隙孔。 顶部承载表面和底部承载表面可包括用于在承载表面和相邻椎骨之间施加摩擦力的锯齿形或其他高摩擦表面。

公开(公告)号：WO2011082403A2

公开(公告)日：2011-07-07

申请号：PCT/US2011/020053

申请日：2011-01-03

Applicant: RHAUSLER, INC. ,  GEISLER, Fred, H. ,  BASS, Daniel ,  JOHNSTON, Terry

Inventor： GEISLER, Fred, H. ,  BASS, Daniel ,  JOHNSTON, Terry

IPC: A61F2/44 ,  A61B17/70 ,  A61B17/82 ,  A61B17/86 ,  A61L27/04 ,  A61L27/12 ,  A61L27/14 ,  A61L27/38

CPC classification number: A61F2/447 ,  A61F2/442 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30056 ,  A61F2002/3008 ,  A61F2002/30271 ,  A61F2002/30448 ,  A61F2002/30576 ,  A61F2002/30578 ,  A61F2002/30604 ,  A61F2002/30774 ,  A61F2002/30777 ,  A61F2002/30787 ,  A61F2002/30789 ,  A61F2002/30904 ,  A61F2002/30906 ,  A61F2002/30925 ,  A61F2002/30927 ,  A61F2002/4475 ,  A61F2310/00023 ,  A61F2310/00047 ,  A61F2310/00053 ,  A61F2310/00071 ,  A61F2310/00203 ,  A61F2310/00221 ,  A61F2310/00239 ,  A61F2310/00293 ,  A61F2310/00796

Abstract: An anterior cervical column support having a hollow frame having a top load bearing surface and a bottom load bearing surface may be inserted between a first spinal vertebra and a second spinal vertebra. The top load bearing surface and the bottom load bearing surface may each include an opening allowing access to the interior of the frame. A front surface may extend between the top load bearing surface and the bottom load bearing surface, and a rear surface may extend between the top load bearing surface and the bottom load bearing surface. Two side surfaces are attached between the front surface and the rear surface, each side surface having a solid side panel that is at least x-ray translucent. An anterior (front) plate is attached to the front surface of the support device, where the front plate includes clearance holes for receiving fasteners for holding the front plate in position. The top load bearing surface and the bottom load bearing surface may include a serrated or other high friction surface for applying frictional forces between the load bearing surfaces and adjacent vertebrae.

Abstract translation: 具有具有顶部承载表面和底部承载表面的中空框架的前颈部柱支撑件可以插入在第一脊椎椎骨和第二脊椎椎骨之间。 顶部承载表面和底部承载表面可以各自包括允许进入框架内部的开口。 前表面可以在顶部承载表面和底部承载表面之间延伸，并且后表面可以在顶部承载表面和底部承载表面之间延伸。 两个侧表面附接在前表面和后表面之间，每个侧表面具有至少x射线半透明的实心侧面板。 前（前）板附接到支撑装置的前表面，其中前板包括用于接收用于将前板保持在适当位置的紧固件的间隙孔。 顶部承载表面和底部承载表面可以包括用于在承载表面和相邻的椎骨之间施加摩擦力的锯齿或其它高摩擦表面。

公开(公告)号：WO2009007373A1

公开(公告)日：2009-01-15

申请号：PCT/EP2008/058860

申请日：2008-07-08

Applicant: ASTRA TECH AB ,  PETERSSON, Ingela ,  FREDRIKSSON, Anette

Inventor： PETERSSON, Ingela ,  FREDRIKSSON, Anette

IPC: A61F2/30 ,  A61C8/00 ,  A61K6/04 ,  A61L27/04 ,  A61L27/06 ,  A61L27/30 ,  A61L27/50 ,  C23F1/26

CPC classification number: A61F2/30767 ,  A61C8/0012 ,  A61C2008/0046 ,  A61F2/3094 ,  A61F2002/30719 ,  A61F2002/30906 ,  A61F2002/30925 ,  A61F2002/30929 ,  A61F2250/0092 ,  A61F2310/00023 ,  A61F2310/00598 ,  A61F2310/00616 ,  A61L27/306 ,  A61L2400/12 ,  B82Y5/00 ,  B82Y30/00 ,  C23C8/00 ,  C23C8/10 ,  C23C22/46 ,  C23C26/00 ,  C23G1/106

