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    EPICUTANEOUS TEST PLASTER
    3.
    发明申请
    EPICUTANEOUS TEST PLASTER 审中-公开
    表皮测试补丁

    公开(公告)号：WO1998025521A1

    公开(公告)日：1998-06-18

    申请号：PCT/EP1997006532

    申请日：1997-11-21

    Applicant: LOHMANN GMBH & CO. KG ,  ANHÄUSER, Dieter ,  ECKER, Jürgen ,  SCHENTEK, Heike

    Inventor： LOHMANN GMBH & CO. KG

    IPC: A61B10/00

    CPC classification number: A61B10/0035 ,  A61F13/023 ,  A61F2013/00434 ,  A61F2013/00829

    Abstract: The invention concerns an epicutaneous test plaster (1) with at least one active substance absorption device (4; 9, 10) disposed on a highly resilient carrier film (6) made of polymer material. The carrier film (6) is impervious to liquid water and permeable to water vapour and, on the face remote from the skin, is detachably connected to a support film (2) and, on the face facing the skin, is provided with a layer (7) of bonding substance which in turn, before the plaster (1) is applied, is covered by an at least two-part detachable protective layer (8). The invention is characterized in that the protective layer (8) is connected at two opposite edges to the support film (2) in hinge-like manner (11).

    Abstract translation: 的表皮试验石膏（1）上的载体膜的至少一个（6），其设置活性物质吸收装置（4; 9,10），具有致密液态水透过水蒸汽，高弹性的背衬膜（6）的聚合物材料的，贴在皮肤上 表面从支撑膜（2）的面向远离可释放地连接并在与压敏粘合剂层面对皮肤表面的一侧（7）设置，反过来，（1）之前覆盖有至少两部分可分离的保护层（8）的补丁的应用，其特征在于 在于在两个相对边缘上的保护层（8）铰接（11）与支持片材（2）连接。

    HAND WASHING ASSESSMENT METHOD
    4.
    发明申请
    HAND WASHING ASSESSMENT METHOD 审中-公开
    手洗评估方法

    公开(公告)号：WO2009087047A1

    公开(公告)日：2009-07-16

    申请号：PCT/EP2008/068013

    申请日：2008-12-19

    Applicant: UNILEVER PLC ,  UNILEVER N.V. ,  HINDUSTAN UNILEVER LIMITED ,  BELLAMY, Kathryn ,  SANDEL, Melanie, Jane

    Inventor： BELLAMY, Kathryn ,  SANDEL, Melanie, Jane

    IPC: A61L15/28 ,  A61L15/56 ,  A61F13/10 ,  C08L1/00

    CPC classification number: A61L2/28 ,  A61F2013/00297 ,  A61F2013/00434 ,  A61F2013/00948 ,  A61F2013/15048

    Abstract: The invention provides a method for assessing the effectiveness of skin washing in a subject, comprising the steps of : (a) applying a patch to a target area of the skin of a subject before washing of the target area, followed by (b) assessing the appearance of the patch after washing of the target area; in which the patch comprises a substrate for attachment to the skin; and in which the patch is designed to undergo a visually perceptible change which is dependent on the effectiveness of the method used by the subject to wash the target area.

    Abstract translation: 本发明提供了一种用于评估受试者皮肤洗涤效果的方法，包括以下步骤：（a）在洗涤目标区域之前将斑块施用于受试者皮肤的目标区域，随后（b）评估 洗涤目标区域后补丁的外观; 其中所述贴片包括用于附接到皮肤的基底; 并且其中贴片被设计成经历视觉上可察觉的变化，其取决于受试者用于洗涤目标区域的方法的有效性。

    STICKING-PLASTER
    5.
    发明申请
    STICKING-PLASTER 审中-公开
    狗皮膏药

    公开(公告)号：WO1991001705A1

    公开(公告)日：1991-02-21

    申请号：PCT/EP1989000931

    申请日：1989-08-07

    Applicant: MINNINGER, Konrad ,  OBERHAGEMANN, Rainer ,  TANG, David

    IPC: A61F13/02

    CPC classification number: A61B10/0035 ,  A61F13/0226 ,  A61F13/0259 ,  A61F2013/00119 ,  A61F2013/00429 ,  A61F2013/00434 ,  A61F2013/008 ,  A61F2013/00982

    Abstract: A sticking-plaster consists of a highly flexible basic material (10) the front surface of which is provided with an adhesive coating (12). The adhesive coating (12) is covered by a detachable protective cover (14). The rear surface of the basic material (10) of the sticking-plaster adheres to a detachable rear part (16) which is stiffer than the basic material. The sticking plaster is therefore easier to manipulate after the protective cover (14) is detached. This in turn improves the flexibility of the basic material (10). The sticking-plaster is therefore less affected by movements and adheres more firmly.

