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    IMMUNOGENIC COMPOSITIONS AND VACCINES FOR PREVENTING OR TREATING FILARIAL DISEASE
    1.
    发明申请
    IMMUNOGENIC COMPOSITIONS AND VACCINES FOR PREVENTING OR TREATING FILARIAL DISEASE 审中-公开
    用于预防或治疗疾病的免疫组织化学物质和疫苗

    公开(公告)号：WO2016149460A1

    公开(公告)日：2016-09-22

    申请号：PCT/US2016/022787

    申请日：2016-03-17

    Applicant: THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

    Inventor： MITRE, Edward, E. ,  MORRIS, Christopher ,  BENNURU, Sasisekhar ,  NUTMAN, Thomas

    IPC: A61P33/10 ,  A61K38/16 ,  A61K39/00 ,  C07K14/00

    CPC classification number: A61K39/0003 ,  A61K38/1767 ,  A61K39/39 ,  A61K2039/55566 ,  A61P33/10 ,  C07K14/4354

    Abstract: The present disclosure is directed to an immunogenic composition and method for preventing or treating a filarial disease including: at least one or at least two isolated polypeptides or immunogenic fragments thereof, and optionally a pharmaceutically acceptable carrier, wherein each polypeptide is expressed on a luminal surface of an intestine of a filarial worm, wherein each polypeptide is expressed at a level at least two-fold higher in the intestine in comparison to the level of expression of each polypeptide in a reproductive tract or a body wall of the filarial worm, wherein each isolated polypeptide has at least one transmembrane domain, and wherein each polypeptide is a non-mitochondrial polypeptide.

    Abstract translation: 本公开涉及用于预防或治疗丝状病的免疫原性组合物和方法，包括：至少一种或至少两种分离的多肽或其免疫原性片段，以及任选的药学上可接受的载体，其中每个多肽在腔表面上表达 的丝状蠕虫的肠道，其中每条多肽在肠道中的生殖道或体壁中每种多肽的表达水平与肠道蠕虫的体细胞表达水平相比至少高两倍，其中每个多肽 分离的多肽具有至少一个跨膜结构域，并且其中每个多肽是非线粒体多肽。

    LYME DISEASE VACCINE
    6.
    发明申请
    LYME DISEASE VACCINE 审中-公开
    LYME DISEATE VACCINE

    公开(公告)号：WO2014065679A1

    公开(公告)日：2014-05-01

    申请号：PCT/PL2013000133

    申请日：2013-10-21

    Applicant: INST CHEMIII BIOORG PAN

    Inventor： URBANOWICZ ANNA ,  FIGLEROWICZ MAREK ,  LEWANDOWSKI DOMINIK

    IPC: A61K39/00 ,  A61K39/02

    CPC classification number: C07K14/43527 ,  A61K38/00 ,  A61K39/00 ,  A61K39/0003 ,  A61K39/0225 ,  A61K39/39 ,  A61K45/06 ,  C07K14/445 ,  C12N15/64 ,  C12N15/86

    Abstract: The present invention relates to a Lyme disease vaccine, a genetic construct, recombinant protein, method for genetic construct design, method for vaccine delivery, method for recombinant proteins delivery, use of recombinant proteins in the production of Lyme disease vaccine. In particular, the method concerns the use of TROSPA and TROSPA- Salpl 5 recombinant proteins derived from castor bean tick {Ixodes riccinus) as a component of Lyme disease vaccine for animals. The antibodies present in blood of an immunized vertebrate directed against the TROSPA proteins considerably reduce the chance of infecting new ticks by blocking or hindering the interaction of TROSPA protein with OspA protein of Borrelia burgdorferi sensu lato. The interaction is crucial in the process of the spirochete entering a tick. The antibodies directed against the TROSPA- Salpl5 protein protect vertebrates from infection on the stage of Borellia diffusion by destroying their protective coating formed at the surface as a result of the interaction between the Salpl5 tick protein and OspC spirochete protein. The vaccine based on TROSPA tick proteins and TROSPA-Salpl5 proteins may be used independently or together with the OspA recombinant proteins and OspC protein of Borrelia burgdorferi sensu lato.