Abstract: The invention relates to a method for modification of a biocompatible component comprising the steps of a) providing a biocompatible component at least partly covered by metallic oxide; and b) treating at least a part of said component, which part is covered by said metallic oxide, with an aqueous composition comprising oxalic acid; whereby a modified metallic oxide is obtained. The invention also relates to a biocompatible component comprising a substrate having a surface comprising a) a microstructure comprising pits separated by plateus and/or ridges; and b) a primary nanostructure being superimposed on said microstructure, said primary nanostructure comprising depressions arranged in a wave-like formation.

Abstract translation: 本发明涉及生物相容性成分的修饰方法，包括以下步骤：a）提供至少部分被金属氧化物覆盖的生物相容性成分; 和b）用包含草酸的含水组合物处理所述部分被所述金属氧化物覆盖的部分的至少一部分; 得到改性金属氧化物。 本发明还涉及一种生物相容性成分，其包含具有表面的基底，该基底包括a）微结构，其包括由平片和/或脊分离的凹坑; 和b）叠加在所述微观结构上的初级纳米结构，所述初级纳米结构包括以波状形式布置的凹陷。

公开(公告)号：WO2006121795B1

公开(公告)日：2008-03-06

申请号：PCT/US2006017252

申请日：2006-05-04

Applicant: TITAN SPINE LLC ,  BAGGA CHARANPREET S ,  ULLRICH PETER F JR ,  DORAN MICHAEL E DORAN

Inventor： BAGGA CHARANPREET S ,  ULLRICH PETER F JR ,  DORAN MICHAEL E DORAN

IPC: A61F2/44

CPC classification number: A61F2/4465 ,  A61F2/30965 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30785 ,  A61F2002/30836 ,  A61F2002/30906 ,  A61F2002/30925 ,  A61F2002/4475 ,  A61F2310/00017 ,  A61F2310/00023

Abstract: This present invention relates to interbody spinal implants and methods of using such implants. Certain embodiments of the present invention are particularly suitable for placement using an anterior surgical approach. Certain embodiments of the present invention include a body having a top surface, a bottom surface, opposing lateral sides, and opposing anterior and posterior portions. Interbody spinal implants, as now taught, further include roughened surface topography on at least a portion of its top surface and/or bottom surface. Preferred embodiments of the interbody spinal implant are substantially hollow and have a generally oval-shaped transverse cross-sectional area. Preferred embodiments of further include at least one aperture that extends the entire height of the implant body. This vertical aperture also defines a transverse rim having greater posterior thickness than anterior thickness. Certain embodiments also preferably include at least one aperture that extends the entire transverse length of the implant body.

Abstract translation: 本发明涉及体内脊柱植入物和使用这种植入物的方法。 本发明的某些实施例特别适用于使用前路手术方法的放置。 本发明的某些实施例包括具有顶表面，底表面，相对的侧边以及相对的前部和后部的主体。 如现在教导的椎间植入物植入物还包括在其顶表面和/或底表面的至少一部分上的粗糙表面形貌。 体内脊柱植入物的优选实施方案基本上是中空的并且具有大致椭圆形的横截面积。 进一步包括延伸植入体整个高度的至少一个孔的优选实施例。 该垂直孔还限定了具有比前部厚度更大的后部厚度的横向边缘。 某些实施例还优选地包括延伸植入体整个横向长度的至少一个孔。