    HAND WASHING ASSESSMENT METHOD
    6.
    发明申请
    HAND WASHING ASSESSMENT METHOD 审中-公开
    手洗评估方法

    公开(公告)号：WO2009087046A1

    公开(公告)日：2009-07-16

    申请号：PCT/EP2008/068012

    申请日：2008-12-19

    Applicant: UNILEVER PLC ,  UNILEVER N.V. ,  HINDUSTAN UNILEVER LIMITED ,  HOPTROFF, Michael, John ,  THOMPSON, Katherine, Mary

    Inventor： HOPTROFF, Michael, John ,  THOMPSON, Katherine, Mary

    IPC: A61L15/22 ,  A61L15/56 ,  A61F13/10

    CPC classification number: A61Q19/10 ,  A61F2013/00297 ,  A61F2013/00434 ,  A61F2013/00948 ,  A61F2013/15048 ,  A61K2800/42 ,  A61K2800/5424 ,  A61L15/56

    Abstract: The invention provides a method for assessing the effectiveness of skin washing in a subject, comprising the steps of : (a) applying a patch on or over a target area of the skin of a subject before washing of the target area, followed by (b) assessing the appearance of the patch after washing of the target area; in which the patch comprises a pH sensitive indicator which is designed to undergo a visually perceptible change in colour when contacted with an alkaline composition, such as soap or other anionic surfactant, during washing of the target area, and in which assessment of the appearance of the patch after washing provides an indication to the assessor whether an alkaline composition, such as soap or other anionic surfactant, has or has not been used to wash the target area.

    Abstract translation: 本发明提供了一种用于评估受试者皮肤洗涤效果的方法，包括以下步骤：（a）在洗涤目标区域之前在受试者的皮肤的目标区域上或之上施用贴片，随后是（b ）评估洗涤目标区域后贴片的外观; 其中贴剂包含pH敏感指示剂，其被设计成在洗涤目标区域期间与碱性组合物如皂或其它阴离子表面活性剂接触时经历视觉上可察觉的颜色变化，并且其中评估外观 洗涤后的贴剂为评估者提供了碱性组合物（例如肥皂或其它阴离子表面活性剂）是否已被用于洗涤目标区域的指示。

    METHOD AND APPARATUS FOR DETERMINATION OF CHEMICAL SPECIES IN PERSPIRATION
    8.
    发明申请
    METHOD AND APPARATUS FOR DETERMINATION OF CHEMICAL SPECIES IN PERSPIRATION 审中-公开
    用于确定化妆品中化学物质的方法和装置

    公开(公告)号：WO1994014062A1

    公开(公告)日：1994-06-23

    申请号：PCT/US1993012143

    申请日：1993-12-13

    Applicant: SUDOR PARTNERS

    Inventor： SUDOR PARTNERS ,  SCHOENDORFER, Donald, W.

    IPC: G01N33/483

    CPC classification number: G01N33/54386 ,  A61B5/411 ,  A61B5/415 ,  A61B5/418 ,  A61B5/4266 ,  A61B10/0035 ,  A61B10/0051 ,  A61B10/0064 ,  A61B2010/0009 ,  A61F7/032 ,  A61F2013/00195 ,  A61F2013/00434 ,  A61F2013/00608 ,  A61F2013/00642 ,  A61F2013/00646 ,  A61F2013/00655 ,  A61F2013/00731 ,  A61F2013/00863 ,  A61F2013/00902 ,  A61F2013/8411 ,  A61F2013/842 ,  A61F2013/8473 ,  A61F2013/8491 ,  B01L3/505

    Abstract: A dermal patch (90) to be worn on the skin for increasing the concentration of an analyte expressed through the skin in perspiration to a conveniently measurable level. Included are patches and methods of using such patches to determine the quantity of an analyte in a given volume of perspiration, to determine a subject's sensitivity to an allergen, to allow an analyte to be detected with conventional detection systems, and to dissolve the structural components of a patch to facilitate analyte detection. In addition, by delivering electricity to the patch, adding a buffer to the concentration zone (14) of the patch, or otherwise controlling the pH of fluids entering the patch, analytes in perspiration can be concentrated on the patch without the occurrence of significant back-diffusion of the analytes. Also, by generating heat on the surface of the skin of a subject wearing the patch, perspiration can be collected over a much shorter period of time, preferably over the course of about an hour.