    Abstract translation: 本发明涉及莱姆病疫苗，遗传构建体，重组蛋白，遗传构建体设计方法，疫苗递送方法，重组蛋白递送方法，重组蛋白在莱姆病疫苗生产中的应用。 特别地，该方法涉及使用衍生自蓖麻虱（蓖麻毒素）的TROSPA和TROSPA-Salpl 5重组蛋白作为动物的莱姆病疫苗的组分。 存在于针对TROSPA蛋白的免疫脊椎动物的血液中的抗体通过阻断或阻碍TROSPA蛋白与博氏疏螺旋体的OspA蛋白的相互作用大大降低了感染新蜱的机会。 在螺旋体进入蜱的过程中，相互作用至关重要。 针对TROSPA-Salpl5蛋白的抗体通过破坏由于Salpl5蜱蛋白和OspC螺旋体蛋白之间的相互作用而在表面形成的保护性涂层来保护脊椎动物免受Borellia扩散阶段的感染。 基于TROSPA蜱蛋白和TROSPA-Salpl5蛋白的疫苗可以独立使用或与OspA重组蛋白和布氏疏螺旋体的OspC蛋白一起使用。

    PROTEÍNA RECOMBINANTE DE HAEMONCHUS CONTORTUS Y SU APLICACIÓN PARA LA PRODUCCIÓN DE UNA VACUNA FRENTE A LA HEMONCOSIS
    7.
    发明申请
    PROTEÍNA RECOMBINANTE DE HAEMONCHUS CONTORTUS Y SU APLICACIÓN PARA LA PRODUCCIÓN DE UNA VACUNA FRENTE A LA HEMONCOSIS 审中-公开
    重组蛋白质联合作物及其用于生产灭活疫苗的疫苗

    公开(公告)号：WO2014037592A1

    公开(公告)日：2014-03-13

    申请号：PCT/ES2013/000197

    申请日：2013-09-04

    Applicant: UNIVERSIDAD COMPLUTENSE DE MADRID

    Inventor： ALUNDA RODRÍGUEZ, José María ,  CUQUERELLA AYENSA, Montserrat ,  MOHAMED FAWZI, Elshaima

    IPC: C12N15/12 ,  A61K39/00 ,  C07K14/00 ,  A61P33/00

    CPC classification number: C07K14/4354 ,  A61K39/0003 ,  A61K2039/552 ,  A61K2039/55583 ,  A61K2039/55594

    Abstract: Se ha procedido a la obtención de una proteína recombinante (rHc23) de H. contortus tras comprobar que la proteína nativa Hc23, de 23kDa de peso molecular, originaria del extracto soluble de adultos del nematodo hematófago H. contortus ha mostrado capacidad inmunoprotectora en el ganado ovino joven de 5 meses de edad frente a la trichostrongilidosis más importante (hemoncosis) desde un punto de vista económico y patológico. Se ha caracterizado la proteína Hc23, obteniéndose las secuencias aminoacídicas y genómicas de la misma, permitiendo, por técnicas de biología molecular, ADN recombinante, la producción de una proteína estable, la rHc23. Su utilización en composiciones inmunogénicas que incluyen como adyuvante la combinación de Propionibacteríum acnés inactivado + lipopolisacáridos de E. coli ha mostrado un elevado grado de protección en los animales (>85% de protección).