公开(公告)号：WO2007114996A1

公开(公告)日：2007-10-11

申请号：PCT/US2007/063936

申请日：2007-03-14

Applicant: WARSAW ORTHOPEDIC, INC. ,  TRIEU, Hai, H. ,  MOLZ, Fred, J., IV

Inventor： TRIEU, Hai, H. ,  MOLZ, Fred, J., IV

IPC: A61F2/44

CPC classification number: A61F2/442 ,  A61F2/30942 ,  A61F2/4425 ,  A61F2002/30014 ,  A61F2002/30016 ,  A61F2002/30026 ,  A61F2002/30042 ,  A61F2002/30092 ,  A61F2002/30563 ,  A61F2002/30578 ,  A61F2002/30649 ,  A61F2002/30663 ,  A61F2002/30841 ,  A61F2002/30884 ,  A61F2002/30899 ,  A61F2002/30906 ,  A61F2002/30925 ,  A61F2002/443 ,  A61F2002/444 ,  A61F2210/0014 ,  A61F2250/0018 ,  A61F2250/0019 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00041 ,  A61F2310/00089 ,  A61F2310/00119 ,  A61F2310/00131 ,  A61F2310/00407 ,  A61F2310/00796 ,  A61F2310/00976

Abstract: A method of treating a patient includes determining a patient characteristic associated with the patient, determining a property value based at least in part on the patient characteristic, and determining a crosslinking parameter based at least in part on the property value.

Abstract translation: 治疗患者的方法包括确定与患者相关联的患者特征，至少部分地基于患者特征来确定特性值，以及至少部分地基于所述特性值来确定交联参数。

公开(公告)号：WO2007090035A1

公开(公告)日：2007-08-09

申请号：PCT/US2007/061068

申请日：2007-01-25

Applicant: WARSAW ORTHOPEDIC, INC. ,  HEINZ, Eric, S. ,  TRIEU, Hai, H.

Inventor： HEINZ, Eric, S. ,  TRIEU, Hai, H.

IPC: A61F2/44

CPC classification number: A61F2/4425 ,  A61F2/441 ,  A61F2/4611 ,  A61F2002/30224 ,  A61F2002/30235 ,  A61F2002/30383 ,  A61F2002/30448 ,  A61F2002/30462 ,  A61F2002/30467 ,  A61F2002/30649 ,  A61F2002/3065 ,  A61F2002/30654 ,  A61F2002/30663 ,  A61F2002/30686 ,  A61F2002/30769 ,  A61F2002/30785 ,  A61F2002/30808 ,  A61F2002/30836 ,  A61F2002/30841 ,  A61F2002/30845 ,  A61F2002/30884 ,  A61F2002/30925 ,  A61F2002/3097 ,  A61F2002/443 ,  A61F2220/0025 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2220/0083 ,  A61F2230/0069 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00179 ,  A61F2310/00365 ,  A61F2310/0097 ,  A61F2310/00976

Abstract: An intervertebral prosthetic disc (400) is disclosed and can be installed within an intervertebral space between a first vertebra and a second vertebra. The intervertebral prosthetic disc can include a first component (500) that can have a first compliant structure (520) that can be configure to engage the first vertebra. Further, the first compliant structure can at least partially conform to a shape of the first vertebra. The intervertebral prosthetic disc can also include a second component (600) that can be configured to engage the second vertebra.

Abstract translation: 公开了椎间体假体椎间盘（400），并且可以将其安装在第一椎骨和第二椎骨之间的椎间空间内。 椎间假体椎间盘可以包括第一部件（500），其可以具有可配置成接合第一椎骨的第一顺应结构（520）。 此外，第一柔顺结构可以至少部分地符合第一椎骨的形状。 椎间假体椎间盘还可以包括可被构造成接合第二椎骨的第二部件（600）。

公开(公告)号：WO2007087550A1

公开(公告)日：2007-08-02

申请号：PCT/US2007/060942

申请日：2007-01-24

Applicant: WARSAW ORTHOPEDIC, INC ,  VITTUR, Shannon, M. ,  ROULEAU, Jeffrey, P. ,  HEINZ, Eric, S.

Inventor： VITTUR, Shannon, M. ,  ROULEAU, Jeffrey, P. ,  HEINZ, Eric, S.