    Abstract translation: 穿戴在皮肤上的皮肤贴片（90），用于增加汗水中通过皮肤表达的分析物的浓度，以方便测量的水平。 包括使用这种贴片的贴片和方法来确定在给定体积的汗水中的分析物的量，以确定受试者对变应原的敏感性，以允许用常规检测系统检测分析物，并溶解结构组分 的补丁以促进分析物检测。 另外，通过向贴片输送电力，向贴片的浓缩区域（14）添加缓冲液，或以其他方式控制进入贴片的流体的pH值，汗液中的分析物可以集中在贴片上而不会发生明显的背部 扩散分析物。 此外，通过在穿着贴片的受试者的皮肤的表面上产生热量，可以在更短的时间段内优选地在约1小时的时间段内收集出汗。

    METHOD AND APPARATUS FOR DETERMINATION OF CHEMICAL SPECIES IN BODY FLUID
    9.
    发明申请
    METHOD AND APPARATUS FOR DETERMINATION OF CHEMICAL SPECIES IN BODY FLUID 审中-公开
    用于确定体液中化学物质的方法和装置

    公开(公告)号：WO1992003731A1

    公开(公告)日：1992-03-05

    申请号：PCT/US1991005252

    申请日：1991-07-24

    Applicant: SUDOR PARTNERS

    Inventor： SUDOR PARTNERS ,  SCHOENDORFER, Donald, W. ,  MILLER, William, R.

    IPC: G01N33/543

    CPC classification number: G01N33/54386 ,  A61B5/14521 ,  A61B5/14532 ,  A61B5/411 ,  A61B5/415 ,  A61B5/418 ,  A61B5/4266 ,  A61B5/6833 ,  A61B10/0035 ,  A61B10/0051 ,  A61B10/0064 ,  A61B2010/0009 ,  A61F2013/00195 ,  A61F2013/00434 ,  A61F2013/00608 ,  A61F2013/00642 ,  A61F2013/00646 ,  A61F2013/00655 ,  A61F2013/00731 ,  A61F2013/00863 ,  A61F2013/00902 ,  A61F2013/8411 ,  A61F2013/842 ,  A61F2013/8473 ,  A61F2013/8491 ,  A61M35/006 ,  B01L3/505

    Abstract: Disclosed is a method and apparatus for determining the presence of an analyte in a subject mammal's perspiration. The apparatus is a patch (52, 62, 70) that includes a water permeable support layer (20), and in certain embodiments includes a feature to detect tampering with the patch to produce false negative results. In such embodiments, this feature can comprise a reagent in a reference zone (61) that is a specific binding partner for a reference substituent in the perspiration, a soluble marker within the patch, a test region for detecting the presence of an adulterant capable of producing false negative results, an identifying marker (67) unique to each patch, or a plurality of stress razors (66). In another embodiment, the patch includes an attenuation layer (92) for attenuating the amount of light reaching the support layer for detection of photosensitive analytes. In still another embodiment, the patch (70) includes pinhole perforations (73) within a band (72) near the perimeter of the patch (70).

    Abstract translation: 公开了一种用于确定受试哺乳动物出汗中分析物的存在的方法和装置。 该装置是包括透水性支撑层（20）的贴片（52,62,70），并且在某些实施例中包括检测篡改贴片以产生假阴性结果的特征。 在这样的实施方案中，该特征可以包括参考区（61）中的试剂，其是汗液中的参考取代基的特异性结合配偶体，贴剂内的可溶性标记物，用于检测掺入物的存在的测试区域， 产生假阴性结果，每个贴片独有的识别标记（67）或多个应力剃刀（66）。 在另一个实施例中，贴片包括衰减层（92），用于衰减到达支持层的光量，用于检测光敏分析物。 在另一个实施例中，贴片（70）包括靠近贴片（70）的周边的带（72）内的针孔穿孔（73）。

    APPLICATION UNIT FOR EPICUTANEOUS TESTING OR TREATMENT
    10.
    发明申请
    APPLICATION UNIT FOR EPICUTANEOUS TESTING OR TREATMENT 审中-公开
    环境试验或治疗应用单位

    公开(公告)号：WO1981000199A1

    公开(公告)日：1981-02-05

    申请号：PCT/SE1980000191

    申请日：1980-07-18

    Applicant: ALANI S ,  SELLMAN M

    IPC: A61B10/00

    CPC classification number: A61B10/0035 ,  A61F2013/00434

    Abstract: Application unit to be used for epicutaneous testing to clarify the etiology and diagnosis of allergic contact eczema and for the administration of therapeutically active substances for topical treatment of skin diseases, and comprising a carrier (10) which consists of a number of application devices (11) each one of said devices is supplied with an application surface (13) for one substance (14). The application device is composed of a nonabsorbent material. The said application surface is essentially located at the same level with the carrier's adhesive surface (12) and is surrounded by an annular groove. The application units are covered by a covering layer (17) which is provided with domes (18) located above each application device and encompass the substances hermatically.

    Abstract translation: 用于表皮测试的应用单元，以阐明过敏性接触性湿疹的病因和诊断以及用于局部治疗皮肤疾病的治疗活性物质的给药，并且包括载体（10），其由许多施用装置（11 ）为每个所述装置提供用于一种物质（14）的应用表面（13）。 施用装置由非吸收性材料构成。 所述施加表面基本上与载体的粘合剂表面（12）位于相同的高度，并被环形槽包围。 应用单元由覆盖层（17）覆盖，覆盖层（17）设置有位于每个施加装置上方的圆顶（18），并且包含物质。

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