    Abstract translation: 在确定了源自成体血液线虫线虫的可溶性提取物的分子量为23kDa的天然蛋白质Hc23在5个月的幼羊中表现出免疫保护能力后，产生幽门螺杆菌的重组蛋白（rHc23） 从经济和病理学的角度来看，对于最重要的trichostrongylidosis（haemonchosis）。 表征蛋白质Hc23，获得相同的基因组和氨基酸序列，其使用分子生物学技术重组DNA可用于产生稳定的蛋白质rHc23。 其在免疫原性组合物中的应用包括作为佐剂，灭活的大肠杆菌丙酸杆菌+脂多糖的组合已经在动物中保护了高度保护（保护率> 85％）。

    VACCINE
    8.
    发明申请
    VACCINE 审中-公开
    疫苗

    公开(公告)号：WO2013014408A8

    公开(公告)日：2014-02-13

    申请号：PCT/GB2012000608

    申请日：2012-07-23

    Applicant: MOREDUN RES INST ,  HUNTLEY JOHN FREDERICK ,  NISBET ALASDAIR JUSTICE

    Inventor： HUNTLEY JOHN FREDERICK ,  NISBET ALASDAIR JUSTICE

    IPC: A61K39/00

    CPC classification number: A61K39/0003

    Abstract: The present invention relates to antigens capable of raising host immune responses to parasites. In particular, the invention provides, vaccines for use in protecting against and/or reducing instances of parasite infection in avian hosts.

    Abstract translation: 本发明涉及能够增加寄生虫宿主免疫应答的抗原。 特别地，本发明提供了用于在禽类宿主中防止和/或减少寄生虫感染的疫苗的疫苗。

    VACCINATION OF ANIMALS TO ELICIT A PROTECTIVE IMMUNE RESPONSE AGAINST TICK INFESTATIONS AND TICK-BORNE PATHOGEN TRANSMISSION
    9.
    发明申请
    VACCINATION OF ANIMALS TO ELICIT A PROTECTIVE IMMUNE RESPONSE AGAINST TICK INFESTATIONS AND TICK-BORNE PATHOGEN TRANSMISSION 审中-公开
    动物疫苗攻击针对蜱虫感染和叮咬病原传播的保护性免疫应答

    公开(公告)号：WO2013177142A1

    公开(公告)日：2013-11-28

    申请号：PCT/US2013/041990

    申请日：2013-05-21

    Applicant: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF AGRICULTURE

    Inventor： GUERRERO Jr., Felicito ,  PEREZ DE LEON, Adalberto A.

    IPC: C12N15/63 ,  C12N15/70 ,  C12N15/12 ,  A61K31/7088 ,  A61P31/00

    CPC classification number: C07K14/43563 ,  A61K39/0003 ,  A61K2039/53 ,  A61K2039/552 ,  A61K2039/55566 ,  C07K14/43527

    Abstract: Two antigenic and immunogenic proteins of the cattle tick, Rhipicephalus microplus, and the genes encoding these proteins, are effective for eliciting a protective immune response that controls and prevents infestations of bovines and other livestock by the tick. The proteins isolated from the cattle tick include an aquaporin protein and a TC5777 gut membrane protein. Each of the proteins elicit an immunoprotective response in livestock to the cattle tick, and can be formulated and administered as vaccines. Alternatively, the isolated DNA sequences which encode these proteins can be incorporated into nucleic acid constructs which could be utilized as DNA vaccines. The nucleic acid constructs can also be used for the transformation of cells and the production of recombinant proteins. Induction of the protective immune response controls and prevents infestations of the treated animals with the tick, thereby protecting them against tick-borne pathogen transmission.

    Abstract translation: 牛蜱的两种抗原和免疫原性蛋白，Rhipicephalus microplus和编码这些蛋白质的基因对于引发保护性免疫应答是有效的，其通过蜱控制和防止牛和其他家畜的侵染。 从牛蜱分离的蛋白质包括水通道蛋白和TC5777肠膜蛋白。 每种蛋白质在牲畜中引起对牛蜱的免疫保护反应，并且可以作为疫苗进行配制和施用。 或者，编码这些蛋白质的分离的DNA序列可以并入可用作DNA疫苗的核酸构建体中。 核酸构建体也可用于细胞的转化和重组蛋白的产生。 诱导保护性免疫应答控制并防止经过处理的动物与蜱的侵染，从而保护它们免受蜱传播的病原体传播。

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