IPC: A61F2/44

CPC classification number: A61F2/4425 ,  A61F2/4611 ,  A61F2002/2817 ,  A61F2002/30224 ,  A61F2002/30654 ,  A61F2002/30662 ,  A61F2002/30663 ,  A61F2002/30769 ,  A61F2002/30808 ,  A61F2002/30836 ,  A61F2002/30884 ,  A61F2002/30925 ,  A61F2002/443 ,  A61F2230/0069 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00179 ,  A61F2310/00407 ,  A61F2310/00796

Abstract: An intervertebral prosthetic disc (400) is disclosed and can be installed within an intervertebral space between an inferior vertebra and a superior vertebra. The intervertebral prosthetic disc includes a superior component (500) that can be configured to engage the superior vertebra and an inferior component (600) that can be configured to engage the inferior vertebra. A nucleus can be disposed between the superior component and the inferior component. The nucleus (700) can be configured to allow relative motion between the superior component and the inferior component. Further, the intervertebral prosthetic disc can include at least one nucleus containment feature (530,532,630) that can be configured to prevent the nucleus from migrating with respect to the superior component and the inferior component without interfering with the relative motion between the superior component and the inferior component in any direction.

Abstract translation: 公开了一种椎间盘假体盘（400），并且可以将其安装在下椎骨和上椎骨之间的椎间空间内。 椎间盘假体盘包括可构造成接合上椎骨的上部构件（500）和可配置成接合下椎骨的下部构件（600）。 核可以设置在上部部件和下部部件之间。 核（700）可以被配置为允许上部部件和下部部件之间的相对运动。 此外，椎间假体椎间盘可以包括至少一个细胞核容纳特征（530,532,630），其可以被配置为防止细胞核相对于上部组分和下部组分迁移而不会干扰上部组分和下部之间的相对运动 组件在任何方向。

公开(公告)号：WO2007062283A2

公开(公告)日：2007-05-31

申请号：PCT/US2006060590

申请日：2006-11-02

Applicant: WARSAW ORTHOPEDIC INC ,  ALLARD RANDALL N ,  BRYAN VINCENT ,  KUNZLER ALEX ,  FINAZZO ANTHONY V ,  GIL CARLOS E ,  CONTA ROBERT L

Inventor： ALLARD RANDALL N ,  BRYAN VINCENT ,  KUNZLER ALEX ,  FINAZZO ANTHONY V ,  GIL CARLOS E ,  CONTA ROBERT L

IPC: A61F2/44

CPC classification number: A61F2/4425 ,  A61F2002/2817 ,  A61F2002/30133 ,  A61F2002/30332 ,  A61F2002/30364 ,  A61F2002/30461 ,  A61F2002/30462 ,  A61F2002/30474 ,  A61F2002/30495 ,  A61F2002/30571 ,  A61F2002/30662 ,  A61F2002/30663 ,  A61F2002/30665 ,  A61F2002/30685 ,  A61F2002/30738 ,  A61F2002/30884 ,  A61F2002/30904 ,  A61F2002/30906 ,  A61F2002/30925 ,  A61F2002/443 ,  A61F2002/448 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/0075 ,  A61F2230/0015 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00161 ,  A61F2310/00167 ,  A61F2310/00203 ,  A61F2310/00239 ,  A61F2310/00796

Abstract: A method for implanting an articulating intervertebral disc prosthesis into an intervertebral disc space comprises surgically accessing the intervertebral disc space through an opening on a first lateral side of the intervertebral disc space and inserting a first half of the articulating intervertebral disc prosthesis through the opening and into the intervertebral disc space. The method further comprises inserting a second half of the articulating intervertebral disc prosthesis through the opening on the first lateral side of the intervertebral disc space and positioning the first half of the articulating intervertebral disc prosthesis on a second lateral side of the intervertebral disc space. The method also comprises positioning the second half of the articulating intervertebral disc prosthesis on the first lateral side of the intervertebral disc space.

Abstract translation: 将关节​​式椎间盘假体植入椎间盘空间中的方法包括通过椎间盘空间的第一侧面上的开口手术地进入椎间盘空间，并将关节式椎间盘假体的前半部穿过开口插入 椎间盘间隙。 该方法还包括通过椎间盘空间的第一侧面上的开口插入关节式椎间盘假体的第二半部分，并将关节式椎间盘假体的前半部分定位在椎间盘空间的第二侧面上。 该方法还包括将关节式椎间盘假体的第二半部定位在椎间盘间隙的第一侧面上。